• Lab head - Professor of Pharmacokinetics (PharmD - PhD)
  • Head of the Pharmacology and toxicology hospital department
  • INSERM U1070 "Pharmacology of anti-infective agents"
    Pôle Biologie Santé
    1 rue Georges Bonnet
    86022 Poitiers cedex
    France
  • +33 (0)5 49 45 49 42
  • Research area: Pharmacokinetics

    Key words: Microdialysis, tissue distribution, aerosol, antibiotics

Publications HAL

  • Noémie Prébonnaud, Alexia Chauzy, Nicolas Grégoire, Claire Dahyot-Fizelier, Christophe Adier, et al.. A freely accessible, adaptable hollow-fiber setup to reproduce first-order absorption: illustration with linezolid cerebrospinal fluid pharmacokinetic data. 2025. ⟨hal-05030769⟩
  • Shachi Mehta, Hariyanto Ih, Blandine Rammaert, William Couet, Sandrine Marchand, et al.. In vitro evaluation of novel bi-or tri-antibiotic combination against clinical isolates of Mycobacterium abscessus. 2020. ⟨hal-03027657⟩
  • Maxime Vallée, Vincent Aranzana-Climent, Jérémy Moreau, Isabelle Lamarche, Théo Fontanier, et al.. Prediction of higher ceftazidime–avibactam concentrations in the human renal interstitium compared with unbound plasma using a minimal physiologically based pharmacokinetic model developed in rats and pigs through microdialysis. Antimicrobial Agents and Chemotherapy, 2025, ⟨10.1128/aac.01518-24⟩. ⟨hal-04950970⟩
  • Luc Deroche, Albane Rozenholc, François Arrivé, Jean-Philippe Martellosio, Gwenael Le Moal, et al.. Emergence of cefiderocol resistance during therapy in NDM-5–producing Klebsiella pneumoniae isolates harboring siderophore receptors mutations. International Journal of Infectious Diseases, 2025, 151, pp.107321. ⟨10.1016/j.ijid.2024.107321⟩. ⟨hal-05023898⟩
  • Rana Awad, Sandrine Marchand, William Couet, Mohamad Nasser, Julien Buyck, et al.. Assessment of inhaled cationic antibiotics in an in vitro model of Pseudomonas aeruginosa lung biofilm. Microbial Pathogenesis, 2024, 197, pp.107020. ⟨10.1016/j.micpath.2024.107020⟩. ⟨hal-04807257⟩
  • Carla Faivre, Farras Daffa Imtiyaz, Julien Buyck, Sandrine Marchand, Melissa Marcotte, et al.. (E, E)-farnesol and myristic acid-loaded lipid nanoparticles overcome colistin resistance in Acinetobacter baumannii. International Journal of Pharmaceutics, 2024, 667 (A), pp.124907. ⟨10.1016/j.ijpharm.2024.124907⟩. ⟨hal-04766832⟩
  • Théo Fontanier, Isabelle Lamarche, Céline Barc, Vincent Aranzana-Climent, Hélène Mirfendereski, et al.. Distribution tissulaire du Meropeneme-Vaborbactam dans le rein et la prostate chez le rat et le cochon sain par micro-dialyse. Progrès en Urologie - FMC, 2024, 34 (7), pp.S134-S135. ⟨10.1016/j.fpurol.2024.07.188⟩. ⟨hal-04906538⟩
  • Maxime Vallée, Jérémy Moreau, Théo Fontanier, Isabelle Lamarche, Hélène Mirfendereski, et al.. Étude de la distribution tissulaire du ceftazidime-avibactam dans le parenchyme rénal de rats et de porcs par technique de micro-dialyse. Progrès en Urologie - FMC, 2024, 34 (7), pp.S127-S128. ⟨10.1016/j.fpurol.2024.07.179⟩. ⟨hal-04906357⟩
  • Mathilde Lacroix, Jérémy Moreau, Claudia Zampaloni, Caterina Bissantz, Hamasseh Shirvani, et al.. Impact of nutritional factors on in vitro PK/PD modelling of polymyxin B against various strains of Acinetobacter baumannii. International Journal of Antimicrobial Agents, 2024, 64 (1), pp.107189. ⟨10.1016/j.ijantimicag.2024.107189⟩. ⟨hal-04643050⟩
  • Zahyra Kaouah, Julien Buyck, Maxime Pichon, Christophe Burucoa, Laure Prouvensier, et al.. In vitro efficacy of combinations of antibiotics used in clinical practice on clinical isolates of Helicobacter pylori. Helicobacter, 2024, 29 (3), pp.e13081. ⟨10.1111/hel.13081⟩. ⟨hal-04642228⟩
  • Maxime Vallée, Jérémy Moreau, Isabelle Lamarche, Céline Barc, Nathalie Kasal-Hoc, et al.. Tissue distribution of Ceftazidime-Avibactam in kidney tissue in healthy rats and pigs using a microdialysis technique. European Urology, 2024, Abstracts EAU24 - 39th Annual EAU Congress, 85 (Supplément 1), pp.S127-S128. ⟨hal-04913348⟩
  • Jérémy Moreau, Thierry Noël, Kévin Point, Frederic Tewes, Luc Deroche, et al.. Pan-azole-resistant Meyerozyma guilliermondii clonal isolates harbouring a double F126L and L505F mutation in Erg11.. Mycoses, 2024, 67 (3), pp.e13704. ⟨10.1111/myc.13704⟩. ⟨hal-04715648⟩
  • Zahyra Kaouah, Julien Buyck, Maxime Pichon, Christophe Burucoa, Laure Prouvensier, et al.. Concentration-dependent effect of amoxicillin against clinical strains of Helicobacter pylori. Helicobacter, 2024, 29 (1), ⟨10.1111/hel.13044⟩. ⟨hal-04729706⟩
  • Frederic Tewes, Barbara Lamy, Julian Laroche, Isabelle Lamarche, Sandrine Marchand. PK-PD Evaluation of Inhaled Microparticles loaded with Ciprofloxacin-Copper complex in a Rat Model of Chronic Pseudomonas aeruginosa Lung Infection.. International Journal of Pharmaceutics: X, 2023, 5, pp.100178. ⟨10.1016/j.ijpx.2023.100178⟩. ⟨hal-04104592⟩
  • Romain Aubry, Julien Buyck, Laure Prouvensier, Jean-Winoc Decousser, Patrice Nordmann, et al.. An improved PKPD modeling approach to characterize the pharmacodynamic interaction over time between ceftazidime/avibactam and colistin from in vitro time-kill experiments against multidrug-resistant Klebsiella pneumoniae isolates. Antimicrobial Agents and Chemotherapy, 2023, 67 (10), pp.e0030123. ⟨10.1128/aac.00301-23⟩. ⟨hal-04227324⟩
  • Luc Deroche, Vincent Aranzana-Climent, Albane Rozenholc, Laure Prouvensier, Léa Darnaud, et al.. Characterization of Pseudomonas aeruginosa resistance to ceftolozane-tazobactam due to ampC and/or ampD mutations observed during treatment using semi-mechanistic PKPD modeling. Antimicrobial Agents and Chemotherapy, 2023, ⟨10.1128/aac.00480-23⟩. ⟨hal-04227340⟩
  • Luc Deroche, Julien Buyck, Estelle Cateau, Sandrine Marchand, Kévin Brunet. Draft genome sequence of the Rhinocladiella similis clinical isolate CBS 149759. Mycopathologia, 2023, ⟨10.1007/s11046-023-00715-3⟩. ⟨hal-04088324⟩
  • E. de Pablo, P. O'Connell, R. Fernández-García, S. Marchand, A. Chauzy, et al.. Targeting lung macrophages for fungal and parasitic pulmonary infections with innovative amphotericin B dry powder inhalers. International Journal of Pharmaceutics, 2023, 635, pp.122788. ⟨10.1016/j.ijpharm.2023.122788⟩. ⟨hal-04131635⟩
  • Alexandre Maisterrena, Emmanuel Matas, Helene Mirfendereski, Anais Balbous, Sandrine Marchand, et al.. The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder. Biomolecules, 2022, 12 (11), pp.1691. ⟨10.3390/biom12111691⟩. ⟨hal-03906794⟩
  • Alexia Chauzy, Nicolas Grégoire, Martine Ferrandière, Sigismond Lasocki, Karim Ashenoune, et al.. Population pharmacokinetic/pharmacodynamic study suggests continuous infusion of ceftaroline daily dose in ventilated critical care patients with early-onset pneumonia and augmented renal clearance. Journal of Antimicrobial Chemotherapy, 2022, 77 (11), pp.3173-3179. ⟨10.1093/jac/dkac299⟩. ⟨hal-03906736⟩
  • Alexia Chauzy, Salim Bouchène, Vincent Aranzana-Climent, Jonathan Clarhaut, Christophe Adier, et al.. A Minimal Physiologically Based Pharmacokinetic Model to Characterize CNS Distribution of Metronidazole in Neuro Care ICU Patients. Antibiotics, 2022, 11 (10), pp.1293. ⟨10.3390/antibiotics11101293⟩. ⟨hal-03906712⟩
  • Luc Deroche, Julien Buyck, Estelle Cateau, Blandine Rammaert, Sandrine Marchand, et al.. Draft Genome Sequence of Kazachstania bovina Yeast Isolated from Human Infection. Mycopathologia, 2022, 187 (4), pp.413-415. ⟨10.1007/s11046-022-00639-4⟩. ⟨hal-03906830⟩
  • Alexia Chauzy, Grace Akrong, Vincent Aranzana-Climent, Jérémy Moreau, Laure Prouvensier, et al.. PKPD Modeling of the Inoculum Effect of Acinetobacter baumannii on Polymyxin B in vivo. Frontiers in Pharmacology, 2022, 13, pp.842921. ⟨10.3389/fphar.2022.842921⟩. ⟨hal-03615739⟩
  • N. Layios, C. Visée, V. Mistretta, R. Denooz, N. Maes, et al.. Modelled Target Attainment after Temocillin Treatment in Severe Pneumonia: Systemic and Epithelial Lining Fluid Pharmacokinetics of Continuous versus Intermittent Infusions. Antimicrobial Agents and Chemotherapy, 2022, 66 (3), ⟨10.1128/AAC.02052-21⟩. ⟨hal-03615770⟩
  • Kévin Brunet, Jean-Philippe Martellosio, Frederic Tewes, Sandrine Marchand, Blandine Rammaert. Inhaled Antifungal Agents for Treatment and Prophylaxis of Bronchopulmonary Invasive Mold Infections. Pharmaceutics, 2022, 14 (3), pp.641. ⟨10.3390/pharmaceutics14030641⟩. ⟨hal-03626610⟩
  • Jennifer Tardiveau, Lerica Leroux-Pullen, Ronette Gehring, Gaël Touchais, Marie-Pierre Chotard, et al.. A physiologically based pharmacokinetic (PBPK) model exploring the blood-milk barrier in lactating species - A case study with oxytetracycline administered to dairy cows and goats. Food and Chemical Toxicology, 2022, 161, pp.112848. ⟨10.1016/j.fct.2022.112848⟩. ⟨hal-03615752⟩
  • Kévin Brunet, Cheikh Diop, Alexia Chauzy, Noémie Prébonnaud, Sandrine Marchand, et al.. Improved In Vitro Anti-Mucorales Activity and Cytotoxicity of Amphotericin B with a Pegylated Surfactant. Journal of Fungi, 2022, 8 (2), pp.121. ⟨10.3390/jof8020121⟩. ⟨hal-03615762⟩
  • Grace Akrong, Alexia Chauzy, Vincent Aranzana-Climent, Mathilde Lacroix, Luc Deroche, et al.. A New Pharmacokinetic-Pharmacodynamic Model To Characterize the Inoculum Effect of Acinetobacter baumannii on Polymyxin B In Vitro. Antimicrobial Agents and Chemotherapy, 2022, 66 (1), pp.e0178921. ⟨10.1128/AAC.01789-21⟩. ⟨hal-03615758⟩
  • Chantal Valcourt, Julien Buyck, Nicolas Grégoire, William Couet, Sandrine Marchand, et al.. Lipid Nanoparticles Loaded with Farnesol or Geraniol to Enhance the Susceptibility of E. coli MCR-1 to Colistin. Pharmaceutics, 2021, 13 (11), pp.1849. ⟨10.3390/pharmaceutics13111849⟩. ⟨hal-03626643⟩
  • Kévin Brunet, François Arrivé, Jean-Philippe Martellosio, Isabelle Lamarche, Sandrine Marchand, et al.. Corticosteroids alter alveolar macrophage control of Lichtheimia corymbifera spores in an ex vivo mouse model. Medical Mycology, 2021, 59 (7), pp.694-700. ⟨10.1093/mmy/myaa104⟩. ⟨hal-03464309⟩
  • Laetitia Largeaud, Pascale Cornillet-Lefebvre, Jean-François Hamel, Pierre-Yves Dumas, Naïs Prade, et al.. Lomustine is beneficial to older AML with ELN2017 adverse risk profile and intermediate karyotype: a FILO study. Leukemia, 2021, 35 (5), pp.1291-1300. ⟨10.1038/s41375-020-01031-1⟩. ⟨hal-03623649⟩
  • Nicolas Grégoire, Alexia Chauzy, Julien Buyck, Blandine Rammaert, William Couet, et al.. Clinical Pharmacokinetics of Daptomycin. Clinical Pharmacokinetics, 2020, ⟨10.1007/s40262-020-00968-x⟩. ⟨hal-03071620⟩
  • Efstratios Mainas, Olympia Apostolopoulou, Maria Siopi, Styliani Apostolidi, Efthymios Neroutsos, et al.. Comparative pharmacokinetics of the three echinocandins in ICU patients. Journal of Antimicrobial Chemotherapy, 2020, 75 (10), pp.2969-2976. ⟨10.1093/jac/dkaa265⟩. ⟨hal-03430259⟩
  • Junwei Wang, Nicolas Grégoire, Sandrine Marchand, Jörg Kutter, Huiling Mu, et al.. Improved antibacterial efficiency of inhaled thiamphenicol dry powders: Mathematical modelling of in vitro dissolution kinetic and in vitro antibacterial efficacy. European Journal of Pharmaceutical Sciences, 2020, 152, pp.105435. ⟨10.1016/j.ejps.2020.105435⟩. ⟨hal-03430227⟩
  • Alexia Chauzy, H Ih, M Jacobs, S Marchand, N Grégoire, et al.. Sequential time-kill: a simple experimental trick to discriminate between PK/PD models with distinct heterogeneous sub-populations versus homogenous population with adaptive resistance. Antimicrobial Agents and Chemotherapy, 2020, ⟨10.1128/AAC.00788-20⟩. ⟨hal-02888859⟩
  • Vincent Aranzana-Climent, Julien Buyck, Younes Smani, Jerónimo Pachón-Diaz, Sandrine Marchand, et al.. Semi-mechanistic PK-PD modelling of combined polymyxin B and minocycline against a polymyxin-resistant strain of Acinetobacter baumannii. Clinical Microbiology and Infection, 2020, ⟨10.1016/j.cmi.2020.01.017⟩. ⟨hal-02482129⟩
  • Frederic Tewes, Julien Brillault, Nicolas Grégoire, Jean-Christophe Olivier, Isabelle Lamarche, et al.. Comparison between Colistin Sulfate Dry Powder and Solution for Pulmonary Delivery. Pharmaceutics, 2020, 12 (6), pp.557. ⟨10.3390/pharmaceutics12060557⟩. ⟨hal-02875013⟩
  • Bruna Gaelzer Silva Torres, Rana Awad, Sandrine Marchand, William Couet, Frédéric Tewes. In vitro evaluation of Pseudomonas aeruginosa chronic lung infection models: Are agar and calcium-alginate beads interchangeable?. European Journal of Pharmaceutics and Biopharmaceutics, 2019, 143, pp.35-43. ⟨10.1016/j.ejpb.2019.08.006⟩. ⟨hal-02477575⟩
  • Sophie Magréault, Julie Mankikian, Sandrine Marchand, Patrice Diot, William Couet, et al.. Pharmacokinetics of colistin after nebulization or intravenous administration of colistin methanesulphonate (Colimycin®) to cystic fibrosis patients. Journal of Cystic Fibrosis, 2019, ⟨10.1016/j.jcf.2019.08.027⟩. ⟨hal-02477383⟩
  • Alexia Chauzy, Bruna Gaelzer Silva Torres, Julien Buyck, Boudewijn Jonge, Christophe Adier, et al.. Semimechanistic Pharmacodynamic Modeling of Aztreonam‐Avibactam Combination to Understand Its Antimicrobial Activity Against Multidrug‐Resistant Gram‐Negative Bacteria. CPT: Pharmacometrics and Systems Pharmacology, 2019, ⟨10.1002/psp4.12452⟩. ⟨hal-02320523⟩
  • Thomas Brunet, Kevin Brunet, Grégory Jouvion, Estelle Cateau, Sandrine Marchand, et al.. Lichtheimia corymbifera Colonization Leading to Pulmonary Infection Can Be Prevented with Liposomal Amphotericin B in a New Murine Model. Antimicrobial Agents and Chemotherapy, 2019, 63 (8), ⟨10.1128/AAC.02544-18⟩. ⟨hal-02477834⟩
  • Sandrine Marchand, Nicolas Grégoire, William Couet. Pharmacokinetics of Polymyxins in Animals. Advances in Experimental Medicine and Biology, 2019, 1145, pp.89-103. ⟨10.1007/978-3-030-16373-0_7⟩. ⟨hal-02477604⟩
  • Matthieu Boisson, Bruna Gaelzer Silva Torres, Sabrina Yani, William Couet, Olivier Mimoz, et al.. Reassessing the dosing of cefoxitin prophylaxis during major abdominal surgery: insights from microdialysis and population pharmacokinetic modelling. Journal of Antimicrobial Chemotherapy, 2019, 74 (7), pp.1975-1983. ⟨10.1093/jac/dkz139⟩. ⟨hal-02477629⟩
  • Shachi Mehta, Vincent Aranzana-Climent, Blandine Rammaert, Nicolas Grégoire, Sandrine Marchand, et al.. Preclinical Pharmacokinetic and Pharmacodynamic Data To Support Cefoxitin Nebulization for the Treatment of Mycobacterium abscessus. Antimicrobial Agents and Chemotherapy, 2019, 63 (7), ⟨10.1128/AAC.02651-18⟩. ⟨hal-02477844⟩
  • Romain Carrez, Julien Brillault, Nicolas Grégoire, Isabelle Lamarche, Julian Laroche, et al.. Pulmonary Pharmacokinetics of Oseltamivir Carboxylate in Rats after Nebulization or Intravenous Administration of Its Prodrug, Oseltamivir Phosphate. Antimicrobial Agents and Chemotherapy, 2019, 63 (6), ⟨10.1128/AAC.00074-19⟩. ⟨hal-02477849⟩
  • Alexia Chauzy, Julien Buyck, B.L.M. de Jonge, Sandrine Marchand, N. Grégoire, et al.. Pharmacodynamic modelling of β-lactam/β-lactamase inhibitor checkerboard data: illustration with aztreonam–avibactam. Clinical Microbiology and Infection, 2019, 25 (4), pp.515.e1-515.e4. ⟨10.1016/j.cmi.2018.11.025⟩. ⟨hal-02321069⟩
  • Barbara Lamy, Dolores Remedios Serrano, Peter O’connell, William Couet, Sandrine Marchand, et al.. Use of leucine to improve aerodynamic properties of ciprofloxacin-loaded maltose microparticles for inhalation. European Journal of Pharmaceutical Research, 2019, 1 (1), pp.2-11. ⟨10.34154/2019-EJPR.01(01).pp-02-11/euraass⟩. ⟨hal-02493122⟩
  • Nicolas Grégoire, Sandrine Marchand, Martine Ferrandiere, Sigismond Lasocki, Philippe Seguin, et al.. Population pharmacokinetics of daptomycin in critically ill patients with various degrees of renal impairment. Journal of Antimicrobial Chemotherapy, 2018, 74 (1), pp.117-125. ⟨10.1093/jac/dky374⟩. ⟨hal-02477959⟩
  • Alexia Chauzy, Isabelle Lamarche, Christophe Adier, William Couet, Sandrine Marchand. Microdialysis Study of Aztreonam-Avibactam Distribution in Peritoneal Fluid and Muscle of Rats with or without Experimental Peritonitis. Antimicrobial Agents and Chemotherapy, 2018, 62 (10), ⟨10.1128/AAC.01228-18⟩. ⟨hal-02321070⟩
  • Matthieu Boisson, Olivier Mimoz, Mirza Hadzic, Sandrine Marchand, Christophe Adier, et al.. Pharmacokinetics of intravenous and nebulized gentamicin in critically ill patients. Journal of Antimicrobial Chemotherapy, 2018, 73 (10), pp.2830-2837. ⟨10.1093/jac/dky239⟩. ⟨hal-02481185⟩
  • Sandrine Marchand, Matthieu Boisson, Shachi Mehta, Christophe Adier, Olivier Mimoz, et al.. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 6. Aminoglycosides. Antimicrobial Agents and Chemotherapy, 2018, 62 (10), ⟨10.1128/AAC.01261-18⟩. ⟨hal-02481204⟩
  • Salim Bouchène, Sandrine Marchand, William Couet, Lena Friberg, Patrice Gobin, et al.. A Whole-Body Physiologically Based Pharmacokinetic Model for Colistin and Colistin Methanesulfonate in Rat. Basic and Clinical Pharmacology and Toxicology, 2018, 123 (4), pp.407-422. ⟨10.1111/bcpt.13026⟩. ⟨hal-02481197⟩
  • Siti Nurbaeti, Jean-Christophe Olivier, Christophe Adier, Sandrine Marchand, William Couet, et al.. Active Mediated Transport of Chloramphenicol and Thiamphenicol in a Calu-3 Lung Epithelial Cell Model. Journal of Pharmaceutical Sciences, 2018, 107 (4), pp.1178-1184. ⟨10.1016/j.xphs.2017.11.021⟩. ⟨hal-02481308⟩
  • Sophie Magréault, Nicolas Grégoire, Sandrine Marchand, William Couet. Colistin Pharmacokinetics in Pediatrics. Clinical Infectious Diseases, 2018, 66 (5), pp.809-809. ⟨10.1093/cid/cix1046⟩. ⟨hal-02481310⟩
  • Claire Dahyot-Fizelier, Sandrine Marchand, Jeffrey Lipman. Is augmented renal clearance the Holy Grail of antibiotic therapy failure in ventilator-acquired pneumonia?. Anaesthesia Critical Care & Pain Medicine, 2018, 37 (1), pp.5-6. ⟨10.1016/j.accpm.2017.12.003⟩. ⟨hal-02481235⟩
  • Barbara Lamy, Dolores Remedios Serrano, Isabelle Lamarche, Patrice Gobin, William Couet, et al.. New aerosol formulation to control ciprofloxacin pulmonary concentration. Journal of Controlled Release, 2017, 271, pp.118-126. ⟨10.1016/j.jconrel.2017.12.021⟩. ⟨inserm-02379277⟩
  • Matthieu Boisson, Nicolas Grégoire, Marielle Cormier, Patrice Gobin, Sandrine Marchand, et al.. Pharmacokinetics of nebulized colistin methanesulfonate in critically ill patients. Journal of Antimicrobial Chemotherapy, 2017, 72 (9), pp.2607-2612. ⟨10.1093/jac/dkx167⟩. ⟨hal-02472494⟩
  • Yumi Yamamoto, Pyry Välitalo, Dirk-Jan van den Berg, Robin Hartman, Willem van den Brink, et al.. A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations. Pharmaceutical Research, 2017, 34 (2), pp.333-351. ⟨10.1007/s11095-016-2065-3⟩. ⟨hal-02472510⟩
  • Nicolas Grégoire, Vincent Aranzana-Climent, Sophie Magréault, Sandrine Marchand, William Couet. Clinical Pharmacokinetics and Pharmacodynamics of Colistin. Clinical Pharmacokinetics, 2017, Epub ahead of print. ⟨10.1007/s40262-017-0561-1⟩. ⟨inserm-01528483⟩
  • Marisa Gaspar, Nicolas Grégoire, João J.S. Sousa, Alberto A.C.C. Pais, Isabelle Lamarche, et al.. Pulmonary pharmacokinetics of levofloxacin in rats after aerosolization of immediate-release chitosan or sustained-release PLGA microspheres. European Journal of Pharmaceutical Sciences, 2016, 93, pp.184-191. ⟨10.1016/j.ejps.2016.08.024⟩. ⟨hal-02470904⟩
  • Sandrine Marchand, Alexia Chauzy, Claire Dahyot-Fizelier, William Couet. Microdialysis as a way to measure antibiotics concentration in tissues. Pharmacological Research, 2016, 111, pp.201-207. ⟨10.1016/j.phrs.2016.06.001⟩. ⟨hal-02321071⟩
  • Danilo Cesar Galindo Bedor, Sandrine Marchand, Isabelle Lamarche, Julian Laroche, Davi Pereira de Santana, et al.. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 5. Oseltamivir Carboxylate. Antimicrobial Agents and Chemotherapy, 2016, 60 (8), pp.5085-5087. ⟨10.1128/AAC.00909-16⟩. ⟨hal-02470855⟩
  • Sandrine Marchand, Nicolas Grégoire, Julien Brillault, Isabelle Lamarche, Patrice Gobin, et al.. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats. 4. Aztreonam. Antimicrobial Agents and Chemotherapy, 2016, 60 (5), pp.3196-3198. ⟨10.1128/AAC.00165-16⟩. ⟨hal-02470454⟩
  • M. Jacobs, N. Grégoire, Bruno Mégarbane, P. Gobin, D. Balayn, et al.. Population Pharmacokinetics of Colistin Methanesulfonate and Colistin in Critically Ill Patients with Acute Renal Failure Requiring Intermittent Hemodialysis. Antimicrobial Agents and Chemotherapy, 2016, 60 (3), pp.1788-1793. ⟨10.1128/AAC.01868-15⟩. ⟨hal-03860413⟩
  • Sandrine Marchand, Salim Bouchène, Michèle de Monte, Laurent Guilleminault, Jerome Montharu, et al.. Pharmacokinetics of Colistin Methansulphonate (CMS) and Colistin after CMS Nebulisation in Baboon Monkeys. Pharmaceutical Research, 2015, 32 (10), pp.3403-3414. ⟨10.1007/s11095-015-1716-0⟩. ⟨hal-02478032⟩
  • Sandrine Marchand, Nicolas Grégoire, Julien Brillault, Isabelle Lamarche, Patrice Gobin, et al.. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 3. Tobramycin. Antimicrobial Agents and Chemotherapy, 2015, 59 (10), pp.6646-6647. ⟨10.1128/AAC.01647-15⟩. ⟨hal-02477997⟩
  • N. Grégoire, O. Mimoz, Bruno Mégarbane, E. Comets, D. Chatelier, et al.. New Colistin Population Pharmacokinetic Data in Critically Ill Patients Suggesting an Alternative Loading Dose Rationale. Antimicrobial Agents and Chemotherapy, 2014, 58 (12), pp.7324-7330. ⟨10.1128/AAC.03508-14⟩. ⟨hal-03869586⟩
  • Aline Vidal Lacerda Gontijo, Nicolas Grégoire, Isabelle Lamarche, Patrice Gobin, William Couet, et al.. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 2. Colistin. Antimicrobial Agents and Chemotherapy, 2014, 58 (7), pp.3950-3956. ⟨10.1128/AAC.02819-14⟩. ⟨hal-02477510⟩
  • Aline Vidal Lacerda Gontijo, Julien Brillault, Nicolas Grégoire, Isabelle Lamarche, Patrice Gobin, et al.. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 1. Ciprofloxacin, Moxifloxacin, and Grepafloxacin. Antimicrobial Agents and Chemotherapy, 2014, 58 (7), pp.3942-3949. ⟨10.1128/AAC.02818-14⟩. ⟨hal-02477506⟩
  • Carla Vitorino, Antonio Almeida, João C. Sousa, Isabelle Lamarche, Patrice Gobin, et al.. Passive and active strategies for transdermal delivery using co-encapsulating nanostructured lipid carriers: In vitro vs. in vivo studies. European Journal of Pharmaceutics and Biopharmaceutics, 2014, 86 (2), pp.133-144. ⟨10.1016/j.ejpb.2013.12.004⟩. ⟨hal-02477547⟩
  • Denis Frasca, Claire Dahyot-Fizelier, Christophe Adier, Olivier Mimoz, Bertrand Debaene, et al.. Metronidazole and Hydroxymetronidazole Central Nervous System Distribution: 2. Cerebrospinal Fluid Concentration Measurements in Patients with External Ventricular Drain. Antimicrobial Agents and Chemotherapy, 2014, 58 (2), pp.1024-1027. ⟨10.1128/AAC.01762-13⟩. ⟨hal-02477611⟩
  • Denis Frasca, Claire Dahyot-Fizelier, Christophe Adier, Olivier Mimoz, Bertrand Debaene, et al.. Metronidazole and Hydroxymetronidazole Central Nervous System Distribution: 1. Microdialysis Assessment of Brain Extracellular Fluid Concentrations in Patients with Acute Brain Injury. Antimicrobial Agents and Chemotherapy, 2014, 58 (2), pp.1019-1023. ⟨10.1128/AAC.01760-13⟩. ⟨hal-02477606⟩
  • N. Grégoire, O. Mimoz, B. Mégarbane, E. Comets, D. Chatelier, et al.. New colistin population pharmacokinetic data in critically ill patients suggesting an alternative loading dose rationale. Antimicrobial Agents and Chemotherapy, 2014, 58 (12), pp.7324--7330. ⟨10.1128/AAC.03508-14⟩. ⟨hal-01147034⟩
  • Whocely Victor de Castro, Sandrine Marchand, Isabelle Lamarche, William Couet. Effect of experimentally induced hypovolemia on ertapenem tissue distribution using microdialysis in rats. European Journal of Pharmaceutical Sciences, 2014, 51, pp.45-50. ⟨10.1016/j.ejps.2013.08.017⟩. ⟨hal-02477562⟩
  • Anne Jacolot, Claire Judel, Kamel Louchahi, Michel Tod, Sandrine Marchand, et al.. How to solve the problem of spontaneous bacterial clearance when testing new antibiotic treatment: results on experimental pneumonia due to a derepressed cephalosporinase-producing Enterobacter cloacae. Fundamental & Clinical Pharmacology, 2013, 27 (3), pp.239-243. ⟨10.1111/j.1472-8206.2012.01026.x⟩. ⟨hal-02473941⟩
  • Sandrine Marchand, Maider Lauda, Gwenaël Le Moal, Patrice Gobin, William Couet, et al.. Pharmacokinetics of Daptomycin in a Patient with Severe Renal Failure Not Receiving Dialysis. Antimicrobial Agents and Chemotherapy, 2013, 57 (6), pp.2898-2899. ⟨10.1128/AAC.00230-13⟩. ⟨hal-02473937⟩
  • Claire Dahyot-Fizelier, Denis Frasca, Nicolas Grégoire, Christophe Adier, Olivier Mimoz, et al.. Microdialysis Study of Cefotaxime Cerebral Distribution in Patients with Acute Brain Injury. Antimicrobial Agents and Chemotherapy, 2013, 57 (6), pp.2738-2742. ⟨10.1128/AAC.02570-12⟩. ⟨hal-02474273⟩
  • Thi Viet Phuong Doan, Nicolas Grégoire, Isabelle Lamarche, Patrice Gobin, Sandrine Marchand, et al.. A preclinical pharmacokinetic modeling approach to the biopharmaceutical characterization of immediate and microsphere-based sustained release pulmonary formulations of rifampicin. European Journal of Pharmaceutical Sciences, 2013, 48 (1-2), pp.223-230. ⟨10.1016/j.ejps.2012.10.024⟩. ⟨hal-02474303⟩
  • D Frasca, C. Dahyot-Fizelier, W. Couet, B. Debaene, O. Mimoz, et al.. Brain microdialysis distribution study of cefotaxime in a patient with traumatic brain injury. British Journal of Anaesthesia, 2012, 109 (5), pp.830-831. ⟨10.1093/bja/aes369⟩. ⟨hal-02474322⟩
  • Olivier Mimoz, Franck Petitpas, Nicolas Grégoire, Patrice Gobin, Sandrine Marchand, et al.. Colistin Distribution in the Peritoneal Fluid of a Patient with Severe Peritonitis. Antimicrobial Agents and Chemotherapy, 2012, 56 (7), pp.4035-4036. ⟨10.1128/AAC.00478-12⟩. ⟨hal-02474358⟩
  • Oudy Semoun, Sandrine Marchand, Nicolas Grégoire, Isabelle Lamarche, Christophe Adier, et al.. Modeling Approach To Characterize Intraocular Doripenem Pharmacokinetics after Intravenous Administration to Rabbits, with Tentative Extrapolation to Humans. Antimicrobial Agents and Chemotherapy, 2012, 56 (7), pp.3531-3534. ⟨10.1128/AAC.06329-11⟩. ⟨hal-02474348⟩
  • Anne Jacolot, Claire Judel, Marie-Camille Chaumais, Kamel Louchahi, Patrick Nicolas, et al.. Animal Model Methodology: Immunocompetent or Leucopenic Rats, Which Is the Best Results from a Model of Experimental Pneumonia due to Derepressed Cephalosporinase-Producing Enterobacter cloacae. Chemotherapy, 2012, 58 (2), pp.129-133. ⟨10.1159/000337061⟩. ⟨hal-02474505⟩
  • W. Couet, N Grégoire, P. Gobin, P. Saulnier, D Frasca, et al.. Pharmacokinetics of Colistin and Colistimethate Sodium After a Single 80-mg Intravenous Dose of CMS in Young Healthy Volunteers. Clinical Pharmacology and Therapeutics, 2011, 89 (6), pp.875-879. ⟨10.1038/clpt.2011.48⟩. ⟨hal-02472938⟩
  • Sandrine Marchand, Isabelle Lamarche, Patrice Gobin, William Couet. Dose-ranging pharmacokinetics of colistin methanesulphonate (CMS) and colistin in rats following single intravenous CMS doses. Journal of Antimicrobial Chemotherapy, 2010, 65 (8), pp.1753-1758. ⟨10.1093/jac/dkq183⟩. ⟨hal-02472566⟩
  • Claire Dahyot-Fizelier, Sandrine Lefeuvre, Leila Laksiri, Sandrine Marchand, Ronald Sawchuk, et al.. Kinetics of Imipenem Distribution into the Peritoneal Fluid of Patients with Severe Peritonitis Studied by Microdialysis. Clinical Pharmacokinetics, 2010, 49 (5), pp.323-334. ⟨10.2165/11319370-000000000-00000⟩. ⟨hal-02472825⟩
  • Olivier Mimoz, Stéphane Chauvet, Nicolas Grégoire, Sandrine Marchand, Marie-Emmanuelle Le Guern, et al.. Nefopam Pharmacokinetics in Patients with End-Stage Renal Disease. Anesthesia & Analgesia, 2010, 111 (5), pp.1146-1153. ⟨10.1213/ANE.0b013e3181f33488⟩. ⟨hal-02472557⟩
  • Sandrine Marchand, Denis Frasca, Claire Dahyot Fizelier, Celine Breheret, Olivier Mimoz, et al.. Lung microdialysis study of levofloxacin in rats following intravenous infusion at steady state.. Antimicrobial Agents and Chemotherapy, 2008, 52 (9), pp.3074-7. ⟨10.1128/AAC.00242-08⟩. ⟨inserm-00319455⟩
  • Sandrine Lefeuvre, Sandrine Marchand, Isabelle Lamarche, Claudine Pariat, William Couet. Microdialysis study of imipenem distribution in the peritoneal fluid of rats with experimental acute pancreatitis.. Antimicrobial Agents and Chemotherapy, 2008, 52 (4), pp.1516-8. ⟨10.1128/AAC.01474-07⟩. ⟨inserm-00319484⟩
  • Sandrine Lefeuvre, Nicolas Venisse, Sandrine Marchand, Mickael Bachelet, William Couet. A simple and sensitive liquid chromatography-tandem mass spectrometry assay for the quantification of ertapenem in microdialysate.. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 2008, 862 (1-2), pp.242-5. ⟨10.1016/j.jchromb.2007.10.047⟩. ⟨inserm-00319493⟩
  • Claire Dahyot Fizelier, Sandrine Marchand, Mickael Bodin, Bertrand Debeane, Olivier Mimoz, et al.. Application of basic pharmacokinetic concepts to analysis of microdialysis data: illustration with imipenem muscle distribution.. Clinical Pharmacokinetics, 2008, 47 (3), pp.181-9. ⟨10.2165/00003088-200847030-00004⟩. ⟨inserm-00319466⟩
  • J Karjagin, S. Lefeuvre, K Oselin, K Kipper, S Marchand, et al.. Pharmacokinetics of Meropenem Determined by Microdialysis in the Peritoneal Fluid of Patients With Severe Peritonitis Associated With Septic Shock. Clinical Pharmacology and Therapeutics, 2007, 83 (3), pp.452-459. ⟨10.1038/sj.clpt.6100312⟩. ⟨hal-02463154⟩
  • Céline Brochot, S. Marchand, William Couet, Andrew Gelman, Frédéric Y. Bois. Extension of the isobolographic approach to interactions studies between more than two drugs : illustration with the convulsant interaction between pefloxacin, norfloxacin and theophylline in rats. Journal of Pharmaceutical Sciences, 2004, 93 (3), pp.553-562. ⟨10.1002/jps.10574⟩. ⟨ineris-00962878⟩
  • Maxime Vallée, Jérémy Moreau, Théo Fontanier, Isabelle Lamarche, Hélène Mirfendereski, et al.. Étude de la distribution tissulaire du ceftazidime-avibactam dans le parenchyme rénal de rats et de porcs par technique de micro-dialyse. 118e Congrès français d’urologie, Association française d'urologie (AFU), Nov 2024, Paris, France. pp.S127-S128, ⟨10.1016/j.fpurol.2024.07.179⟩. ⟨hal-04906258⟩
  • Théo Fontanier, Isabelle Lamarche, Céline Barc, Vincent Aranzana-Climent, Hélène Mirfendereski, et al.. Distribution tissulaire du Meropeneme-Vaborbactam dans le rein et la prostate chez le rat et le cochon sain par micro-dialyse. 118e Congrès français d’urologie, Association française d'urologie (AFU), Nov 2024, Paris, France. pp.S134-S135. ⟨hal-04906501⟩
  • Zahyra Kaouah, Julien Buyck, Sandrine Marchand, Christophe Burucoa, Maxime Pichon, et al.. Concentration dependent effect of amoxicillin against clinical strains of Helicobacter pylori. 30ème Réunion du Groupe d'Études Français des Helicobacter (GEFH), Jun 2023, Lille, France. ⟨hal-04142680⟩
  • Alexia Chauzy, Fanny Bernard, Nicolas Grégoire, Hélène Mirfendereski, Nadia Imzi, et al.. Pkpop-LCR study: Pharmacokinetic and Pharmacodynamic of linezolid in neurointensive care patients with external ventricular drainage. 33rd ECCMID ; European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenaghen, Denmark. ⟨hal-04142302⟩
  • Noémie Prebonnaud, Alexia Chauzy, Claire Dahyot-Fizelier, Sandrine Marchand. Predicting antibacterial efficacy of linezolid on Staphylococcus aureus in cerebral infections using in vitro hollow fiber model and pharmacokinetic-pharmacodynamic modeling. 33rd ECCMID : : European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenaghen, Denmark. ⟨hal-04142287⟩
  • Kévin Brunet, Jonathan Clarhaut, Adrien Baillod, Sandrine Marchand, Frederic Tewes. Enhancement of amphotericin B activity against Cryptococcus neoformans using lipid nanoparticles. 33rd ECCMID : European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenaghen, Denmark. ⟨hal-04142666⟩
  • Luc Deroche, François Arrivé, Jean-Philippe Martellosio, Sandrine Marchand, Julien M Buyck. Development of cefiderocol resistance during treatment in Klebsiella pneumoniae. 33rd ECCMID, Apr 2023, Copenaghen, Denmark. ⟨hal-04142293⟩
  • Mathilde Lacroix, Andrej Trauner, Claudia Zampaloni, Caterina Bissantz, Hamasseh Shirvani, et al.. Transcriptomic data to support in vitro semimechanistic PK/PD modelling of Polymyxin B against Acinetobacter baumannii. 33rd ECCMID, Apr 2023, Copenaghen, Denmark. ⟨hal-04142283⟩
  • Amandine Dubois, Mohammed Boudjarane, Anais Le Fur Bonnabesse, Gildas L'Heveder, B. Quinio, et al.. Neurophysiological mechanisms of pain in autism. IASP World Congress on Pain, Sep 2018, Boston, United States. ⟨hal-01890528⟩
  • Amandine Dubois, Mohamed Boudjarane, Anais Le Fur Bonnabesse, Céline Bodéré, G. L'Heveder, et al.. Evaluation des mécanismes neurophysiologiques de la douleur chez des adultes avec autisme sans retard mental. Xe conférence de psychologie de la santé, AFPSA, Jun 2018, Metz, France. ⟨hal-01885223⟩
  • Maxime Vallée, Céline Barc, Jérémy Moreau, Nathalie Kasal-Hoc, Isabelle Lamarche, et al.. Tissue distribution of Ceftazidime-Avibactam in kidney tissue in healthy rats and pigs using a microdialysis technique. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain. ⟨hal-04571042⟩
  • Alexia Chauzy, William Couet, Isabelle Martin, Hélène Mirfendereski, Sandrine Marchand. In vitro evaluation of the inoculum effect of various β-lactamase-producing Klebsiella pneumoniae isolates on ceftazidime-avibactam. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain. ⟨hal-04571024⟩
  • Adrien Baillod, Vincent Aranzana-Climent, Kevin Point, Sandrine Marchand, Kévin Brunet. Synergistic interaction between antifungal agents against Candida guilliermondii using pharmacodynamics-modelling approach. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain. ⟨hal-04571002⟩
  • Noémie Prébonnaud, Alexia Chauzy, Christophe Adier, Isabelle Martin, Claire Dahyot-Fizelier, et al.. Impact of in vitro use of artificial cerebrospinal fluid compared to Mueller-Hinton broth on the efficacy of linezolid against Staphylococcus aureus in a hollow-fiber model. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain. ⟨hal-04571091⟩
  • Vincent Aranzana-Climent, Valentin Al Jalali, Hwa-Ping Feng, Karen O'Dwyer, William Couet, et al.. Development and validation of a PBPK model of gepotidacin in rats to predict exposure in human prostate. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain. ⟨hal-04571063⟩
  • Vincent Aranzana-Climent, Laure Prouvensier, Tom Collet, Sandrine Marchand, Nicolas Grégoire, et al.. Spotting method as a high throughput alternative to the conventional spread plating method. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain. ⟨hal-04575530⟩
  • Vincent Aranzana-Climent, Laure Prouvensier, Tom Collet, Sandrine Marchand, Nicolas Grégoire, et al.. Spotting method as a high throughput alternative to the conventional spread plating method conventional spread plating method for bacterial time kill experiments. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain. ⟨hal-04571076⟩
  • Maxime Vallée, Jérémy Moreau, Isabelle Lamarche, Céline Barc, Nathalie Kasal-Hoc, et al.. Tissue distribution of Ceftazidime-Avibactam in kidney tissue in healthy rats and pigs using a microdialysis technique. 39e Congrès de l'Association européenne d'urologie (EAU24), Apr 2024, Paris, France. , European Urology, 85 (Supplément 1), pp.S127-S128, Abstracts EAU24 - 39th Annual EAU Congress. ⟨10.1016/S0302-2838(24)00177-5⟩. ⟨hal-04906706⟩
  • Zahyra Kaouah, Julien Buyck, Sandrine Marchand, Christophe Burucoa, Maxime Pichon, et al.. In vitro efficacy of antibiotics used in clinical practice on clinical isolates of Helicobacter pylori. 33rd ECCMID 2023: European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenhagen, Denmark. ⟨hal-04141313⟩
  • Zahyra Kaouah, Julien Buyck, Sandrine Marchand, Christophe Burucoa, Maxime Pichon, et al.. In vitro bactericidal activity of amoxicillin combined to clarithromycin or levofloxacin on clinical strains of Helicobacter pylori. 33rd ECCMID 2023: European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenaghen, Denmark. ⟨hal-04141293⟩
  • Victor Luzarraga, Maxime Pichon, Julie Cremniter, Sandrine Marchand, Julien Buyck, et al.. Validation by site-directed mutagenesis of mutations described as associated with clarithromycin resistance in Helicobacter pylori. 33rd ECCMID :: European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenaghen, Denmark. ⟨hal-04141398⟩
  • Mathilde Lacroix, Jérémy Moreau, Claudia Zampaloni, Caterina Bissantz, Hamasseh Shirvani, et al.. PK/PD modelling of the CAMHB nutrients concentrations effect on polymyxin B antimicrobial activity against Acinetobacter baumannii. 33rd ECCMID : European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenaghen, Denmark. ⟨hal-04141371⟩
  • Alexia Chauzy, Arthur Fourmy, Hélène Mirfendereski, William Couet, Sandrine Marchand. Comparison between pharmacokinetic-phramcodynamic modeling results of ceftaroline against methicillin-resistant Staphylococcus aureus after Time Kill and Hollow Fiber experiments. 32nd ECCMID, Apr 2022, Lisbonne, Portugal. ⟨hal-04014948⟩
  • Mathilde Lacroix, Alexia Chauzy, Claudia Zampaloni, Caterina Bissantz, Hélène Mirfendereski, et al.. In vitro PK/PD modelling of polymyxin B against resistant strain of A. baumannii in presence of mucin. 32nd ECCMID, Apr 2022, Lisabon, Portugal. ⟨hal-04016532⟩
  • Alexia Chauzy, Salim Bouchène, Nicolas Grégoire, William Couet, Olivier Mimoz, et al.. A minimal physiologically-based pharmacokinetic model to investigate CNS distribution of metronidazole in ICU patients. 39ème Réunion Interdisciplinaire de Chimiothérapie Anti-Infectieuse (RICAI), Dec 2019, Paris, France. ⟨hal-02528416⟩
  • Alexia Chauzy, Bruna Gaelzer Silva Torres, Julien Buyck, Boudewijn Jonge, Christophe Adier, et al.. Semi-mechanistic pharmacodynamics modeling of aztreonam- avibactam combination to understand its antimicrobial activity against multidrug-resistant Gram(-) bacteria. PAGE meeting, Jun 2019, Stockholm, Sweden. ⟨hal-02528382⟩
  • Alexia Chauzy, Bruna Gaelzer Silva Torres, Julien Buyck, Emma Marquizeau, Patrice Gobin, et al.. Semi-mechanistic pharmacokinetic/pharmacodynamics modeling of aztreonam-avibactam combination against multidrug resistant Gram(-) organisms. the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2018, Madrid, Spain. ⟨hal-02528294⟩
  • Alexia Chauzy, Nicolas Grégoire, Isabelle Lamarche, Patrice Gobin, William Couet, et al.. Microdialysis study distribution of aztreonam and avibactam in skeletal muscle and intraperitoneal fluid of rats with or without experimental peritonitis. the 27th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2017, Vienne, Austria. ⟨hal-02512109⟩
  • Alexia Chauzy, Nicolas Grégoire, Sandrine Marchand, Olivier Mimoz, Marc Paccalin, et al.. Appraisal of potential effect of subcutaneous administration on antibiotics pharmacokinetics-pharmacodynamics. the 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2015, Copenhague, Denmark. ⟨hal-02512083⟩
  • Sandrine Marchand. The Poetics of Rhythm in Jia bian and Bei hai de ren. Huang Shu-ning Sciban. Reading Wang Wenxing :Critical Essays, Cornell University, pp.256-285, 2015, 978-1939161581. ⟨hal-03600416⟩

Short CV :

Sandrine Marchand studied Pharmacy at the University of Poitiers and obtained her Ph.D. in December 2001, during which she studied the CNS distribution of antibiotics using brain microdialysis. She becomes assistant professor in 2001 at the faculty of Pharmacy (University of Poitiers). Since 2012, she is Professor at the University of Poitiers and become in 2019 head of the department of Toxicology and Pharmacokinetics  at the University Hospital of Poitiers. She is also member for more than 15 years of the INSERM U1070 Research « Pharmacology of antimicrobial agents» a multidisciplinary group working on antibiotics PK-PD with translational approaches. Sandrine Marchand main research interest has been focusing for many years on antibiotics tissue distribution using microdialysis both in animals and human. She is now conducting research on the disposition of antimicrobial agents alone or in combination after systemic administration or nebulization to improve the treatment of severe lung infections and limit resistances and currently performing PK-PD in vivo studies in various infectious models.

Main recent publications:

     

 

 

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