Poster & Presentations

ECCMID 2020 – 18-21 April 2020 – Paris – France


Mini Oral flash SessionSequential time-kill experiments to characterize lypopolysaccharide-modifying genes involved in polymyxin resistance in Escherichia coli and Klebsiella pneumoniae carrying mcr-1 – Hariyanto IH

Poster Presentation – Sequential time-kill curve to distinguish polymyxin-induced resistance and hetero-resistance in Acinetobacter baumannii – Hariyanto IH

Mini-oral ePoster SessionComparison of patients’ brain microdialysate and cerebrospinal fluid concentrations versus time profiles of cefotaxime and metronidazole as representative antibiotic substrates or not of efflux transport systems – Alexia Chauzy

 

21ème Colloque français des jeunes chercheurs VLM, 14 February 2020 – Paris – France


Poster Presentation – In vitro model of Pseudomonas aeruginosa pulmonary biofilm to evaluate the efficacy of cationic antibioticsRana Awad

RICAI 2019 – 17-18 December 2019 – Paris – France


Oral Presentation – CO 041 – Rôle de MCR-1 dans la résistance adaptative aux polymyxines – Julien Buyck

Oral Presentation – CO 097 – Impact de la corticothérapie sur l’interaction macrophages alvéolaires et mucorales – Francois Arrivé

Poster Presentation -P-025 – In vitro study of antibiotic combinations efficacy on multiresistant Achromobacter xylosoxidans strains – Grace Akrong

Poster Presentation -P-116 – Modèle in vitro de biofilm pulmonaire à Pseudomonas aeruginosa – Rana Awad

Poster Presentation -P-210 – In vitro evaluation of novel bi- or tri-antibiotic combinations against clinical isolates of Mycobacterium abscessus – Shachi mehta

Poster Presentation -P-327 – Semi-mechanistic PK-PD modelling of combined polymyxin B and minocycline against a polymyxin-resistant strain of Acinetobacter baumannii – Vincent Aranzana-Climent

Poster Presentation -P-328 – A minimal physiologically-based pharmacokinetic model to investigate CNS distribution of metronidazole in ICU patients – Alexia Chauzy

 

Microbes SFM 2019 – 30 September to 02 October 2019 – Paris – France


Oral PresentationGenetic characterization of LPS-modifying genes involved in polymyxin resistance in E. coli and K. pneumoniae carrying MCR-1 – Hariyanto IH

Poster Presentation In vitro study of antibiotic combinations efficacy on multiresistant Achromobacter xylosoxidans strains – Grace Akrong

Poster Presentation – Shachi Mehta

Poster Presentation – Shachi Mehta

Poster Presentation – Vincent Aranzana – Climent

 

5th International inhaled Therapies for tuberculosis and other infectious Diseases Conference – 25-27 August 2019 – Gröningen – Netherland


Oral Presentation– Biopharmaceutical Classification of Antibiotics for Pulmonary Delivery – Sandrine Marchand

Oral PresentationA PK/PD type modelling approach to support time-kill data interpretation of cefoxitin for the treatment of Mycobacterium abscessus – Julien Buyck

 

 

Mycobacteria 2019 – 26-28 June 2019 – Angers – France


Oral PresentationA PK/PD type modelling approach to support time-kill data interpretation of cefoxitin for the treatment of Mycobacterium abscessus – Julien Buyck

 

 

7th NanoFar School – 24-26 June 2019 – Angers


Oral PresentationInhaled nanoparticles and microparticles to treat pulmonary biofilms– Frédéric Tewes

 

 

PAGE 2019 – 11-14 June 2019 – Stocholm – Sweden


Poster PresentationSemi-mechanistic pharmacodynamics modeling of aztreonam-avibactam combination to understand its antimicrobial activity against multidrug-resistant Gram(-) bacteria – Alexia Chauzy, Bruna Torres, Julien Buyck, Christophe Adier, Sandrine Marchand, William Couet, Nicolas Grégoire.

Poster PresentationUse of a semi-mechanistic PK-PD model to quantify the combination effect of polymyxin B and minocycline against polymyxin-resistant Acinetobacter baumannii – Vincent Aranzana-Climent, Julien Buyck, Lena Friberg, Younes Smani, Jeronimo Pachon-Diaz, Emma Marquizeau, William Couet, Nicolas Grégoire

 

Congrès SFP – SFMM – SFMPM – 22-24 May 2019 – Tours


Poster and Oral Presentation – La décolonisation par l’amphotéricine B liposomale prévient la survenue des mucormycoses pulmonaires à Lichtheimia corymbifera – Kévin Brunet, Thomas Brunet, Grégory Jouvion, Estelle Cateau, Sandrine Marchand, Blandine Rammaert

 

ECCMID 2019 – 13-16 April 2019 – Amsterdam


Paper PosterIn vitro evaluation of novel bi- or tri-antibiotic combinations against clinical isolates of Mycobacterium abscessus – Shachi Metha, Hariyanto Ih, Blandine Rammaert, William Couet, Sandrine Marchand, Julien Buyck

Paper PosterSequential time-kill experiments to characterise adaptive resistance to polymyxins in Gram-negative bacteria carrying mcr-1– Hariyanto Ih, Nicolas Grégoire, William Couet, Julien Buyck

Paper PosterFarnesol and geraniol loaded nanocapsules enhance the susceptibility of mcr-1 Escherichia coli to colistin – Frédéric Tewes, Chantal Valcourt, Julien Buyck, William Couet

ePoster Oral SessionA PK/PD type modelling approach to support time-kill data interpretation of cefoxitin for the treatment of Mycobacterium abscessus – Shachi Metha, Vincent Aranzana-Climent, Nicolas Grégoire, Sandrine Marchand, Julien Buyck, William Couet

Paper Poster – Use of a semi-mechanistic PK-PD model to quantify the combination effect of polymyxin B and minocycline against polymyxin-resistant Acinetobacter baumannii – Vincent Aranzana-Climent, Julien Buyck, Lena Friberg, Younes Smani, Jeronimo Pachon-Diaz, Emma Marquizeau, William Couet, Nicolas Grégoire

Paper PosterIn vitro activity of polymyxin B alone and in combination against colistin-resistant Acinetobacter baumannii Vincent Aranzana-Climent, Alexia Chauzy, Nicolas Grégoire, Sandrine Marchand, William Couet, Julien Buyck

 

ISAP 2019 – 12 April 2019 – Rotterdam


Oral presentation« PK/PD » type of modelling approach to support time-kill data interpretation of cefoxitin for the treatment of Mycobacterium abscessus – MEHTA Shachi

Oral presentationUse of a semi-mechanistic PK-PD model to quantify the combination effect of polymyxin B and minocycline against polymyxin-resistant Acinetobacter baumannii – ARANZANA-CLIMENT Vincent

RICAI 2018 – 17-18 December 2018 – Paris – France


Paper posterCinétiques d’adaptation in vitro aux antibiotiques de Pseudomonas aeruginosaEtienne Meriglier, Nicolas Grégoire, France Roblot, Sandrine Marchand, William Couet, Julien Buyck

Paper posterEtude in vitro de la réversibilité de la résistance chez Pseudomonas aeruginosaEtienne Meriglier, Nicolas Grégoire, France Roblot, Sandrine Marchand, William Couet, Julien Buyck

 

 

Joint 5th Workshop on Pulmonary Drug Delivery and 1st SimInhal Summer School – 25-27 September 2018 – Dublin – Ireland


Invited speaker – Fate of Inhaled Antibiotics – Sandrine Marchand

 

BioBarriers 2018 – 27-29 August 2018 – Saarbrücken


Paper posterAdjuvant effect of farnesol encapsulated within nanocapsules on colistin efficacy against MCR-1 E.coli – Valcourt c., Tewes F., Buyck J., Couet W.

Oral PresentationAnimal Model of Chronic Lung Infection to P. aeruginosa : Are Agar and Alginate beads interchangeable? – Frederic Tewes

 

ECCMID 2018 – 21-24 April 2018 – Madrid


Paper poster P2203 – Pulmonary disposition of oseltamivir carboxylate in rats after nebulization or intravenous
administration of its prodrug oseltamivir phosphate C. Romain, N. Gregoire, J. Brillault, I. Lamarche, P. Gobin, W. Couet, S. Marchand

Paper poster P2204 – Pulmonary pharmacokinetics of amikacin and cefoxitin after nebulization in rats S. Mehta* (Poitiers, France), I. Lamarche, C. Adier, J. Buyck, N. Gregoire, S. Marchand, W. Couet

Paper poster P2223 – Cerebrospinal fluid pharmacokinetics of ceftaroline in neurosurgical patients with externa lventricular drain P. Chavanet* (Dijon, France), A. Chauzy, N. Defrance, A. Nadji, J. Combes, W. Couet, L. Piroth

Paper poster P2230 – Microdialysis study combined with population pharmacokinetic analysis and Monte Carlo simulations for optimization of cefoxitin dosing regimen used for prophylaxis in major abdominal surgery B. Gaelzer Silva Torres* (Poitiers, France), M. Boisson, S. Yani, J. Laroche, W. Couet, O. Mimoz,
N. Gregoire, S. Marchand

Paper poster P2232 – Pharmacokinetics of colistin administered at 9MIU once daily in intensive care unit patients with preserved renal function. S. Magreault* (Poitiers, France), D. Bassoulis, N. Gregoire, A. Skiada, S. Marchand, W. Couet, G. Daikos

Paper poster P2421 – Semi-mechanistic pharmacokinetics/pharmacodynamics modelling of aztreonam-avibactam combination against multidrug-resistant Gram-negative organisms A. Chauzy* (Poitiers, France), B. Gaelzer Silva Torres, J. Buyck, E. Marquizeau, P. Gobin, B. Dejonge, S. Marchand, W. Couet, N. Gregoire

 

ECCMID 2017 – 22-25 April 2017 – Vienna


Paper poster P1214 – Microdialysis study distribution of aztreonam and avibactam in skeletal muscle and intraperitoneal fluid of rats with and without experimental peritonitis – A. Chauzy* (Poitiers, France), N. Gregoire, I. Lamarche, P. Gobin, W. Couet, S. Marchand

Invited speaker – Clinical Relevance of Protein Binding for drug Dosing – Sandrine Marchand

 

10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology – 4 – 7 April 2016 – Glasgow – UK


Invited speaker – Preliminary biopharmaceutical Classification of Antibiotics for Pulmonary Delivery – Sandrine Marchand

 

Social events


Ma Thèse en 180 secondes, March 2020

Our students are also in the first line to talk about our laboratory through different events by participating to the MT180.

 

Hariyanto Ih first participated during the 1Oth Joint Working Group Indonesia-France in Poitiers in 2018.

Then, 2 brilliant Phd students of the unit, Rana Awad and Jennifer Tardiveau, have participated this year in Poitiers

Jennifer

 


Rana


Ecole de l’ADN

In the frame of the Ecole de l’ADN, Dr. Julien Buyck is regularly interviewed by young students from high schools of the region. In January 2019 and in January 2020 they were students from Lycée Elie Vinet (Barbezieux).

Christophe Burucoa is administrator of the school of DNA Nouvelle Aquitaine, a space for initiation, information and debate on the development of life sciences. He organized courses on antibiotic resistance offered to junior high school students in the region. Three to four courses are organized each year for 12 classes.

Students and their teachers come to Poitiers for 3 days. During this stay, they are confronted with clinical cases and carry out antibiograms and PCR in search of the mecA gene to adapt the therapeutic response. They visit the Bacteriology laboratory and meet several professionals representing different research and health professions in order to help them with their professional orientation.

At a distance, a return is organized in their high school during which they will present their results of manipulation, the visit of the lab and will make posters on the professions encountered. A debate on antibiotic resistance ended the day.


Action +

For our students funded by the region Nouvelle-Aquitaine, the « scientific communication » module is mandatory. Jennifer Tardiveau have visited high schools in our region to present the researcher’s academic career and profession and the research theme of the laboratory. In November 2019, she did a visit of the Lycée Emile Roux (Confolens) and the Lycee Desfontaines (Melle).


Nuit des chercheurs, 16 October 2019, CHU Poitiers

The laboratory is also participating to the “Nuits des chercheurs” organized by the University Hospital of Poitiers each year. For one evening three weeks after the “Fête de la science”, some researchers of our unit are presenting our research activity to the public and patients in the hall of the hospital. In 2019, we realized a movie with some pictures to present the whole activities of the laboratory.


Fête de la science, Octobre 2019, EMF, Poitiers

Since 2017, the INSERM U1070 is participating to the “Fête de la science” each first weekend of October. This event takes place into the scientific conference center of Poitiers (Espace Mendès France). It consists to exposition with kind of workshops around antibioresistance and PK/PD:

  • Participants from children to adults can do a Gram staining from their own buccal swab samples to realize that bacteria are everywhere and are not necessarily bad;
  • We organized also a game board with questions around general knowledge of bacteria and antibiotics;
  • We proposed a drawing contest of bacteria for children;
  • We showed to the people how to do a good Handwashing;
  • We explained how the antibiotic is spreading into the body after administration to explain to people how important it is to take their antibiotic treatment at the right posology and for the fair duration.

 

 

Our participation in 2019 has been highlighted on the INSERM Bordeaux website :


Pint of Science, 22 May 2019

Two of our researchers have been invited to speak during the worldwide event Pint of Science. Thus, Vincent Aranzana-Climent and Dr. Julien Buyck have presented two conferences during the evening with 30 people on the theme “les antibiotiques, c’est fantastique?”.

Dr. Julien Buyck has started by a general presentation called “Et si les antibiotiques n’étaient plus efficaces demain?”, and Vincent Aranzana-Climent continued with a presentation talking about “La pharmacométrie au service de l’antibiothérapie”.

Some of our PhD students are involved in the organization of this event in Poitiers. Vincent Aranzana-Climent (in 2018), Jennifer Tardiveau and Grace Akrong (2019 and 2020) are volunteers for the organization of the Pint of Science event.

                   


Printemps de la Recherche

In April 2019, the laboratory has participated to the “Printemps de la recherche” which is organized by the University of Poitiers for Employees of the University. The lab did a presentation of the different activities and organized a visit of our facilities.


Women in Science

Some of our PhD students are visiting the High school of the Region Nouvelle-Aquitaine to talk to young students about their training courses, the researcher career and the place of women in the scientific world, in the frame of the Women in Science (now called “Sciences En Mouvement d’Elles”) event organized by Espace Mendès France. The aim is to enhance the professional careers of women and to fight against stereotypes and inequalities.

Alexia Chauzy and Sophie Magréault were visiting a High school of Niort (Lycée la Venise Verte) in March 2018.

                                         

Grace Akrong and Jennifer Tardiveau were visiting a secondary school Jean Rostand in Neuville-de-Poitou in April 2019.

                                           


Espace Mendès France

The tight relationship between our team and Espace Mendès France from Poitiers, has given numbered events like a conference from Dr. Julien Buyck and Dr. Blandine Rammaert about “Et si les antibiotiques n’étaient plus efficaces demain?”, in October 2018.

Espace Mendes France is becoming a real partner of our recent PANAMA project funded by INSERM and region Nouvelle-Aquitaine. Article in the local newspaper La Nouvelle République has been published:


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