• Lab head (PharmD - PhD)
  • Professor of Pharmacokinetics
  • Head of the Pharmacology and toxicology hospital department
  • INSERM U1070 "Pharmacology of anti-infective agents"
    Pôle Biologie Santé
    1 rue Georges Bonnet
    86022 Poitiers cedex
    France
  • +33 (0)5 49 45 49 42
  • Research area: Pharmacokinetics

    Key words: Microdialysis, tissue distribution, aerosol, antibiotics

Publications HAL

  • Alexandre Maisterrena, Emmanuel Matas, Helene Mirfendereski, Anais Balbous, Sandrine Marchand, et al.. The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder. Biomolecules, 2022, 12 (11), pp.1691. ⟨10.3390/biom12111691⟩. ⟨hal-03906794⟩
  • Alexia Chauzy, Nicolas Gregoire, Martine Ferrandière, Sigismond Lasocki, Karim Ashenoune, et al.. Population pharmacokinetic/pharmacodynamic study suggests continuous infusion of ceftaroline daily dose in ventilated critical care patients with early-onset pneumonia and augmented renal clearance. Journal of Antimicrobial Chemotherapy, 2022, 77 (11), pp.3173-3179. ⟨10.1093/jac/dkac299⟩. ⟨hal-03906736⟩
  • Alexia Chauzy, Salim Bouchène, Vincent Aranzana-Climent, Jonathan Clarhaut, Christophe Adier, et al.. A Minimal Physiologically Based Pharmacokinetic Model to Characterize CNS Distribution of Metronidazole in Neuro Care ICU Patients. Antibiotics, 2022, 11 (10), pp.1293. ⟨10.3390/antibiotics11101293⟩. ⟨hal-03906712⟩
  • Luc Deroche, Julien Buyck, Estelle Cateau, Blandine Rammaert, Sandrine Marchand, et al.. Draft Genome Sequence of Kazachstania bovina Yeast Isolated from Human Infection. Mycopathologia, 2022, 187 (4), pp.413-415. ⟨10.1007/s11046-022-00639-4⟩. ⟨hal-03906830⟩
  • Alexia Chauzy, Grace Akrong, Vincent Aranzana-Climent, Jérémy Moreau, Laure Prouvensier, et al.. PKPD Modeling of the Inoculum Effect of Acinetobacter baumannii on Polymyxin B in vivo. Frontiers in Pharmacology, 2022, 13, ⟨10.3389/fphar.2022.842921⟩. ⟨hal-03615739⟩
  • Kévin Brunet, Jean-Philippe Martellosio, Frederic Tewes, Sandrine Marchand, Blandine Rammaert. Inhaled Antifungal Agents for Treatment and Prophylaxis of Bronchopulmonary Invasive Mold Infections. Pharmaceutics, 2022, 14 (3), pp.641. ⟨10.3390/pharmaceutics14030641⟩. ⟨hal-03626610⟩
  • Jennifer Tardiveau, Lerica Leroux-Pullen, Ronette Gehring, Gaël Touchais, Marie-Pierre Chotard, et al.. A physiologically based pharmacokinetic (PBPK) model exploring the blood-milk barrier in lactating species - A case study with oxytetracycline administered to dairy cows and goats. Food and Chemical Toxicology, 2022, 161, pp.112848. ⟨10.1016/j.fct.2022.112848⟩. ⟨hal-03615752⟩
  • Kévin Brunet, Cheikh Diop, Alexia Chauzy, Noémie Prébonnaud, Sandrine Marchand, et al.. Improved In Vitro Anti-Mucorales Activity and Cytotoxicity of Amphotericin B with a Pegylated Surfactant. Journal of Fungi, 2022, 8 (2), pp.121. ⟨10.3390/jof8020121⟩. ⟨hal-03615762⟩
  • Grace Akrong, Alexia Chauzy, Vincent Aranzana-Climent, Mathilde Lacroix, Luc Deroche, et al.. A New Pharmacokinetic-Pharmacodynamic Model To Characterize the Inoculum Effect of Acinetobacter baumannii on Polymyxin B In Vitro. Antimicrobial Agents and Chemotherapy, 2022, 66 (1), ⟨10.1128/AAC.01789-21⟩. ⟨hal-03615758⟩
  • Chantal Valcourt, Julien Buyck, Nicolas Grégoire, William Couet, Sandrine Marchand, et al.. Lipid Nanoparticles Loaded with Farnesol or Geraniol to Enhance the Susceptibility of E. coli MCR-1 to Colistin. Pharmaceutics, 2021, 13 (11), pp.1849. ⟨10.3390/pharmaceutics13111849⟩. ⟨hal-03626643⟩
  • Kévin Brunet, François Arrivé, Jean-Philippe Martellosio, Isabelle Lamarche, Sandrine Marchand, et al.. Corticosteroids alter alveolar macrophage control of Lichtheimia corymbifera spores in an ex vivo mouse model. Medical Mycology, 2021, 59 (7), pp.694-700. ⟨10.1093/mmy/myaa104⟩. ⟨hal-03464309⟩
  • Nicolas Gregoire, Alexia Chauzy, Julien Buyck, Blandine Rammaert, William Couet, et al.. Clinical Pharmacokinetics of Daptomycin. Clinical Pharmacokinetics, 2020, ⟨10.1007/s40262-020-00968-x⟩. ⟨hal-03071620⟩
  • Efstratios Mainas, Olympia Apostolopoulou, Maria Siopi, Styliani Apostolidi, Efthymios Neroutsos, et al.. Comparative pharmacokinetics of the three echinocandins in ICU patients. Journal of Antimicrobial Chemotherapy, 2020, 75 (10), pp.2969-2976. ⟨10.1093/jac/dkaa265⟩. ⟨hal-03430259⟩
  • Junwei Wang, Nicolas Grégoire, Sandrine Marchand, Jörg Kutter, Huiling Mu, et al.. Improved antibacterial efficiency of inhaled thiamphenicol dry powders: Mathematical modelling of in vitro dissolution kinetic and in vitro antibacterial efficacy. European Journal of Pharmaceutical Sciences, 2020, 152, pp.105435. ⟨10.1016/j.ejps.2020.105435⟩. ⟨hal-03430227⟩
  • Alexia Chauzy, H Ih, M Jacobs, S Marchand, N Grégoire, et al.. Sequential time-kill: a simple experimental trick to discriminate between PK/PD models with distinct heterogeneous sub-populations versus homogenous population with adaptive resistance. Antimicrobial Agents and Chemotherapy, 2020, ⟨10.1128/AAC.00788-20⟩. ⟨hal-02888859⟩
  • Frederic Tewes, Julien Brillault, Nicolas Grégoire, Jean-Christophe Olivier, Isabelle Lamarche, et al.. Comparison between Colistin Sulfate Dry Powder and Solution for Pulmonary Delivery. Pharmaceutics, 2020, 12 (6), pp.557. ⟨10.3390/pharmaceutics12060557⟩. ⟨hal-02875013⟩
  • Vincent Aranzana-Climent, Julien Buyck, Younes Smani, Jerónimo Pachón-Diaz, Sandrine Marchand, et al.. Semi-mechanistic PK-PD modelling of combined polymyxin B and minocycline against a polymyxin-resistant strain of Acinetobacter baumannii. Clinical Microbiology and Infection, 2020, ⟨10.1016/j.cmi.2020.01.017⟩. ⟨hal-02482129⟩
  • Bruna Gaelzer Silva Torres, Rana Awad, Sandrine Marchand, William Couet, Frédéric Tewes. In vitro evaluation of Pseudomonas aeruginosa chronic lung infection models: Are agar and calcium-alginate beads interchangeable?. European Journal of Pharmaceutics and Biopharmaceutics, 2019, 143, pp.35-43. ⟨10.1016/j.ejpb.2019.08.006⟩. ⟨hal-02477575⟩
  • Sophie Magréault, Julie Mankikian, Sandrine Marchand, Patrice Diot, William Couet, et al.. Pharmacokinetics of colistin after nebulization or intravenous administration of colistin methanesulphonate (Colimycin®) to cystic fibrosis patients. Journal of Cystic Fibrosis, 2019, ⟨10.1016/j.jcf.2019.08.027⟩. ⟨hal-02477383⟩
  • Alexia Chauzy, Bruna Gaelzer Silva Torres, Julien Buyck, Boudewijn Jonge, Christophe Adier, et al.. Semimechanistic Pharmacodynamic Modeling of Aztreonam‐Avibactam Combination to Understand Its Antimicrobial Activity Against Multidrug‐Resistant Gram‐Negative Bacteria. CPT: Pharmacometrics and Systems Pharmacology, 2019, ⟨10.1002/psp4.12452⟩. ⟨hal-02320523⟩
  • Thomas Brunet, Kevin Brunet, Grégory Jouvion, Estelle Cateau, Sandrine Marchand, et al.. Lichtheimia corymbifera Colonization Leading to Pulmonary Infection Can Be Prevented with Liposomal Amphotericin B in a New Murine Model. Antimicrobial Agents and Chemotherapy, 2019, 63 (8), ⟨10.1128/AAC.02544-18⟩. ⟨hal-02477834⟩
  • Sandrine Marchand, Nicolas Grégoire, William Couet. Pharmacokinetics of Polymyxins in Animals. Advances in Experimental Medicine and Biology, 2019, 1145, pp.89-103. ⟨10.1007/978-3-030-16373-0_7⟩. ⟨hal-02477604⟩
  • Matthieu Boisson, Bruna Gaelzer Silva Torres, Sabrina Yani, William Couet, Olivier Mimoz, et al.. Reassessing the dosing of cefoxitin prophylaxis during major abdominal surgery: insights from microdialysis and population pharmacokinetic modelling. Journal of Antimicrobial Chemotherapy, 2019, 74 (7), pp.1975-1983. ⟨10.1093/jac/dkz139⟩. ⟨hal-02477629⟩
  • Romain Carrez, Julien Brillault, Nicolas Grégoire, Isabelle Lamarche, Julian Laroche, et al.. Pulmonary Pharmacokinetics of Oseltamivir Carboxylate in Rats after Nebulization or Intravenous Administration of Its Prodrug, Oseltamivir Phosphate. Antimicrobial Agents and Chemotherapy, 2019, 63 (6), ⟨10.1128/AAC.00074-19⟩. ⟨hal-02477849⟩
  • Shachi Mehta, Vincent Aranzana-Climent, Blandine Rammaert, Nicolas Grégoire, Sandrine Marchand, et al.. Preclinical Pharmacokinetic and Pharmacodynamic Data To Support Cefoxitin Nebulization for the Treatment of Mycobacterium abscessus. Antimicrobial Agents and Chemotherapy, 2019, 63 (7), ⟨10.1128/AAC.02651-18⟩. ⟨hal-02477844⟩
  • Alexia Chauzy, Julien Buyck, B.L.M. de Jonge, Sandrine Marchand, N. Grégoire, et al.. Pharmacodynamic modelling of β-lactam/β-lactamase inhibitor checkerboard data: illustration with aztreonam–avibactam. Clinical Microbiology and Infection, 2019, 25 (4), pp.515.e1-515.e4. ⟨10.1016/j.cmi.2018.11.025⟩. ⟨hal-02321069⟩
  • Barbara Lamy, Dolores Remedios Serrano, Peter O’connell, William Couet, Sandrine Marchand, et al.. Use of leucine to improve aerodynamic properties of ciprofloxacin-loaded maltose microparticles for inhalation. European Journal of Pharmaceutical Research, 2019, 1 (1), pp.2-11. ⟨10.34154/2019-EJPR.01(01).pp-02-11/euraass⟩. ⟨hal-02493122⟩
  • Nicolas Grégoire, Sandrine Marchand, Martine Ferrandiere, Sigismond Lasocki, Philippe Seguin, et al.. Population pharmacokinetics of daptomycin in critically ill patients with various degrees of renal impairment. Journal of Antimicrobial Chemotherapy, 2018, 74 (1), pp.117-125. ⟨10.1093/jac/dky374⟩. ⟨hal-02477959⟩
  • Alexia Chauzy, Isabelle Lamarche, Christophe Adier, William Couet, Sandrine Marchand. Microdialysis Study of Aztreonam-Avibactam Distribution in Peritoneal Fluid and Muscle of Rats with or without Experimental Peritonitis. Antimicrobial Agents and Chemotherapy, 2018, 62 (10), ⟨10.1128/AAC.01228-18⟩. ⟨hal-02321070⟩
  • Sandrine Marchand, Matthieu Boisson, Shachi Mehta, Christophe Adier, Olivier Mimoz, et al.. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 6. Aminoglycosides. Antimicrobial Agents and Chemotherapy, 2018, 62 (10), ⟨10.1128/AAC.01261-18⟩. ⟨hal-02481204⟩
  • Salim Bouchène, Sandrine Marchand, William Couet, Lena Friberg, Patrice Gobin, et al.. A Whole-Body Physiologically Based Pharmacokinetic Model for Colistin and Colistin Methanesulfonate in Rat. Basic & Clinical Pharmacology & Toxicology, 2018, 123 (4), pp.407-422. ⟨10.1111/bcpt.13026⟩. ⟨hal-02481197⟩
  • Matthieu Boisson, Olivier Mimoz, Mirza Hadzic, Sandrine Marchand, Christophe Adier, et al.. Pharmacokinetics of intravenous and nebulized gentamicin in critically ill patients. Journal of Antimicrobial Chemotherapy, 2018, 73 (10), pp.2830-2837. ⟨10.1093/jac/dky239⟩. ⟨hal-02481185⟩
  • Siti Nurbaeti, Jean-Christophe Olivier, Christophe Adier, Sandrine Marchand, William Couet, et al.. Active Mediated Transport of Chloramphenicol and Thiamphenicol in a Calu-3 Lung Epithelial Cell Model. Journal of Pharmaceutical Sciences, 2018, 107 (4), pp.1178-1184. ⟨10.1016/j.xphs.2017.11.021⟩. ⟨hal-02481308⟩
  • Sophie Magréault, Nicolas Grégoire, Sandrine Marchand, William Couet. Colistin Pharmacokinetics in Pediatrics. Clinical Infectious Diseases, 2018, 66 (5), pp.809-809. ⟨10.1093/cid/cix1046⟩. ⟨hal-02481310⟩
  • Claire Dahyot-Fizelier, Sandrine Marchand, Jeffrey Lipman. Is augmented renal clearance the Holy Grail of antibiotic therapy failure in ventilator-acquired pneumonia?. Anaesthesia Critical Care & Pain Medicine, 2018, 37 (1), pp.5-6. ⟨10.1016/j.accpm.2017.12.003⟩. ⟨hal-02481235⟩
  • Barbara Lamy, Dolores Remedios Serrano, Isabelle Lamarche, Patrice Gobin, William Couet, et al.. New aerosol formulation to control ciprofloxacin pulmonary concentration. Journal of Controlled Release, 2017, 271, pp.118-126. ⟨10.1016/j.jconrel.2017.12.021⟩. ⟨inserm-02379277⟩
  • Matthieu Boisson, Nicolas Grégoire, Marielle Cormier, Patrice Gobin, Sandrine Marchand, et al.. Pharmacokinetics of nebulized colistin methanesulfonate in critically ill patients. Journal of Antimicrobial Chemotherapy, 2017, 72 (9), pp.2607-2612. ⟨10.1093/jac/dkx167⟩. ⟨hal-02472494⟩
  • Nicolas Grégoire, Vincent Aranzana-Climent, Sophie Magréault, Sandrine Marchand, William Couet. Clinical Pharmacokinetics and Pharmacodynamics of Colistin. Clinical Pharmacokinetics, 2017, Epub ahead of print. ⟨10.1007/s40262-017-0561-1⟩. ⟨inserm-01528483⟩
  • Marisa Gaspar, Nicolas Grégoire, João J.S. Sousa, Alberto A.C.C. Pais, Isabelle Lamarche, et al.. Pulmonary pharmacokinetics of levofloxacin in rats after aerosolization of immediate-release chitosan or sustained-release PLGA microspheres. European Journal of Pharmaceutical Sciences, 2016, 93, pp.184-191. ⟨10.1016/j.ejps.2016.08.024⟩. ⟨hal-02470904⟩
  • Sandrine Marchand, Alexia Chauzy, Claire Dahyot-Fizelier, William Couet. Microdialysis as a way to measure antibiotics concentration in tissues. Pharmacological Research, 2016, 111, pp.201-207. ⟨10.1016/j.phrs.2016.06.001⟩. ⟨hal-02321071⟩
  • Danilo Cesar Galindo Bedor, Sandrine Marchand, Isabelle Lamarche, Julian Laroche, Davi Pereira de Santana, et al.. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 5. Oseltamivir Carboxylate. Antimicrobial Agents and Chemotherapy, 2016, 60 (8), pp.5085-5087. ⟨10.1128/AAC.00909-16⟩. ⟨hal-02470855⟩
  • Sandrine Marchand, Nicolas Grégoire, Julien Brillault, Isabelle Lamarche, Patrice Gobin, et al.. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats. 4. Aztreonam. Antimicrobial Agents and Chemotherapy, 2016, 60 (5), pp.3196-3198. ⟨10.1128/AAC.00165-16⟩. ⟨hal-02470454⟩
  • Sandrine Marchand, Salim Bouchène, Michèle de Monte, Laurent Guilleminault, Jerome Montharu, et al.. Pharmacokinetics of Colistin Methansulphonate (CMS) and Colistin after CMS Nebulisation in Baboon Monkeys. Pharmaceutical Research, 2015, 32 (10), pp.3403-3414. ⟨10.1007/s11095-015-1716-0⟩. ⟨hal-02478032⟩
  • Sandrine Marchand, Nicolas Grégoire, Julien Brillault, Isabelle Lamarche, Patrice Gobin, et al.. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 3. Tobramycin. Antimicrobial Agents and Chemotherapy, 2015, 59 (10), pp.6646-6647. ⟨10.1128/AAC.01647-15⟩. ⟨hal-02477997⟩
  • Aline Vidal Lacerda Gontijo, Nicolas Grégoire, Isabelle Lamarche, Patrice Gobin, William Couet, et al.. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 2. Colistin. Antimicrobial Agents and Chemotherapy, 2014, 58 (7), pp.3950-3956. ⟨10.1128/AAC.02819-14⟩. ⟨hal-02477510⟩
  • Aline Vidal Lacerda Gontijo, Julien Brillault, Nicolas Grégoire, Isabelle Lamarche, Patrice Gobin, et al.. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 1. Ciprofloxacin, Moxifloxacin, and Grepafloxacin. Antimicrobial Agents and Chemotherapy, 2014, 58 (7), pp.3942-3949. ⟨10.1128/AAC.02818-14⟩. ⟨hal-02477506⟩
  • Carla Vitorino, Antonio Almeida, João C. Sousa, Isabelle Lamarche, Patrice Gobin, et al.. Passive and active strategies for transdermal delivery using co-encapsulating nanostructured lipid carriers: In vitro vs. in vivo studies. European Journal of Pharmaceutics and Biopharmaceutics, 2014, 86 (2), pp.133-144. ⟨10.1016/j.ejpb.2013.12.004⟩. ⟨hal-02477547⟩
  • Denis Frasca, Claire Dahyot-Fizelier, Christophe Adier, Olivier Mimoz, Bertrand Debaene, et al.. Metronidazole and Hydroxymetronidazole Central Nervous System Distribution: 2. Cerebrospinal Fluid Concentration Measurements in Patients with External Ventricular Drain. Antimicrobial Agents and Chemotherapy, 2014, 58 (2), pp.1024-1027. ⟨10.1128/AAC.01762-13⟩. ⟨hal-02477611⟩
  • Whocely Victor de Castro, Sandrine Marchand, Isabelle Lamarche, William Couet. Effect of experimentally induced hypovolemia on ertapenem tissue distribution using microdialysis in rats. European Journal of Pharmaceutical Sciences, 2014, 51, pp.45-50. ⟨10.1016/j.ejps.2013.08.017⟩. ⟨hal-02477562⟩
  • Sandrine Marchand, Maider Lauda, Gwenaël Le Moal, Patrice Gobin, William Couet, et al.. Pharmacokinetics of Daptomycin in a Patient with Severe Renal Failure Not Receiving Dialysis. Antimicrobial Agents and Chemotherapy, 2013, 57 (6), pp.2898-2899. ⟨10.1128/AAC.00230-13⟩. ⟨hal-02473937⟩
  • Claire Dahyot-Fizelier, Denis Frasca, Nicolas Grégoire, Christophe Adier, Olivier Mimoz, et al.. Microdialysis Study of Cefotaxime Cerebral Distribution in Patients with Acute Brain Injury. Antimicrobial Agents and Chemotherapy, 2013, 57 (6), pp.2738-2742. ⟨10.1128/AAC.02570-12⟩. ⟨hal-02474273⟩
  • D Frasca, C. Dahyot-Fizelier, W. Couet, B. Debaene, O. Mimoz, et al.. Brain microdialysis distribution study of cefotaxime in a patient with traumatic brain injury. British Journal of Anaesthesia, 2012, 109 (5), pp.830-831. ⟨10.1093/bja/aes369⟩. ⟨hal-02474322⟩
  • Olivier Mimoz, Franck Petitpas, Nicolas Grégoire, Patrice Gobin, Sandrine Marchand, et al.. Colistin Distribution in the Peritoneal Fluid of a Patient with Severe Peritonitis. Antimicrobial Agents and Chemotherapy, 2012, 56 (7), pp.4035-4036. ⟨10.1128/AAC.00478-12⟩. ⟨hal-02474358⟩
  • Oudy Semoun, Sandrine Marchand, Nicolas Grégoire, Isabelle Lamarche, Christophe Adier, et al.. Modeling Approach To Characterize Intraocular Doripenem Pharmacokinetics after Intravenous Administration to Rabbits, with Tentative Extrapolation to Humans. Antimicrobial Agents and Chemotherapy, 2012, 56 (7), pp.3531-3534. ⟨10.1128/AAC.06329-11⟩. ⟨hal-02474348⟩
  • Anne Jacolot, Claire Judel, Marie-Camille Chaumais, Kamel Louchahi, Patrick Nicolas, et al.. Animal Model Methodology: Immunocompetent or Leucopenic Rats, Which Is the Best Results from a Model of Experimental Pneumonia due to Derepressed Cephalosporinase-Producing Enterobacter cloacae. Chemotherapy, 2012, 58 (2), pp.129-133. ⟨10.1159/000337061⟩. ⟨hal-02474505⟩
  • W. Couet, N Grégoire, P. Gobin, P. Saulnier, D Frasca, et al.. Pharmacokinetics of Colistin and Colistimethate Sodium After a Single 80-mg Intravenous Dose of CMS in Young Healthy Volunteers. Clinical Pharmacology and Therapeutics, 2011, 89 (6), pp.875-879. ⟨10.1038/clpt.2011.48⟩. ⟨hal-02472938⟩
  • Olivier Mimoz, Stéphane Chauvet, Nicolas Grégoire, Sandrine Marchand, Marie-Emmanuelle Le Guern, et al.. Nefopam Pharmacokinetics in Patients with End-Stage Renal Disease. Anesthesia & Analgesia, 2010, 111 (5), pp.1146-1153. ⟨10.1213/ANE.0b013e3181f33488⟩. ⟨hal-02472557⟩
  • Claire Dahyot-Fizelier, Sandrine Lefeuvre, Leila Laksiri, Sandrine Marchand, Ronald Sawchuk, et al.. Kinetics of Imipenem Distribution into the Peritoneal Fluid of Patients with Severe Peritonitis Studied by Microdialysis. Clinical Pharmacokinetics, 2010, 49 (5), pp.323-334. ⟨10.2165/11319370-000000000-00000⟩. ⟨hal-02472825⟩
  • Sandrine Marchand, Denis Frasca, Claire Dahyot Fizelier, Celine Breheret, Olivier Mimoz, et al.. Lung microdialysis study of levofloxacin in rats following intravenous infusion at steady state.. Antimicrobial Agents and Chemotherapy, 2008, 52 (9), pp.3074-7. ⟨10.1128/AAC.00242-08⟩. ⟨inserm-00319455⟩
  • Sandrine Lefeuvre, Sandrine Marchand, Isabelle Lamarche, Claudine Pariat, William Couet. Microdialysis study of imipenem distribution in the peritoneal fluid of rats with experimental acute pancreatitis.. Antimicrobial Agents and Chemotherapy, 2008, 52 (4), pp.1516-8. ⟨10.1128/AAC.01474-07⟩. ⟨inserm-00319484⟩
  • Sandrine Lefeuvre, Nicolas Venisse, Sandrine Marchand, Mickael Bachelet, William Couet. A simple and sensitive liquid chromatography-tandem mass spectrometry assay for the quantification of ertapenem in microdialysate.. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 2008, 862 (1-2), pp.242-5. ⟨10.1016/j.jchromb.2007.10.047⟩. ⟨inserm-00319493⟩
  • Claire Dahyot Fizelier, Sandrine Marchand, Mickael Bodin, Bertrand Debeane, Olivier Mimoz, et al.. Application of basic pharmacokinetic concepts to analysis of microdialysis data: illustration with imipenem muscle distribution.. Clinical Pharmacokinetics, 2008, 47 (3), pp.181-9. ⟨10.2165/00003088-200847030-00004⟩. ⟨inserm-00319466⟩
  • J Karjagin, S. Lefeuvre, K Oselin, K Kipper, S Marchand, et al.. Pharmacokinetics of Meropenem Determined by Microdialysis in the Peritoneal Fluid of Patients With Severe Peritonitis Associated With Septic Shock. Clinical Pharmacology and Therapeutics, 2007, 83 (3), pp.452-459. ⟨10.1038/sj.clpt.6100312⟩. ⟨hal-02463154⟩
  • Alexia Chauzy, Arthur Fourmy, Hélène Mirfendereski, William Couet, Sandrine Marchand. Comparison between pharmacokinetic-phramcodynamic modeling results of ceftaroline against methicillin-resistant Staphylococcus aureus after Time Kill and Hollow Fiber experiments. 32nd ECCMID, Apr 2022, Lisbonne, Portugal. ⟨hal-04014948⟩
  • Mathilde Lacroix, Alexia Chauzy, Claudia Zampaloni, Caterina Bissantz, Hélène Mirfendereski, et al.. In vitro PK/PD modelling of polymyxin B against resistant strain of A. baumannii in presence of mucin. 32nd ECCMID, Apr 2022, Lisabon, Portugal. ⟨hal-04016532⟩
  • Alexia Chauzy, Salim Bouchène, Nicolas Grégoire, William Couet, Olivier Mimoz, et al.. A minimal physiologically-based pharmacokinetic model to investigate CNS distribution of metronidazole in ICU patients. 39ème Réunion Interdisciplinaire de Chimiothérapie Anti-Infectieuse (RICAI), Dec 2019, Paris, France. ⟨hal-02528416⟩
  • Alexia Chauzy, Bruna Gaelzer Silva Torres, Julien Buyck, Boudewijn Jonge, Christophe Adier, et al.. Semi-mechanistic pharmacodynamics modeling of aztreonam- avibactam combination to understand its antimicrobial activity against multidrug-resistant Gram(-) bacteria. PAGE meeting, Jun 2019, Stockholm, Sweden. ⟨hal-02528382⟩
  • Alexia Chauzy, Bruna Gaelzer Silva Torres, Julien Buyck, Emma Marquizeau, Patrice Gobin, et al.. Semi-mechanistic pharmacokinetic/pharmacodynamics modeling of aztreonam-avibactam combination against multidrug resistant Gram(-) organisms. the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2018, Madrid, Spain. ⟨hal-02528294⟩
  • Alexia Chauzy, Nicolas Grégoire, Isabelle Lamarche, Patrice Gobin, William Couet, et al.. Microdialysis study distribution of aztreonam and avibactam in skeletal muscle and intraperitoneal fluid of rats with or without experimental peritonitis. the 27th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2017, Vienne, Austria. ⟨hal-02512109⟩
  • Alexia Chauzy, Nicolas Grégoire, Sandrine Marchand, Olivier Mimoz, Marc Paccalin, et al.. Appraisal of potential effect of subcutaneous administration on antibiotics pharmacokinetics-pharmacodynamics. the 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2015, Copenhague, Denmark. ⟨hal-02512083⟩
  • Shachi Mehta, Hariyanto Ih, Blandine Rammaert, William Couet, Sandrine Marchand, et al.. In vitro evaluation of novel bi-or tri-antibiotic combination against clinical isolates of Mycobacterium abscessus. 2020. ⟨hal-03027657⟩

Short CV :

Sandrine Marchand studied Pharmacy at the University of Poitiers and obtained her Ph.D. in December 2001, during which she studied the CNS distribution of antibiotics using brain microdialysis. She becomes assistant professor in 2001 at the faculty of Pharmacy (University of Poitiers). Since 2012, she is Professor at the University of Poitiers and become in 2019 head of the department of Toxicology and Pharmacokinetics  at the University Hospital of Poitiers. She is also member for more than 15 years of the INSERM U1070 Research « Pharmacology of antimicrobial agents» a multidisciplinary group working on antibiotics PK-PD with translational approaches. Sandrine Marchand main research interest has been focusing for many years on antibiotics tissue distribution using microdialysis both in animals and human. She is now conducting research on the disposition of antimicrobial agents alone or in combination after systemic administration or nebulization to improve the treatment of severe lung infections and limit resistances and currently performing PK-PD in vivo studies in various infectious models.

Main recent publications:

     

 

 

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