ISAP/EPASG 2025 Annual meeting, 10 April, Vienna, Austria

Oral sessions:

10th April 11.50‐12.05 Assessing the Therapeutic Potential of an Apramycin‐Gallium Combination for Treating Acinetobacter baumannii Lung  Infections; Anissa Benkhaled

10th April 14.05‐14.20 Dual AmpC and AmpD mutations in Pseudomonas aeruginosa: Unraveling the Mechanisms of Resistance to Ceftazidime and Avibactam; Albane Rozenholc

ESCMID Global, 11-15 April, Vienna, Austria

Oral sessions:

Vincent Aranzana-CLiment – 11/04/2025  – Educational Session: Looking into the crystal ball: exploring the fabulous world of PK-PD simulations

Posters:

Adrien Baillod –  P2957 – 12/04/2025– Manogepix and amphotericin B combination is synergistic against Candida glabrata as evidenced by a new pharmacodynamic-modelling approach

Anissa Benkhaled – P2400 – 13/04/2025 – Assessing the therapeutic potential of an apramycin-gallium combination for treating Acinetobacter baumannii lung infections

Julie Charles – P0717 – 13/04/2025 – Assessment of in vitro efficacy of three-antitbiotics combinations against Mycobacterium abscessus

Farras Daffa Imtiyaz – P2320 – 13/04/2025 – Enhancing colistin efficacy against multidrug-resistant Klebsiella pneumoniae using farnesol-loaded lipid nanoparticles

Albane Rozenholc – P1604 – 14/04/2025 – Dual AmpC and AmpD mutations in Pseudomonas aeruginosa: unraveling the mechanisms of resistance to ceftazidime and avibactam

34th ECCMID, 27-30 April, Barcelona, Spain

Oral sessions:

Alexia Chauzy – 28/04/2024  – Physiologically-based modelling in the study of antibiotic distribution in the CNS

Noémie Prébonnaud – 28/04/2024 – ePoster BES1408 – Impact of in vitro use of artificial cerebrospinal fluid compared to Mueller-Hinton broth on the efficacy of linezolid against Staphylococcus aureus in a hollow-fiber model

Farras Daffa Imtiyaz – 29/04/2024 – Presentation title : Adjuvant-loaded lipid nanoparticles to increase the susceptibility of Acinetobacter baumannii to colistin

Posters:

Alexia Chauzy – Poster area – P2518 – In vitro evaluation of the inoculum effect of various β-lactamases-producing Klebsiella pneumoniae isolates on ceftazidime-avibactam

Vincent Aranzana-Climent – Poster area – P2490 – Spotting method as a high throughput alternative to the conventional spread plating method for bacterial time-kill experiments

Vincent Aranzana-Climent – Poster area – P2492 – Development and validation of a PBPK model of gepotidacin in rats to predict exposure in human prostate

Maxime Vallée – Poster area – P2410 – Tissue distribution of ceftazidime-avibactam in kidney tissue in healthy rats and pigs using a microdialysis technique.

Adrien Baillod – Poster area – P2964 – Synergistic interaction between antifungal agents against Candida guilliermondii using pharmacondynamics-modelling approach

33^rd ECCMID, 15-18 April, Copenhagen, Danemark

Oral sessions:

Mathilde Lacroix – 15/04/2023 – 14:45 in Hall I – Transcriptomic data to support in vitro semi-mechanistic PK/PD modelling of polymyxin B against Acinetobacter baumannii

Noémie Prébonnaud – 15/04/2023 – 16:15 in Hall N – Predicting antibacterial efficacy of linezolid on Staphylococcus aureus in cerebral infections using in vitro hollow fiber model and pharmacokinetic/pharmacodynamic modelling

Alexia Chauzy – 16/04/2023 – 16:15 in Hall O – PKpopLCR study: pharmacokinetic and pharmacodynamic of linezolid in neurointensive care patients with external ventricular drainage

Luc Deroche – 17/04/2023 – 08:30 in Hall N – Development of cefiderocol resistance during treatment in Klebsiella pneumoniae due to the association of fhuA, cirA and fiu mutations

Claire Dahyot–Fizelier – 17/04/2023 – 13:30 in Hall J – Ceftriaxone to prevent early ventilator-acquired pneumonia in comatose brain-injured patients: a multicenter, randomized, double-blind, placebo-controlled trial

Kévin Brunet – 18/04/2023 – 08:30 in Hall O – Enhancement of amphotericin B activity against Cryptococcus neoformans using lipid nanoparticles

Posters:

Zahyra Kaouah, Julien Buyck, Sandrine Marchand, Christophe Burucoa, Maxime Pichon, Julie Cremniter, Nicolas Gregoire – 15/04/2023 – 12:00 in Poster Area – P0430 – In vitro efficacy of antibiotics used in clinical practice on clinical isolates of Helicobacter pylori

Zahyra Kaouah, Julien Buyck, Sandrine Marchand, Christophe Burucoa, Maxime Pichon, Julie Cremniter, Nicolas Gregoire – 15/04/2023 – 12:00 in Poster Area – P0429 – In vitro bactericidal activity of amoxicillin combined to clarithromycin or levofloxacin on clinical strains of Helicobacter pylori

Matthieu Boisson, Jeremy Guenezan, Christophe Burucoa, Gaël Rambault, Lila Couteau, Olivier Mimoz, Maxime Pichon – 15/04/2023 – 12:00 in Poster Area – P0488 – Impact of skin antisepsis on the prevalence of antibiotic–antiseptic cross–resistance genes in Staphylococcaceae.

Victor Luzzaraga, Maxime Pichon, Julie Cremniter, Sandrine Marchand, Julien Buyck, Christophe Burucoa – 15/04/2023 – 12:00 in Poster Area – P2198 – Validation by site-directed mutagenesis of mutations described as associated with clarithromycin resistance in Helicobacter pylori

Jean-Philippe Martellosio, Thais Villers, Nabil Gastli, Lauranne Broutin, Julie Cremniter, Anthony Michaud, Chloé Plouzeau, France Roblot, Christophe Burucoa, Maxime Pichon – 16/04/2023 – 12:00 in Poster Area – P1082 – Hypervirulent Klebsiella pneumoniae: prevalence, clinical presentation and antibiotic resistance in a French tertiary care hospital.

Mathilde Lacroix, Jérémy Moreau, Claudia Zampaloni, Caterina Bissantz, Hamasseh Shirvani, Sandrine Marchand, William Couet, Alexia Chauzy – 17/04/2023 – 12:00 in Poster Area – P0521 – PK/PD modelling of the CAMHB nutrients concentrations effect on polymyxin B antimicrobial activity against Acinetobacter baumannii

32^nd ECCMID, 23-26 April, Lisbon, Portugal

Poster –P1337: Comparison between pharmacokinetic-pharmacodynamic modelling results of ceftaroline against methicillin-resistant Staphylococcus aureus after time kill and hollow-fibre experiments – Alexia Chauzy

Poster – P1334 : In vivo pharmacokinetic-pharmacodynamic modelling of Acinetobacter baumannii inoculum effect on polymyxin B in a murine thigh infection model- Alexia Chauzy

Poster – P1343 : In vitro PK/PD modelling of polymyxin B against resistant strain of A. baumannii in presence of mucin – Mathilde Lacroix

Poster – 03559: Semi-mechanistic PKPD modelling of combined ceftazidime/avibactam and colistin against a multidrug-resistant strain of Klebsiella pneumoniae – Romain Aubry

Poster – 03484: Systematic interaction screening of ceftazidime/avibactam and colistin against eighteen carbapenem-producing Escherichia coli and Klebsiella pneumoniae strains – Romain Aubry

Poster – 03560: PEG-15-hydroxystearate non-ionic surfactant enhances amphotericin B activity against Mucorales in vitro – Kevin Brunet

Invited speaker – W0415 – The role of in vivo models – William Couet

RICAI, 13-14 December, Paris, France

Communication orale – Le PEG 15 hydroxystearate augmente l’activité in vitro de l’amphotéricine B sur les Mucorales – Kévin Brunet

Communication orale – Characterisation of in vivo acquired ceftolozane-tazobactam resistance in Pseudomonas aeruginosa – Luc Deroche

Présentation invité – COVID-19, pathogènes bactériens et microbiote– Maxime  Pichon

Présentation invité – Oxazolidinones : – PK/PD – quand faut-il doser ? – Sandrine Marchand

Présentation invité – Méthodes d’études des effets combinés des antimicrobiens– Alexia Chauzy

Journées d’animation scientifiques de la FéRi, 16-17 October, Tours, France

16e Congrès National de la SFM, 22-24 September, Nantes, France

Communication orale courte – Caractérisation par NGS de la diversification intra- et inter-hôte de Helicobacter pylori – Maxime Pichon

Poster – La présence de l’antigène K1 est associé à un profil d’antibiorésistance différent chez Escherichia coli – Maxime Pichon

Poster – Impact d’une pré-exposition aux antiseptiques sur l’émergence de l’antibiorésistance – Maxime Pichon

ECCMID 2021, 9-12  July 2021 – Online

E-poster – In vivo pk/pd analysis of the impact of the seize of the inoculum of Acinetobacter baumannii on polymyxin B – Grace Akrong

E-poster – In vitro PK/PD analysis of the impact of the size of the inoculum of Acinetobacter baumannii on polymyxin B – Grace Akrong

E-poster – HF-App, a R-Shiny web application to streamline single and dual drug hollow fiber experimental setup – Vincent Aranzana-Climent

E-poster – Pharmacokinetic/Pharmacodynamic modeling of gepotidacin against Escherichia coli and Naisseria gonorrhoeae in an in vitro hollow fiber infection model – Sandrine Marchand

E-poster – Population pharmacokinetic/pharmacodynamic study of ceftaroline after multiple doses administration in critical care patients with early-onset pneumonia and normal or augmented renal clearance – Nicolas Gregoire

E-poster –  Molecular characterisation of in vivo acquisition of resistances to ceftolozane tazobactam and ceftazidime avibactam in a patient treated for a Pseudomonas aeruginosa infection – Luc Deroche

World Microbe Forum (ASM), 20-24 June 2021, Online

E-poster – In Vitro PK/PD Analysis of the Impact of the Size of the Inoculum of Acinetobacter baumannii on Polymyxin B –  Grace Akrong

E-poster – In Vivo PK/PD Analysis of the Impact of the Size of the Inoculum of Acinetobacter baumannii on Polymyxin B –  Grace Akrong

JNI 21es Journées Nationales d’Infectiologie, 9-11 September 2020 – Poitiers -France

ECCMID 2020 – 18-21 April 2020 – Paris – France

21ème Colloque français des jeunes chercheurs VLM, 14 February 2020 – Paris – France

RICAI 2019 – 17-18 December 2019 – Paris – France

Oral Presentation – CO 041 – Rôle de MCR-1 dans la résistance adaptative aux polymyxines – Julien Buyck

Oral Presentation – CO 097 – Impact de la corticothérapie sur l’interaction macrophages alvéolaires et mucorales – Francois Arrivé

Poster Presentation -P-025 – In vitro study of antibiotic combinations efficacy on multiresistant Achromobacter xylosoxidans strains – Grace Akrong

Poster Presentation -P-116 – Modèle in vitro de biofilm pulmonaire à Pseudomonas aeruginosa – Rana Awad

Poster Presentation -P-210 – In vitro evaluation of novel bi- or tri-antibiotic combinations against clinical isolates of Mycobacterium abscessus – Shachi mehta

Poster Presentation -P-327 – Semi-mechanistic PK-PD modelling of combined polymyxin B and minocycline against a polymyxin-resistant strain of Acinetobacter baumannii – Vincent Aranzana-Climent

Poster Presentation -P-328 – A minimal physiologically-based pharmacokinetic model to investigate CNS distribution of metronidazole in ICU patients – Alexia Chauzy

Microbes SFM 2019 – 30 September to 02 October 2019 – Paris – France

Oral Presentation – Genetic characterization of LPS-modifying genes involved in polymyxin resistance in E. coli and K. pneumoniae carrying MCR-1 – Hariyanto IH

Poster Presentation – In vitro study of antibiotic combinations efficacy on multiresistant Achromobacter xylosoxidans strains – Grace Akrong

Poster Presentation – Shachi Mehta

Poster Presentation – Shachi Mehta

Poster Presentation – Vincent Aranzana – Climent

5^th International inhaled Therapies for tuberculosis and other infectious Diseases Conference – 25-27 August 2019 – Gröningen – Netherland

Oral Presentation– Biopharmaceutical Classification of Antibiotics for Pulmonary Delivery – Sandrine Marchand

Oral Presentation– A PK/PD type modelling approach to support time-kill data interpretation of cefoxitin for the treatment of Mycobacterium abscessus – Julien Buyck

Mycobacteria 2019 – 26-28 June 2019 – Angers – France

Oral Presentation– A PK/PD type modelling approach to support time-kill data interpretation of cefoxitin for the treatment of Mycobacterium abscessus – Julien Buyck

7^th NanoFar School – 24-26 June 2019 – Angers

Oral Presentation– Inhaled nanoparticles and microparticles to treat pulmonary biofilms– Frédéric Tewes

PAGE 2019 – 11-14 June 2019 – Stocholm – Sweden

Poster Presentation– Semi-mechanistic pharmacodynamics modeling of aztreonam-avibactam combination to understand its antimicrobial activity against multidrug-resistant Gram(-) bacteria – Alexia Chauzy, Bruna Torres, Julien Buyck, Christophe Adier, Sandrine Marchand, William Couet, Nicolas Grégoire.

Poster Presentation – Use of a semi-mechanistic PK-PD model to quantify the combination effect of polymyxin B and minocycline against polymyxin-resistant Acinetobacter baumannii – Vincent Aranzana-Climent, Julien Buyck, Lena Friberg, Younes Smani, Jeronimo Pachon-Diaz, Emma Marquizeau, William Couet, Nicolas Grégoire

Congrès SFP – SFMM – SFMPM – 22-24 May 2019 – Tours

ECCMID 2019 – 13-16 April 2019 – Amsterdam

Paper Poster – In vitro evaluation of novel bi- or tri-antibiotic combinations against clinical isolates of Mycobacterium abscessus – Shachi Metha, Hariyanto Ih, Blandine Rammaert, William Couet, Sandrine Marchand, Julien Buyck

Paper Poster – Sequential time-kill experiments to characterise adaptive resistance to polymyxins in Gram-negative bacteria carrying mcr-1– Hariyanto Ih, Nicolas Grégoire, William Couet, Julien Buyck

Paper Poster – Farnesol and geraniol loaded nanocapsules enhance the susceptibility of mcr-1 Escherichia coli to colistin – Frédéric Tewes, Chantal Valcourt, Julien Buyck, William Couet

ePoster Oral Session – A PK/PD type modelling approach to support time-kill data interpretation of cefoxitin for the treatment of Mycobacterium abscessus – Shachi Metha, Vincent Aranzana-Climent, Nicolas Grégoire, Sandrine Marchand, Julien Buyck, William Couet

Paper Poster – Use of a semi-mechanistic PK-PD model to quantify the combination effect of polymyxin B and minocycline against polymyxin-resistant Acinetobacter baumannii – Vincent Aranzana-Climent, Julien Buyck, Lena Friberg, Younes Smani, Jeronimo Pachon-Diaz, Emma Marquizeau, William Couet, Nicolas Grégoire

Paper Poster – In vitro activity of polymyxin B alone and in combination against colistin-resistant Acinetobacter baumannii – Vincent Aranzana-Climent, Alexia Chauzy, Nicolas Grégoire, Sandrine Marchand, William Couet, Julien Buyck

ISAP 2019 – 12 April 2019 – Rotterdam

Oral presentation – « PK/PD » type of modelling approach to support time-kill data interpretation of cefoxitin for the treatment of Mycobacterium abscessus – MEHTA Shachi

Oral presentation – Use of a semi-mechanistic PK-PD model to quantify the combination effect of polymyxin B and minocycline against polymyxin-resistant Acinetobacter baumannii – ARANZANA-CLIMENT Vincent

RICAI 2018 – 17-18 December 2018 – Paris – France

Paper poster – Cinétiques d’adaptation in vitro aux antibiotiques de Pseudomonas aeruginosa – Etienne Meriglier, Nicolas Grégoire, France Roblot, Sandrine Marchand, William Couet, Julien Buyck

Paper poster – Etude in vitro de la réversibilité de la résistance chez Pseudomonas aeruginosa – Etienne Meriglier, Nicolas Grégoire, France Roblot, Sandrine Marchand, William Couet, Julien Buyck

Joint 5^th Workshop on Pulmonary Drug Delivery and 1^st SimInhal Summer School – 25-27 September 2018 – Dublin – Ireland

BioBarriers 2018 – 27-29 August 2018 – Saarbrücken

Paper poster – Adjuvant effect of farnesol encapsulated within nanocapsules on colistin efficacy against MCR-1 E.coli – Valcourt c., Tewes F., Buyck J., Couet W.

Oral Presentation – Animal Model of Chronic Lung Infection to P. aeruginosa : Are Agar and Alginate beads interchangeable? – Frederic Tewes

ECCMID 2018 – 21-24 April 2018 – Madrid

Paper poster P2204 – Pulmonary pharmacokinetics of amikacin and cefoxitin after nebulization in rats S. Mehta* (Poitiers, France), I. Lamarche, C. Adier, J. Buyck, N. Gregoire, S. Marchand, W. Couet

Paper poster P2223 – Cerebrospinal fluid pharmacokinetics of ceftaroline in neurosurgical patients with externa lventricular drain P. Chavanet* (Dijon, France), A. Chauzy, N. Defrance, A. Nadji, J. Combes, W. Couet, L. Piroth

Paper poster P2230 – Microdialysis study combined with population pharmacokinetic analysis and Monte Carlo simulations for optimization of cefoxitin dosing regimen used for prophylaxis in major abdominal surgery B. Gaelzer Silva Torres* (Poitiers, France), M. Boisson, S. Yani, J. Laroche, W. Couet, O. Mimoz,
N. Gregoire, S. Marchand

Paper poster P2232 – Pharmacokinetics of colistin administered at 9MIU once daily in intensive care unit patients with preserved renal function. S. Magreault* (Poitiers, France), D. Bassoulis, N. Gregoire, A. Skiada, S. Marchand, W. Couet, G. Daikos

Paper poster P2421 – Semi-mechanistic pharmacokinetics/pharmacodynamics modelling of aztreonam-avibactam combination against multidrug-resistant Gram-negative organisms A. Chauzy* (Poitiers, France), B. Gaelzer Silva Torres, J. Buyck, E. Marquizeau, P. Gobin, B. Dejonge, S. Marchand, W. Couet, N. Gregoire

ECCMID 2017 – 22-25 April 2017 – Vienna

Paper poster P1214 – Microdialysis study distribution of aztreonam and avibactam in skeletal muscle and intraperitoneal fluid of rats with and without experimental peritonitis – A. Chauzy* (Poitiers, France), N. Gregoire, I. Lamarche, P. Gobin, W. Couet, S. Marchand

Invited speaker – Clinical Relevance of Protein Binding for drug Dosing – Sandrine Marchand

10^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology – 4 – 7 April 2016 – Glasgow – UK