Oral session –Characterisation of in vivo acquired ceftolozane-tazobactam resistance in Pseudomonas aeruginosa using a PKPD modelling approach – Luc Deroche
Poster –P1337: Comparison between pharmacokinetic-pharmacodynamic modelling results of ceftaroline against methicillin-resistant Staphylococcus aureus after time kill and hollow-fibre experiments – Alexia Chauzy
Poster – P1334 : In vivo pharmacokinetic-pharmacodynamic modelling of Acinetobacter baumannii inoculum effect on polymyxin B in a murine thigh infection model- Alexia Chauzy
Poster – P1343 : In vitro PK/PD modelling of polymyxin B against resistant strain of A. baumannii in presence of mucin – Mathilde Lacroix
Poster – 03559: Semi-mechanistic PKPD modelling of combined ceftazidime/avibactam and colistin against a multidrug-resistant strain of Klebsiella pneumoniae – Romain Aubry
Poster – 03484: Systematic interaction screening of ceftazidime/avibactam and colistin against eighteen carbapenem-producing Escherichia coli and Klebsiella pneumoniae strains – Romain Aubry
Poster – 03560: PEG-15-hydroxystearate non-ionic surfactant enhances amphotericin B activity against Mucorales in vitro – Kevin Brunet
Invited speaker – W0415 – The role of in vivo models – William Couet
Présentation invité – Méthodes d’études des effets combinés des antimicrobiens– Alexia Chauzy
Journées d’animation scientifiques de la FéRi, 16-17 October, Tours, France
Molecular characterisation of in vivo acquisition of ceftolozane-tazobactam and ceftazidime-avibactam resistances in a patient treated for a Pseudomonas aeruginosa infection– Luc Deroche
16e Congrès National de la SFM, 22-24 September, Nantes, France
Présentation orale – Optimisation de l’utilisation des anti-microbiens : faire plus ou faire mieux ? – Julien Buyck
Communication orale courte – Caractérisation par NGS de la diversification intra- et inter-hôte de Helicobacter pylori – Maxime Pichon
Poster – La présence de l’antigène K1 est associé à un profil d’antibiorésistance différent chez Escherichia coli – Maxime Pichon
Poster – Impact d’une pré-exposition aux antiseptiques sur l’émergence de l’antibiorésistance – Maxime Pichon
ECCMID 2021, 9-12 July 2021 – Online
E-poster – A physiologically-based pharmacokinetic model to explore the blood-milk barrier in lactating species : case study with oxytetracycline – Jennifer Tardiveau
E-poster –In vivo pk/pd analysis of the impact of the seize of the inoculum of Acinetobacter baumannii on polymyxin B – Grace Akrong
E-poster –In vitro PK/PD analysis of the impact of the size of the inoculum of Acinetobacter baumannii on polymyxin B – Grace Akrong
E-poster –HF-App, a R-Shiny web application to streamline single and dual drug hollow fiber experimental setup – Vincent Aranzana-Climent
E-poster –Pharmacokinetic/Pharmacodynamic modeling of gepotidacin against Escherichia coli and Naisseria gonorrhoeae in an in vitro hollow fiber infection model – Sandrine Marchand
E-poster – Population pharmacokinetic/pharmacodynamic study of ceftaroline after multiple doses administration in critical care patients with early-onset pneumonia and normal or augmented renal clearance – Nicolas Gregoire
E-poster –Molecular characterisation of in vivo acquisition of resistances to ceftolozane tazobactam and ceftazidime avibactam in a patient treated for a Pseudomonas aeruginosa infection – Luc Deroche
World Microbe Forum (ASM), 20-24 June 2021, Online
E-poster – Molecular Characterisation of In Vivo Acquisition of Ceftolozane-Tazobactam and Ceftazidime-Avibactam Resistances in a Patient Treated for a Pseudomonas aeruginosa Infection – Luc Deroche
E-poster –In Vitro PK/PD Analysis of the Impact of the Size of the Inoculum of Acinetobacter baumannii on Polymyxin B – Grace Akrong
E-poster – In Vivo PK/PD Analysis of the Impact of the Size of the Inoculum of Acinetobacter baumannii on Polymyxin B – Grace Akrong
Communication orale –Pharmacocinétique des antibiotiques: Quels dosages pour quels antibiotiques chez la patient âgés? – Sandrine Marchand
ECCMID 2020 – 18-21 April 2020 – Paris – France
Mini Oral flash Session –Sequential time-kill experiments to characterize lypopolysaccharide-modifying genes involved in polymyxin resistance in Escherichia coli and Klebsiella pneumoniae carrying mcr-1 – Hariyanto IH
Poster Presentation –Sequential time-kill curve to distinguish polymyxin-induced resistance and hetero-resistance in Acinetobacter baumannii – Hariyanto IHPoster Presentation – Antibacterial and anti-biofilm activity of colistinloaded nanoparticles against Acinetobacter baumannii – Rana AwadPoster Presentation – A new Lichtheimia corymbifera mouse model close to human pathophysiology to test antifungal drugs – Kevin BrunetPoster Presentation – Polyethylene glycol (15)-hydroxystearate enhances amphotericin B activity against Mucorales – Kevin BrunetPoster Presentation – In vitro model of Pseudomonas aeruginosa pulmonary biofilm to evaluate the efficacy of cationic antibiotics – Rana AwadPoster Presentation – Actinotignum schaalii in breast abscesses, an emerging pathology? Report on five cases – Luc Deroche Mini-oral ePoster Session – Comparison of patients’ brain microdialysate and cerebrospinal fluid concentrations versus time profiles of cefotaxime and metronidazole as representative antibiotic substrates or not of efflux transport systems – Alexia Chauzy
21ème Colloque français des jeunes chercheurs VLM, 14 February 2020 – Paris – France
Poster and Oral Presentation – La décolonisation par l’amphotéricine B liposomale prévient la survenue des mucormycoses pulmonaires à Lichtheimia corymbifera – Kévin Brunet, Thomas Brunet, Grégory Jouvion, Estelle Cateau, Sandrine Marchand, Blandine Rammaert
Paper Poster – Use of a semi-mechanistic PK-PD model to quantify the combination effect of polymyxin B and minocycline against polymyxin-resistant Acinetobacter baumannii – Vincent Aranzana-Climent, Julien Buyck, Lena Friberg, Younes Smani, Jeronimo Pachon-Diaz, Emma Marquizeau, William Couet, Nicolas Grégoire
Paper poster P2203 – Pulmonary disposition of oseltamivir carboxylate in rats after nebulization or intravenous
administration of its prodrug oseltamivir phosphate C. Romain, N. Gregoire, J. Brillault, I. Lamarche, P. Gobin, W. Couet, S. Marchand
Paper poster P2204 – Pulmonary pharmacokinetics of amikacin and cefoxitin after nebulization in rats S. Mehta* (Poitiers, France), I. Lamarche, C. Adier, J. Buyck, N. Gregoire, S. Marchand, W. Couet
Paper poster P2223 – Cerebrospinal fluid pharmacokinetics of ceftaroline in neurosurgical patients with externa lventricular drain P. Chavanet* (Dijon, France), A. Chauzy, N. Defrance, A. Nadji, J. Combes, W. Couet, L. Piroth
Paper poster P2230 – Microdialysis study combined with population pharmacokinetic analysis and Monte Carlo simulations for optimization of cefoxitin dosing regimen used for prophylaxis in major abdominal surgery B. Gaelzer Silva Torres* (Poitiers, France), M. Boisson, S. Yani, J. Laroche, W. Couet, O. Mimoz,
N. Gregoire, S. Marchand
Paper poster P2232 – Pharmacokinetics of colistin administered at 9MIU once daily in intensive care unit patients with preserved renal function. S. Magreault* (Poitiers, France), D. Bassoulis, N. Gregoire, A. Skiada, S. Marchand, W. Couet, G. Daikos
Paper poster P2421 – Semi-mechanistic pharmacokinetics/pharmacodynamics modelling of aztreonam-avibactam combination against multidrug-resistant Gram-negative organisms A. Chauzy* (Poitiers, France), B. Gaelzer Silva Torres, J. Buyck, E. Marquizeau, P. Gobin, B. Dejonge, S. Marchand, W. Couet, N. Gregoire
10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology – 4 – 7 April 2016 – Glasgow – UK
Invited speaker – Preliminary biopharmaceutical Classification of Antibiotics for Pulmonary Delivery – Sandrine Marchand
Fête de la Science, 2-3 October 2021, Espace Mendès France
After 1 year of absence, our laboratory made its big comeback for the 30th edition of the science festival, organized on October 2 and 3, 2021 at Espace Mendès France in Poitiers. In total, more than 250 people were welcomed by our team at the “Bacteria are resisting” stand. Through our rich and varied activities, they were able to learn more about the theme of antibiotic resistance.
A general presentation of our laboratory was permanently provided using a projected video; and explanations of the current and future context of antibiotic resistance were made using a set of posters.
Our board game version 2.0, the « Bacti’Quizz », allowed children and adults to test their knowledge in the form of a fun quiz. The questions around bacteria and antibiotics were divided into 3 categories: “Microbiology”, “Hygiene and well-being” and “History of health”.
A Gram stain from buccal swabs was offered to our little (and big) scientists. The images, captured from a microscope, were projected in order to involve children and parents. This workshop allowed them to see that bacteria are also present inside our body and that they are not dangerous for our health.
Our model Wiwi, accompanied by his poster, was also there to explain the fate of drugs in the human body. The public was able to understand why it is important to respect the dosages and to follow the treatment well until the end.
A handwashing learning workshop with a device, « la boîte à coucou », used for training of nursing staff, was available to the public. For this, the children and the parents used an ultraviolet hydro-alcoholic gel then observed their hands afterwards thanks to the blue light of the box. The public found the animation very relevant in the current context!
Great novelty for this 2021 edition: the setting up of a new workshop on DNA and PCR. The objective was to discover the structure and functioning of DNA but also to present the PCR technique and its applications in routine and research. This animation was particularly popular with children who were able to make their own DNA sequences like the famous building bricks.
A last bacteria drawing workshop was installed to allow children to have fun and relax after all these efforts.
Finally, all the participants were rewarded for their efforts by our friendly hostesses! Each child received a “young researcher” diploma as well as a gift bag filled with goodies, bacteria soft toys and other delights.
Nuit des chercheurs, 6 October 2021, CHU Poitiers
We we participated in the 4th edition of to the “Nuits des chercheurs” organized by the University Hospital of Poitiers each year.
In the frame of the Ecole de l’ADN, Dr. Julien Buyck is regularly interviewed by young students from high schools of the region. In January 2019 and in January 2020 they were students from Lycée Elie Vinet (Barbezieux).
Christophe Burucoa is administrator of the school of DNA Nouvelle Aquitaine, a space for initiation, information and debate on the development of life sciences. He organized courses on antibiotic resistance offered to junior high school students in the region. Three to four courses are organized each year for 12 classes.
Students and their teachers come to Poitiers for 3 days. During this stay, they are confronted with clinical cases and carry out antibiograms and PCR in search of the mecA gene to adapt the therapeutic response. They visit the Bacteriology laboratory and meet several professionals representing different research and health professions in order to help them with their professional orientation.
At a distance, a return is organized in their high school during which they will present their results of manipulation, the visit of the lab and will make posters on the professions encountered. A debate on antibiotic resistance ended the day.
For our students funded by the region Nouvelle-Aquitaine, the « scientific communication » module is mandatory. Jennifer Tardiveau have visited high schools in our region to present the researcher’s academic career and profession and the research theme of the laboratory. In November 2019, she did a visit of the Lycée Emile Roux (Confolens) and the Lycee Desfontaines (Melle).
Nuit des chercheurs, 16 October 2019, CHU Poitiers
The laboratory is also participating to the “Nuits des chercheurs” organized by the University Hospital of Poitiers each year. For one evening three weeks after the “Fête de la science”, some researchers of our unit are presenting our research activity to the public and patients in the hall of the hospital. In 2019, we realized a movie with some pictures to present the whole activities of the laboratory.
Fête de la science, Octobre 2019, EMF, Poitiers
Since 2017, the INSERM U1070 is participating to the “Fête de la science” each first weekend of October. This event takes place into the scientific conference center of Poitiers (Espace Mendès France). It consists to exposition with kind of workshops around antibioresistanceand PK/PD:
Participants from children to adults can do a Gram staining from their own buccal swab samples to realize that bacteria are everywhere and are not necessarily bad;
We organized also a game board with questions around general knowledge of bacteria and antibiotics;
We proposed a drawing contest of bacteria for children;
We showed to the people how to do a good Handwashing;
We explained how the antibiotic is spreading into the body after administration to explain to people how important it is to take their antibiotic treatment at the right posology and for the fair duration.
Our participation in 2019 has been highlighted on the INSERM Bordeaux website :
Pint of Science, 22 May 2019
Two of our researchers have been invited to speak during the worldwide event Pint of Science. Thus, Vincent Aranzana-Climent and Dr. Julien Buyck have presented two conferences during the evening with 30 people on the theme “les antibiotiques, c’est fantastique?”.
Dr. Julien Buyck has started by a general presentation called “Et si les antibiotiques n’étaient plus efficaces demain?”, and Vincent Aranzana-Climent continued with a presentation talking about “La pharmacométrie au service de l’antibiothérapie”.
Some of our PhD students are involved in the organization of this event in Poitiers. Vincent Aranzana-Climent (in 2018), Jennifer Tardiveau and Grace Akrong (2019 and 2020) are volunteers for the organization of the Pint of Science event.
Printemps de la Recherche
In April 2019, the laboratory has participated to the “Printemps de la recherche” which is organized by the University of Poitiers for Employees of the University. The lab did a presentation of the different activities and organized a visit of our facilities.
Women in Science
Some of our PhD students are visiting the High school of the Region Nouvelle-Aquitaine to talk to young students about their training courses, the researcher career and the place of women in the scientific world, in the frame of the Women in Science (now called “Sciences En Mouvement d’Elles”) event organized by Espace Mendès France. The aim is to enhance the professional careers of women and to fight against stereotypes and inequalities.
The tight relationship between our team and Espace Mendès France from Poitiers, has given numbered events like a conference from Dr. Julien Buyck and Dr. Blandine Rammaert about “Et si les antibiotiques n’étaient plus efficaces demain?”, in October 2018.
Espace Mendes France is becoming a real partner of our recent PANAMA project funded by INSERM and region Nouvelle-Aquitaine. Article in the local newspaper La Nouvelle République has been published: