- Associate Professor
- INSERM U1070 "Pharmacology of anti-infective agents"
Pôle Biologie Santé
1 rue Georges Bonnet
86022 Poitiers cedex
France - vincent.aranzana.climent@univ-poitiers.fr
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Vincent Aranzana-Climent
- Vincent Aranzana-Climent
Publications HAL
- Noémie Prébonnaud, Alexia Chauzy, Nicolas Grégoire, Claire Dahyot-Fizelier, Christophe Adier, et al.. A freely accessible, adaptable hollow-fiber setup to reproduce first-order absorption: illustration with linezolid cerebrospinal fluid pharmacokinetic data. Microbiology Spectrum, 2025, ⟨10.1128/spectrum.00051-25⟩. ⟨hal-05085650⟩
- Chenyan Zhao, Sanne van den Berg, Zhigang Wang, Anna Olsson, Vincent Aranzana-Climent, et al.. An integrative and translational PK/PD modelling approach to explore the combined effect of polymyxin B and minocycline against Klebsiella pneumoniae. International Journal of Antimicrobial Agents, 2025, 65 (3), pp.107443. ⟨10.1016/j.ijantimicag.2025.107443⟩. ⟨hal-05144878⟩
- Maxime Vallée, Vincent Aranzana-Climent, Jérémy Moreau, Isabelle Lamarche, Théo Fontanier, et al.. Prediction of higher ceftazidime–avibactam concentrations in the human renal interstitium compared with unbound plasma using a minimal physiologically based pharmacokinetic model developed in rats and pigs through microdialysis. Antimicrobial Agents and Chemotherapy, 2025, 69 (3), pp.e0151824. ⟨10.1128/aac.01518-24⟩. ⟨hal-04950970⟩
- Irene Hernández-Lozano, Vincent Aranzana-Climent, Sha Cao, Carina Matias, Jon Ulf Hansen, et al.. Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections. Journal of Antimicrobial Chemotherapy, 2024, Online ahead of print. ⟨10.1093/jac/dkae409⟩. ⟨hal-04800350⟩
- Théo Fontanier, Isabelle Lamarche, Céline Barc, Vincent Aranzana-Climent, Hélène Mirfendereski, et al.. Distribution tissulaire du Meropeneme-Vaborbactam dans le rein et la prostate chez le rat et le cochon sain par micro-dialyse. Progrès en Urologie - FMC, 2024, 34 (7), pp.S134-S135. ⟨10.1016/j.fpurol.2024.07.188⟩. ⟨hal-04906538⟩
- Maxime Vallée, Jérémy Moreau, Théo Fontanier, Isabelle Lamarche, Hélène Mirfendereski, et al.. Étude de la distribution tissulaire du ceftazidime-avibactam dans le parenchyme rénal de rats et de porcs par technique de micro-dialyse. Progrès en Urologie - FMC, 2024, 34 (7), pp.S127-S128. ⟨10.1016/j.fpurol.2024.07.179⟩. ⟨hal-04906357⟩
- Vincent Aranzana-Climent, Wisse van Os, Amir Nutman, Jonathan Lellouche, Yael Dishon-Benattar, et al.. Integration of individual preclinical and clinical anti‐infective PKPD data to predict clinical study outcomes. Clinical and Translational Science., 2024, 17 (7), pp.e13870. ⟨10.1111/cts.13870⟩. ⟨hal-04645902⟩
- Maxime Vallée, Jérémy Moreau, Isabelle Lamarche, Céline Barc, Nathalie Kasal-Hoc, et al.. Tissue distribution of Ceftazidime-Avibactam in kidney tissue in healthy rats and pigs using a microdialysis technique. European Urology, 2024, Abstracts EAU24 - 39th Annual EAU Congress, 85 (Supplément 1), pp.S127-S128. ⟨hal-04913348⟩
- Luc Deroche, Vincent Aranzana-Climent, Albane Rozenholc, Laure Prouvensier, Léa Darnaud, et al.. Characterization of Pseudomonas aeruginosa resistance to ceftolozane-tazobactam due to ampC and/or ampD mutations observed during treatment using semi-mechanistic PKPD modeling. Antimicrobial Agents and Chemotherapy, 2023, ⟨10.1128/aac.00480-23⟩. ⟨hal-04227340⟩
- Aart van der Meijden, Vincent Aranzana-Climent, Heleen van der Spek, Brenda de Winter, William Couet, et al.. Pharmacokinetic and pharmacodynamic properties of polymyxin B in Escherichia coli and Klebsiella pneumoniae murine infection models. Journal of Antimicrobial Chemotherapy, 2023, 78 (3), pp.832-839. ⟨10.1093/jac/dkad022⟩. ⟨hal-04088061⟩
- Vincent Aranzana-Climent, Diarmaid Hughes, Sha Cao, Magdalena Tomczak, Malgorzata Urbas, et al.. Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia. Clinical Microbiology and Infection, 2022, 28 (10), pp.1367-1374. ⟨10.1016/j.cmi.2022.05.003⟩. ⟨hal-04389011⟩
- Alexia Chauzy, Salim Bouchène, Vincent Aranzana-Climent, Jonathan Clarhaut, Christophe Adier, et al.. A Minimal Physiologically Based Pharmacokinetic Model to Characterize CNS Distribution of Metronidazole in Neuro Care ICU Patients. Antibiotics, 2022, 11 (10), pp.1293. ⟨10.3390/antibiotics11101293⟩. ⟨hal-03906712⟩
- Rakel Arrazuria, Bernhard Kerscher, Karen Huber, Jennifer Hoover, Carina Vingsbo Lundberg, et al.. Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents. Frontiers in Microbiology, 2022, 13, ⟨10.3389/fmicb.2022.988728⟩. ⟨hal-04388991⟩
- Rakel Arrazuria, Bernhard Kerscher, Karen Huber, Jennifer Hoover, Carina Vingsbo Lundberg, et al.. Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections. Frontiers in Microbiology, 2022, 13, ⟨10.3389/fmicb.2022.988725⟩. ⟨hal-04388986⟩
- Iris Minichmayr, Vincent Aranzana-Climent, Lena Friberg. Pharmacokinetic/pharmacodynamic models for time courses of antibiotic effects. International Journal of Antimicrobial Agents, 2022, 60 (3), pp.106616. ⟨10.1016/j.ijantimicag.2022.106616⟩. ⟨hal-04389002⟩
- Alexia Chauzy, Grace Akrong, Vincent Aranzana-Climent, Jérémy Moreau, Laure Prouvensier, et al.. PKPD Modeling of the Inoculum Effect of Acinetobacter baumannii on Polymyxin B in vivo. Frontiers in Pharmacology, 2022, 13, pp.842921. ⟨10.3389/fphar.2022.842921⟩. ⟨hal-03615739⟩
- Grace Akrong, Alexia Chauzy, Vincent Aranzana-Climent, Mathilde Lacroix, Luc Deroche, et al.. A New Pharmacokinetic-Pharmacodynamic Model To Characterize the Inoculum Effect of Acinetobacter baumannii on Polymyxin B In Vitro. Antimicrobial Agents and Chemotherapy, 2022, 66 (1), pp.e0178921. ⟨10.1128/AAC.01789-21⟩. ⟨hal-03615758⟩
- Katja Becker, Vincent Aranzana-Climent, Sha Cao, Anna Nilsson, Reza Shariatgorji, et al.. Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice. Clinical Microbiology and Infection, 2021, 27 (9), pp.1315-1321. ⟨10.1016/j.cmi.2020.12.004⟩. ⟨hal-04389019⟩
- Vincent Aranzana-Climent, Julien Buyck, Younes Smani, Jerónimo Pachón-Diaz, Sandrine Marchand, et al.. Semi-mechanistic PK-PD modelling of combined polymyxin B and minocycline against a polymyxin-resistant strain of Acinetobacter baumannii. Clinical Microbiology and Infection, 2020, ⟨10.1016/j.cmi.2020.01.017⟩. ⟨hal-02482129⟩
- Shachi Mehta, Vincent Aranzana-Climent, Blandine Rammaert, Nicolas Grégoire, Sandrine Marchand, et al.. Preclinical Pharmacokinetic and Pharmacodynamic Data To Support Cefoxitin Nebulization for the Treatment of Mycobacterium abscessus. Antimicrobial Agents and Chemotherapy, 2019, 63 (7), ⟨10.1128/AAC.02651-18⟩. ⟨hal-02477844⟩
- Yumi Yamamoto, Pyry Välitalo, Dirk-Jan van den Berg, Robin Hartman, Willem van den Brink, et al.. A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations. Pharmaceutical Research, 2017, 34 (2), pp.333-351. ⟨10.1007/s11095-016-2065-3⟩. ⟨hal-02472510⟩
- Nicolas Grégoire, Vincent Aranzana-Climent, Sophie Magréault, Sandrine Marchand, William Couet. Clinical Pharmacokinetics and Pharmacodynamics of Colistin. Clinical Pharmacokinetics, 2017, Epub ahead of print. ⟨10.1007/s40262-017-0561-1⟩. ⟨inserm-01528483⟩
- Noémie Prébonnaud, Alexia Chauzy, Nicolas Grégoire, Claire Dahyot-Fizelier, Christophe Adier, et al.. A freely accessible, adaptable hollow-fiber setup to reproduce first-order absorption: illustration with linezolid cerebrospinal fluid pharmacokinetic data. 2025. ⟨hal-05030769⟩
- Théo Fontanier, Isabelle Lamarche, Céline Barc, Vincent Aranzana-Climent, Hélène Mirfendereski, et al.. Distribution tissulaire du Meropeneme-Vaborbactam dans le rein et la prostate chez le rat et le cochon sain par micro-dialyse. 118e Congrès français d’urologie, Association française d'urologie (AFU), Nov 2024, Paris, France. pp.S134-S135. ⟨hal-04906501⟩
- Maxime Vallée, Jérémy Moreau, Théo Fontanier, Isabelle Lamarche, Hélène Mirfendereski, et al.. Étude de la distribution tissulaire du ceftazidime-avibactam dans le parenchyme rénal de rats et de porcs par technique de micro-dialyse. 118e Congrès français d’urologie, Association française d'urologie (AFU), Nov 2024, Paris, France. pp.S127-S128, ⟨10.1016/j.fpurol.2024.07.179⟩. ⟨hal-04906258⟩
- Maxime Vallée, Céline Barc, Jérémy Moreau, Nathalie Kasal-Hoc, Isabelle Lamarche, et al.. Tissue distribution of Ceftazidime-Avibactam in kidney tissue in healthy rats and pigs using a microdialysis technique. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain. ⟨hal-04571042⟩
- Adrien Baillod, Vincent Aranzana-Climent, Kevin Point, Sandrine Marchand, Kévin Brunet. Synergistic interaction between antifungal agents against Candida guilliermondii using pharmacodynamics-modelling approach. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain. ⟨hal-04571002⟩
- Vincent Aranzana-Climent, Valentin Al Jalali, Hwa-Ping Feng, Karen O'Dwyer, William Couet, et al.. Development and validation of a PBPK model of gepotidacin in rats to predict exposure in human prostate. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain. ⟨hal-04571063⟩
- Vincent Aranzana-Climent, Laure Prouvensier, Tom Collet, Sandrine Marchand, Nicolas Grégoire, et al.. Spotting method as a high throughput alternative to the conventional spread plating method. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain. ⟨hal-04575530⟩
- Maxime Vallée, Jérémy Moreau, Isabelle Lamarche, Céline Barc, Nathalie Kasal-Hoc, et al.. Tissue distribution of Ceftazidime-Avibactam in kidney tissue in healthy rats and pigs using a microdialysis technique. 39e Congrès de l'Association européenne d'urologie (EAU24), Apr 2024, Paris, France. , European Urology, 85 (Supplément 1), pp.S127-S128, Abstracts EAU24 - 39th Annual EAU Congress. ⟨10.1016/S0302-2838(24)00177-5⟩. ⟨hal-04906706⟩
- Vincent Aranzana-Climent. Apport de la modélisation semi-mécanistique dans l'étude pharmacocinétique/pharmacodynamique des antibiotiques seuls et en combinaison dans la lutte contre les bactéries résistantes.. Sciences du Vivant [q-bio]. Université de Poitiers (France), 2019. Français. ⟨NNT : ⟩. ⟨tel-02533266⟩
- Vincent Aranzana-Climent. Apport de la modélisation semi-mécanistique dans l'étude pharmacocinétique/pharmacodynamique des antibiotiques seuls et en combinaison dans la lutte contre les bactéries résistantes. Maladies infectieuses. Université de Poitiers, 2019. Français. ⟨NNT : 2019POIT1802⟩. ⟨tel-02535136⟩
Short CV:
Dr Vincent Aranzana-Climent undertook his doctoral studies in Poitiers, where he studied pharmacockinetic/pharmacodynamic evaluation and modelling of antimicrobial combinations. During his studies he had the opportunity to be an intern in Leiden (Netherlands) and Uppsala (Sweden) where he was a post-doctorate for 2 years, in the Pharmacometrics group before going back to Poitiers in November 2021.
His research focuses on expanding our understanding of antimicrobial therapy through pharmacometric modelling. He studies both the pharmacokinetic and pharmacodynamic aspects of therapy with a particular interest in developing methods to combine data from multiple different experiments to enable preclinical to clinical translation and model informed precision dosing.
Main recent publications:
