Nicolas Grégoire

Publications HAL

Pré-publication, Document de travail (1 document)

Noémie Prébonnaud, Alexia Chauzy, Nicolas Grégoire, Claire Dahyot-Fizelier, Christophe Adier, et al.. A freely accessible, adaptable hollow-fiber setup to reproduce first-order absorption: illustration with linezolid cerebrospinal fluid pharmacokinetic data. 2025. ⟨hal-05030769⟩

Article dans une revue (68 documents)

Zahyra Kaouah, Julien Buyck, Maxime Pichon, Christophe Burucoa, Laure Prouvensier, et al.. In vitro efficacy of combinations of antibiotics used in clinical practice on clinical isolates of Helicobacter pylori. Helicobacter, 2024, 29 (3), pp.e13081. ⟨10.1111/hel.13081⟩. ⟨hal-04642228⟩
Zahyra Kaouah, Julien Buyck, Maxime Pichon, Christophe Burucoa, Laure Prouvensier, et al.. Concentration-dependent effect of amoxicillin against clinical strains of Helicobacter pylori. Helicobacter, 2024, 29 (1), ⟨10.1111/hel.13044⟩. ⟨hal-04729706⟩
Niklas Kroemer, Lisa Amann, Aneeq Farooq, Christoph Pfaffendorf, Miklas Martens, et al.. Pharmacokinetic/pharmacodynamic analysis of ceftazidime/avibactam and fosfomycin combinations in an in vitro hollow fiber infection model against multidrug-resistant Escherichia coli. Microbiology Spectrum, 2024, 12 (1), ⟨10.1128/spectrum.03318-23⟩. ⟨hal-04473911⟩
Stephan Ehrmann, François Barbier, Julien Demiselle, Jean-Pierre Quenot, Jean-Etienne Herbrecht, et al.. Inhaled Amikacin to Prevent Ventilator-Associated Pneumonia. New England Journal of Medicine, 2023, 389 (22), pp.2052-2062. ⟨10.1056/NEJMoa2310307⟩. ⟨hal-04475709⟩
Niklas Kroemer, Miklas Martens, Jean-Winoc Decousser, Nicolas Grégoire, Patrice Nordmann, et al.. Evaluation of in vitro pharmacodynamic drug interactions of ceftazidime/avibactam and fosfomycin in Escherichia coli. Journal of Antimicrobial Chemotherapy, 2023, 78 (10), pp.2524-2534. ⟨10.1093/jac/dkad264⟩. ⟨hal-04475744⟩
Romain Aubry, Julien Buyck, Laure Prouvensier, Jean-Winoc Decousser, Patrice Nordmann, et al.. An improved PKPD modeling approach to characterize the pharmacodynamic interaction over time between ceftazidime/avibactam and colistin from in vitro time-kill experiments against multidrug-resistant Klebsiella pneumoniae isolates. Antimicrobial Agents and Chemotherapy, 2023, 67 (10), pp.e0030123. ⟨10.1128/aac.00301-23⟩. ⟨hal-04227324⟩
Luc Deroche, Vincent Aranzana-Climent, Albane Rozenholc, Laure Prouvensier, Léa Darnaud, et al.. Characterization of Pseudomonas aeruginosa resistance to ceftolozane-tazobactam due to ampC and/or ampD mutations observed during treatment using semi-mechanistic PKPD modeling. Antimicrobial Agents and Chemotherapy, 2023, ⟨10.1128/aac.00480-23⟩. ⟨hal-04227340⟩
Alexia Chauzy, Nicolas Grégoire, Martine Ferrandière, Sigismond Lasocki, Karim Ashenoune, et al.. Population pharmacokinetic/pharmacodynamic study suggests continuous infusion of ceftaroline daily dose in ventilated critical care patients with early-onset pneumonia and augmented renal clearance. Journal of Antimicrobial Chemotherapy, 2022, 77 (11), pp.3173-3179. ⟨10.1093/jac/dkac299⟩. ⟨hal-03906736⟩
Alexia Chauzy, Salim Bouchène, Vincent Aranzana-Climent, Jonathan Clarhaut, Christophe Adier, et al.. A Minimal Physiologically Based Pharmacokinetic Model to Characterize CNS Distribution of Metronidazole in Neuro Care ICU Patients. Antibiotics, 2022, 11 (10), pp.1293. ⟨10.3390/antibiotics11101293⟩. ⟨hal-03906712⟩
Niklas Kroemer, Romain Aubry, William Couet, Nicolas Grégoire, Sebastian Wicha. Optimized Rhombic Experimental Dynamic Checkerboard Designs to Elucidate Pharmacodynamic Drug Interactions of Antibiotics. Pharmaceutical Research, 2022, ⟨10.1007/s11095-022-03396-7⟩. ⟨hal-03906810⟩
N. Layios, C. Visée, V. Mistretta, R. Denooz, N. Maes, et al.. Modelled Target Attainment after Temocillin Treatment in Severe Pneumonia: Systemic and Epithelial Lining Fluid Pharmacokinetics of Continuous versus Intermittent Infusions. Antimicrobial Agents and Chemotherapy, 2022, 66 (3), ⟨10.1128/AAC.02052-21⟩. ⟨hal-03615770⟩
Jennifer Tardiveau, Lerica Leroux-Pullen, Ronette Gehring, Gaël Touchais, Marie-Pierre Chotard, et al.. A physiologically based pharmacokinetic (PBPK) model exploring the blood-milk barrier in lactating species - A case study with oxytetracycline administered to dairy cows and goats. Food and Chemical Toxicology, 2022, 161, pp.112848. ⟨10.1016/j.fct.2022.112848⟩. ⟨hal-03615752⟩
Jennifer Tardiveau, Gael Touchais, Marie-Pierre Chotard-Soutif, Marie-Pierre Lagrée, Dominique Hurtaud-Pessel, et al.. A liquid chromatography coupled to tandem mass spectrometry method for the quantification of spiramycin and its active metabolite neospiramycin in milk of major and minor species: Validation using the accuracy profile. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 2021, 1187, pp.123013. ⟨10.1016/j.jchromb.2021.123013⟩. ⟨anses-03461263⟩
Chantal Valcourt, Julien Buyck, Nicolas Grégoire, William Couet, Sandrine Marchand, et al.. Lipid Nanoparticles Loaded with Farnesol or Geraniol to Enhance the Susceptibility of E. coli MCR-1 to Colistin. Pharmaceutics, 2021, 13 (11), pp.1849. ⟨10.3390/pharmaceutics13111849⟩. ⟨hal-03626643⟩
Elsa Tavernier, Francois Barbier, Ferhat Meziani, Jean-Pierre Quenot, Jean-Etienne Herbrecht, et al.. Inhaled amikacin versus placebo to prevent ventilator-associated pneumonia: the AMIKINHAL double-blind multicentre randomised controlled trial protocol. BMJ Open, 2021, 11 (9), 10 p. ⟨10.1136/bmjopen-2020-048591⟩. ⟨hal-03371249⟩
Virgilio Hernández-Ruiz, Emmanuel Forestier, Gaëtan Gavazzi, Tristan Ferry, Nicolas Grégoire, et al.. Subcutaneous Antibiotic Therapy: The Why, How, Which Drugs and When. Journal of the American Medical Directors Association, 2021, 22 (1), pp.50-55.e6. ⟨10.1016/j.jamda.2020.04.035⟩. ⟨hal-03194481⟩
Nicolas Grégoire, Alexia Chauzy, Julien Buyck, Blandine Rammaert, William Couet, et al.. Clinical Pharmacokinetics of Daptomycin. Clinical Pharmacokinetics, 2020, ⟨10.1007/s40262-020-00968-x⟩. ⟨hal-03071620⟩
Junwei Wang, Nicolas Grégoire, Sandrine Marchand, Jörg Kutter, Huiling Mu, et al.. Improved antibacterial efficiency of inhaled thiamphenicol dry powders: Mathematical modelling of in vitro dissolution kinetic and in vitro antibacterial efficacy. European Journal of Pharmaceutical Sciences, 2020, 152, pp.105435. ⟨10.1016/j.ejps.2020.105435⟩. ⟨hal-03430227⟩
Alexia Chauzy, H Ih, M Jacobs, S Marchand, N Grégoire, et al.. Sequential time-kill: a simple experimental trick to discriminate between PK/PD models with distinct heterogeneous sub-populations versus homogenous population with adaptive resistance. Antimicrobial Agents and Chemotherapy, 2020, ⟨10.1128/AAC.00788-20⟩. ⟨hal-02888859⟩
Vincent Aranzana-Climent, Julien Buyck, Younes Smani, Jerónimo Pachón-Diaz, Sandrine Marchand, et al.. Semi-mechanistic PK-PD modelling of combined polymyxin B and minocycline against a polymyxin-resistant strain of Acinetobacter baumannii. Clinical Microbiology and Infection, 2020, ⟨10.1016/j.cmi.2020.01.017⟩. ⟨hal-02482129⟩
Frederic Tewes, Julien Brillault, Nicolas Grégoire, Jean-Christophe Olivier, Isabelle Lamarche, et al.. Comparison between Colistin Sulfate Dry Powder and Solution for Pulmonary Delivery. Pharmaceutics, 2020, 12 (6), pp.557. ⟨10.3390/pharmaceutics12060557⟩. ⟨hal-02875013⟩
B. Fantin, J. Poujade, N. Grégoire, F. Chau, A. Roujansky, et al.. The inoculum effect of Escherichia coli expressing mcr-1 or not on colistin activity in a murine model of peritonitis. Clinical Microbiology and Infection, 2019, 25 (12), pp.1563.e5-1563.e8. ⟨10.1016/j.cmi.2019.08.021⟩. ⟨hal-02477412⟩
Sophie Magréault, Julie Mankikian, Sandrine Marchand, Patrice Diot, William Couet, et al.. Pharmacokinetics of colistin after nebulization or intravenous administration of colistin methanesulphonate (Colimycin®) to cystic fibrosis patients. Journal of Cystic Fibrosis, 2019, ⟨10.1016/j.jcf.2019.08.027⟩. ⟨hal-02477383⟩
Alexia Chauzy, Bruna Gaelzer Silva Torres, Julien Buyck, Boudewijn Jonge, Christophe Adier, et al.. Semimechanistic Pharmacodynamic Modeling of Aztreonam‐Avibactam Combination to Understand Its Antimicrobial Activity Against Multidrug‐Resistant Gram‐Negative Bacteria. CPT: Pharmacometrics and Systems Pharmacology, 2019, ⟨10.1002/psp4.12452⟩. ⟨hal-02320523⟩
Sandrine Marchand, Nicolas Grégoire, William Couet. Pharmacokinetics of Polymyxins in Animals. Advances in Experimental Medicine and Biology, 2019, 1145, pp.89-103. ⟨10.1007/978-3-030-16373-0_7⟩. ⟨hal-02477604⟩
Matthieu Boisson, Bruna Gaelzer Silva Torres, Sabrina Yani, William Couet, Olivier Mimoz, et al.. Reassessing the dosing of cefoxitin prophylaxis during major abdominal surgery: insights from microdialysis and population pharmacokinetic modelling. Journal of Antimicrobial Chemotherapy, 2019, 74 (7), pp.1975-1983. ⟨10.1093/jac/dkz139⟩. ⟨hal-02477629⟩
Romain Carrez, Julien Brillault, Nicolas Grégoire, Isabelle Lamarche, Julian Laroche, et al.. Pulmonary Pharmacokinetics of Oseltamivir Carboxylate in Rats after Nebulization or Intravenous Administration of Its Prodrug, Oseltamivir Phosphate. Antimicrobial Agents and Chemotherapy, 2019, 63 (6), ⟨10.1128/AAC.00074-19⟩. ⟨hal-02477849⟩
Shachi Mehta, Vincent Aranzana-Climent, Blandine Rammaert, Nicolas Grégoire, Sandrine Marchand, et al.. Preclinical Pharmacokinetic and Pharmacodynamic Data To Support Cefoxitin Nebulization for the Treatment of Mycobacterium abscessus. Antimicrobial Agents and Chemotherapy, 2019, 63 (7), ⟨10.1128/AAC.02651-18⟩. ⟨hal-02477844⟩
Alexia Chauzy, Julien Buyck, B.L.M. de Jonge, Sandrine Marchand, N. Grégoire, et al.. Pharmacodynamic modelling of β-lactam/β-lactamase inhibitor checkerboard data: illustration with aztreonam–avibactam. Clinical Microbiology and Infection, 2019, 25 (4), pp.515.e1-515.e4. ⟨10.1016/j.cmi.2018.11.025⟩. ⟨hal-02321069⟩
Nicolas Grégoire, Sandrine Marchand, Martine Ferrandiere, Sigismond Lasocki, Philippe Seguin, et al.. Population pharmacokinetics of daptomycin in critically ill patients with various degrees of renal impairment. Journal of Antimicrobial Chemotherapy, 2018, 74 (1), pp.117-125. ⟨10.1093/jac/dky374⟩. ⟨hal-02477959⟩
Sandrine Marchand, Matthieu Boisson, Shachi Mehta, Christophe Adier, Olivier Mimoz, et al.. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 6. Aminoglycosides. Antimicrobial Agents and Chemotherapy, 2018, 62 (10), ⟨10.1128/AAC.01261-18⟩. ⟨hal-02481204⟩
Matthieu Boisson, Olivier Mimoz, Mirza Hadzic, Sandrine Marchand, Christophe Adier, et al.. Pharmacokinetics of intravenous and nebulized gentamicin in critically ill patients. Journal of Antimicrobial Chemotherapy, 2018, 73 (10), pp.2830-2837. ⟨10.1093/jac/dky239⟩. ⟨hal-02481185⟩
Salim Bouchène, Sandrine Marchand, William Couet, Lena Friberg, Patrice Gobin, et al.. A Whole-Body Physiologically Based Pharmacokinetic Model for Colistin and Colistin Methanesulfonate in Rat. Basic and Clinical Pharmacology and Toxicology, 2018, 123 (4), pp.407-422. ⟨10.1111/bcpt.13026⟩. ⟨hal-02481197⟩
S. Magréault, C. Petyt, E. Senneville, D. Fron, E. Nectoux, et al.. Pharmacokinetics of colistin in a 8-year-old child with acute bone infection. Clinical Microbiology and Infection, 2018, 24 (9), pp.1025-1026. ⟨10.1016/j.cmi.2018.04.021⟩. ⟨hal-02481212⟩
Alexis Viel, Jérôme Henri, Salim Bouchène, Julian Laroche, Jean-Guy Rolland, et al.. A Population WB-PBPK Model of Colistin and its Prodrug CMS in Pigs: Focus on the Renal Distribution and Excretion. Pharmaceutical Research, 2018, 35, pp.92. ⟨10.1007/s11095-018-2379-4⟩. ⟨anses-01743743⟩
Matthieu Grégoire, Julia Brochard Libois, Denis Waast, Benjamin Gaborit, Marc Dauty, et al.. Pharmacokinetics of Tedizolid in an Obese Patient after Bariatric Surgery. Antimicrobial Agents and Chemotherapy, 2018, 62 (4), ⟨10.1128/AAC.02432-17⟩. ⟨hal-02481229⟩
Sophie Magréault, Nicolas Grégoire, Sandrine Marchand, William Couet. Colistin Pharmacokinetics in Pediatrics. Clinical Infectious Diseases, 2018, 66 (5), pp.809-809. ⟨10.1093/cid/cix1046⟩. ⟨hal-02481310⟩
Matthieu Boisson, Nicolas Grégoire, Marielle Cormier, Patrice Gobin, Sandrine Marchand, et al.. Pharmacokinetics of nebulized colistin methanesulfonate in critically ill patients. Journal of Antimicrobial Chemotherapy, 2017, 72 (9), pp.2607-2612. ⟨10.1093/jac/dkx167⟩. ⟨hal-02472494⟩
Alexis Viel, Jérôme Henri, Agnès Perrin-Guyomard, Julian Laroche, William Couet, et al.. Lack of experimental evidence to support mcr-1- positive escherichia coli strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets. International Journal of Antimicrobial Agents, 2017, 51 (1), pp.128-131. ⟨10.1016/j.ijantimicag.2017.04.013⟩. ⟨anses-01570163⟩
Nicolas Grégoire, Vincent Aranzana-Climent, Sophie Magréault, Sandrine Marchand, William Couet. Clinical Pharmacokinetics and Pharmacodynamics of Colistin. Clinical Pharmacokinetics, 2017, Epub ahead of print. ⟨10.1007/s40262-017-0561-1⟩. ⟨inserm-01528483⟩
Marisa Gaspar, Nicolas Grégoire, João J.S. Sousa, Alberto A.C.C. Pais, Isabelle Lamarche, et al.. Pulmonary pharmacokinetics of levofloxacin in rats after aerosolization of immediate-release chitosan or sustained-release PLGA microspheres. European Journal of Pharmaceutical Sciences, 2016, 93, pp.184-191. ⟨10.1016/j.ejps.2016.08.024⟩. ⟨hal-02470904⟩
Sandrine Marchand, Nicolas Grégoire, Julien Brillault, Isabelle Lamarche, Patrice Gobin, et al.. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats. 4. Aztreonam. Antimicrobial Agents and Chemotherapy, 2016, 60 (5), pp.3196-3198. ⟨10.1128/AAC.00165-16⟩. ⟨hal-02470454⟩
Matthieu Jacobs, Nicolas Grégoire, William Couet, Jurgen B Bulitta. Distinguishing Antimicrobial Models with Different Resistance Mechanisms via Population Pharmacodynamic Modeling. PLoS Computational Biology, 2016, 12 (3), pp.e1004782. ⟨10.1371/journal.pcbi.1004782⟩. ⟨inserm-02141647⟩
M. Jacobs, N. Grégoire, Bruno Mégarbane, P. Gobin, D. Balayn, et al.. Population Pharmacokinetics of Colistin Methanesulfonate and Colistin in Critically Ill Patients with Acute Renal Failure Requiring Intermittent Hemodialysis. Antimicrobial Agents and Chemotherapy, 2016, 60 (3), pp.1788-1793. ⟨10.1128/AAC.01868-15⟩. ⟨hal-03860413⟩
M. Jacobs, N. Grégoire, B. Mégarbane, P. Gobin, D. Balayn, et al.. Population Pharmacokinetics of Colistin Methanesulfonate and Colistin in Critically Ill Patients with Acute Renal Failure Requiring Intermittent Hemodialysis. Antimicrobial Agents and Chemotherapy, 2016, 60 (3), pp.1788-1793. ⟨10.1128/AAC.01868-15⟩. ⟨hal-02470468⟩
Maja Ratajczak-Enselme, Nicolas Grégoire, Jean-Pierre Estebe, Gilles Dollo, F. Chevanne, et al.. Assessment of noninvasive acoustic respiration rate monitoring in patients admitted to an Emergency Department for drug or alcoholic poisoning. Journal of Clinical Monitoring and Computing, 2015, 29 (6), pp.721-726. ⟨10.1007/s10877-015-9658-y⟩. ⟨hal-02477941⟩
Sandrine Marchand, Salim Bouchène, Michèle de Monte, Laurent Guilleminault, Jerome Montharu, et al.. Pharmacokinetics of Colistin Methansulphonate (CMS) and Colistin after CMS Nebulisation in Baboon Monkeys. Pharmaceutical Research, 2015, 32 (10), pp.3403-3414. ⟨10.1007/s11095-015-1716-0⟩. ⟨hal-02478032⟩
Sandrine Marchand, Nicolas Grégoire, Julien Brillault, Isabelle Lamarche, Patrice Gobin, et al.. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 3. Tobramycin. Antimicrobial Agents and Chemotherapy, 2015, 59 (10), pp.6646-6647. ⟨10.1128/AAC.01647-15⟩. ⟨hal-02477997⟩
Dinh-Duy Pham, Nicolas Grégoire, William Couet, Claire Gueutin, Elias Fattal, et al.. Pulmonary delivery of pyrazinamide-loaded large porous particles. European Journal of Pharmaceutics and Biopharmaceutics, 2015, 94, pp.241-250. ⟨10.1016/j.ejpb.2015.05.021⟩. ⟨hal-02478095⟩
Maja Ratajczak-Enselme, Nicolas Grégoire, Jean-Pierre Estebe, Gilles Dollo, F. Chevanne, et al.. Population Pharmacokinetics of Amitriptyline After Intrathecal, Epidural, and Intravenous Administration in Sheep:. Regional Anesthesia and Pain Medicine, 2015, 40 (6), pp.681--686. ⟨10.1097/AAP.0000000000000322⟩. ⟨hal-01282359⟩
N. Grégoire, O. Mimoz, Bruno Mégarbane, E. Comets, D. Chatelier, et al.. New Colistin Population Pharmacokinetic Data in Critically Ill Patients Suggesting an Alternative Loading Dose Rationale. Antimicrobial Agents and Chemotherapy, 2014, 58 (12), pp.7324-7330. ⟨10.1128/AAC.03508-14⟩. ⟨hal-03869586⟩
B. Mégarbane, E. Comets, D. Chatelier, S. Lasocki, R. Gauzit, et al.. Comparison of Intrapulmonary and Systemic Pharmacokinetics of Colistin Methanesulfonate (CMS) and Colistin after Aerosol Delivery and Intravenous Administration of CMS in Critically Ill Patients. Antimicrobial Agents and Chemotherapy, 2014, 58 (12), pp.7331-7339. ⟨10.1128/AAC.03510-14⟩. ⟨hal-02477453⟩
Aline Vidal Lacerda Gontijo, Nicolas Grégoire, Isabelle Lamarche, Patrice Gobin, William Couet, et al.. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 2. Colistin. Antimicrobial Agents and Chemotherapy, 2014, 58 (7), pp.3950-3956. ⟨10.1128/AAC.02819-14⟩. ⟨hal-02477510⟩
Aline Vidal Lacerda Gontijo, Julien Brillault, Nicolas Grégoire, Isabelle Lamarche, Patrice Gobin, et al.. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 1. Ciprofloxacin, Moxifloxacin, and Grepafloxacin. Antimicrobial Agents and Chemotherapy, 2014, 58 (7), pp.3942-3949. ⟨10.1128/AAC.02818-14⟩. ⟨hal-02477506⟩
N. Grégoire, O. Mimoz, B. Mégarbane, E. Comets, D. Chatelier, et al.. New colistin population pharmacokinetic data in critically ill patients suggesting an alternative loading dose rationale. Antimicrobial Agents and Chemotherapy, 2014, 58 (12), pp.7324--7330. ⟨10.1128/AAC.03508-14⟩. ⟨hal-01147034⟩
Claire Dahyot-Fizelier, Denis Frasca, Nicolas Grégoire, Christophe Adier, Olivier Mimoz, et al.. Microdialysis Study of Cefotaxime Cerebral Distribution in Patients with Acute Brain Injury. Antimicrobial Agents and Chemotherapy, 2013, 57 (6), pp.2738-2742. ⟨10.1128/AAC.02570-12⟩. ⟨hal-02474273⟩
M Boisson, N. Grégoire, W. Couet, O. Mimoz. Colistin in critically ill patients.. Minerva Anestesiologica, 2013, 79 (2), pp.200-8. ⟨hal-02483131⟩
Thi Viet Phuong Doan, Nicolas Grégoire, Isabelle Lamarche, Patrice Gobin, Sandrine Marchand, et al.. A preclinical pharmacokinetic modeling approach to the biopharmaceutical characterization of immediate and microsphere-based sustained release pulmonary formulations of rifampicin. European Journal of Pharmaceutical Sciences, 2013, 48 (1-2), pp.223-230. ⟨10.1016/j.ejps.2012.10.024⟩. ⟨hal-02474303⟩
Olivier Mimoz, Franck Petitpas, Nicolas Grégoire, Patrice Gobin, Sandrine Marchand, et al.. Colistin Distribution in the Peritoneal Fluid of a Patient with Severe Peritonitis. Antimicrobial Agents and Chemotherapy, 2012, 56 (7), pp.4035-4036. ⟨10.1128/AAC.00478-12⟩. ⟨hal-02474358⟩
Oudy Semoun, Sandrine Marchand, Nicolas Grégoire, Isabelle Lamarche, Christophe Adier, et al.. Modeling Approach To Characterize Intraocular Doripenem Pharmacokinetics after Intravenous Administration to Rabbits, with Tentative Extrapolation to Humans. Antimicrobial Agents and Chemotherapy, 2012, 56 (7), pp.3531-3534. ⟨10.1128/AAC.06329-11⟩. ⟨hal-02474348⟩
Olivier Mimoz, Nicolas Grégoire, Laurent Poirel, Manuella Marliat, William Couet, et al.. Broad-Spectrum β-Lactam Antibiotics for Treating Experimental Peritonitis in Mice Due to Klebsiella pneumoniae Producing the Carbapenemase OXA-48. Antimicrobial Agents and Chemotherapy, 2012, 56 (5), pp.2759-2760. ⟨10.1128/AAC.06069-11⟩. ⟨hal-02474380⟩
A. Veinstein, O. Debouverie, N. Grégoire, V. Goudet, C. Adier, et al.. Lack of effect of extracorporeal membrane oxygenation on tigecycline pharmacokinetics. Journal of Antimicrobial Chemotherapy, 2012, 67 (4), pp.1047-1048. ⟨10.1093/jac/dkr550⟩. ⟨hal-02474484⟩
W. Couet, N. Grégoire, S. Marchand, O. Mimoz. Colistin pharmacokinetics: the fog is lifting. Clinical Microbiology and Infection, 2012, 18 (1), pp.30-39. ⟨10.1111/j.1469-0691.2011.03667.x⟩. ⟨hal-02474468⟩
Herbert Spapen, Patrick Honore, Nicolas Grégoire, Patrice Gobin, Jouke de Regt, et al.. Convulsions and apnoea in a patient infected with New Delhi metallo-β-lactamase-1 Escherichia coli treated with colistin. Journal of Infection, 2011, 63 (6), pp.468-470. ⟨10.1016/j.jinf.2011.07.008⟩. ⟨hal-02472872⟩
W. Couet, N Grégoire, P. Gobin, P. Saulnier, D Frasca, et al.. Pharmacokinetics of Colistin and Colistimethate Sodium After a Single 80-mg Intravenous Dose of CMS in Young Healthy Volunteers. Clinical Pharmacology and Therapeutics, 2011, 89 (6), pp.875-879. ⟨10.1038/clpt.2011.48⟩. ⟨hal-02472938⟩
Nicolas Grégoire, Sophie Raherison, Claire Grignon, Emmanuelle Comets, Manuella Marliat, et al.. Semimechanistic pharmacokinetic-pharmacodynamic model with adaptation development for time-kill experiments of ciprofloxacin against Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 2010, 54 (6), pp.2379-2384. ⟨10.1128/AAC.01478-08⟩. ⟨inserm-00533219⟩
Olivier Mimoz, Stéphane Chauvet, Nicolas Grégoire, Sandrine Marchand, Marie-Emmanuelle Le Guern, et al.. Nefopam Pharmacokinetics in Patients with End-Stage Renal Disease. Anesthesia & Analgesia, 2010, 111 (5), pp.1146-1153. ⟨10.1213/ANE.0b013e3181f33488⟩. ⟨hal-02472557⟩
N. Venisse, N. Gregoire, M. Marliat, W. Couet. Mechanism-Based Pharmacokinetic-Pharmacodynamic Models of In Vitro Fungistatic and Fungicidal Effects against Candida albicans. Antimicrobial Agents and Chemotherapy, 2008, 52 (3), pp.937-943. ⟨10.1128/AAC.01030-07⟩. ⟨hal-02463067⟩

Poster (11 documents)

Vincent Aranzana-Climent, Laure Prouvensier, Tom Collet, Sandrine Marchand, Nicolas Grégoire, et al.. Spotting method as a high throughput alternative to the conventional spread plating method. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain. ⟨hal-04575530⟩
Vincent Aranzana-Climent, Laure Prouvensier, Tom Collet, Sandrine Marchand, Nicolas Grégoire, et al.. Spotting method as a high throughput alternative to the conventional spread plating method conventional spread plating method for bacterial time kill experiments. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain. ⟨hal-04571076⟩
Abderrahmane Meslouh, Alexis Viel, Nicolas Grégoire. PBPK modeling to explore dairy cows’ exposure to marbofloxacin and estimate milk withdrawal period. GMP 2023 Symposium, Oct 2023, Paris, France. . ⟨hal-04533797⟩
Zahyra Kaouah, Julien Buyck, Sandrine Marchand, Christophe Burucoa, Maxime Pichon, et al.. In vitro efficacy of antibiotics used in clinical practice on clinical isolates of Helicobacter pylori. 33rd ECCMID 2023: European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenhagen, Denmark. ⟨hal-04141313⟩
Zahyra Kaouah, Julien Buyck, Sandrine Marchand, Christophe Burucoa, Maxime Pichon, et al.. In vitro bactericidal activity of amoxicillin combined to clarithromycin or levofloxacin on clinical strains of Helicobacter pylori. 33rd ECCMID 2023: European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenaghen, Denmark. ⟨hal-04141293⟩
Alexia Chauzy, Salim Bouchène, Nicolas Grégoire, William Couet, Olivier Mimoz, et al.. A minimal physiologically-based pharmacokinetic model to investigate CNS distribution of metronidazole in ICU patients. 39ème Réunion Interdisciplinaire de Chimiothérapie Anti-Infectieuse (RICAI), Dec 2019, Paris, France. ⟨hal-02528416⟩
Alexia Chauzy, Bruna Gaelzer Silva Torres, Julien Buyck, Boudewijn Jonge, Christophe Adier, et al.. Semi-mechanistic pharmacodynamics modeling of aztreonam- avibactam combination to understand its antimicrobial activity against multidrug-resistant Gram(-) bacteria. PAGE meeting, Jun 2019, Stockholm, Sweden. ⟨hal-02528382⟩
Alexis Viel, Jérôme Henri, Agnès Perrin-Guyomard, Julian Laroche, William Couet, et al.. Lack of experimental evidence to support mcr-1-positive Escherichia coli strain selection during oral administration of colistin by gavage in weaned piglets. 14th international congress of the European association for veterinary pharmacology and toxicology, Jun 2018, Wroclaw, Poland. . ⟨anses-01985196⟩
Alexia Chauzy, Bruna Gaelzer Silva Torres, Julien Buyck, Emma Marquizeau, Patrice Gobin, et al.. Semi-mechanistic pharmacokinetic/pharmacodynamics modeling of aztreonam-avibactam combination against multidrug resistant Gram(-) organisms. the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2018, Madrid, Spain. ⟨hal-02528294⟩
Alexia Chauzy, Nicolas Grégoire, Isabelle Lamarche, Patrice Gobin, William Couet, et al.. Microdialysis study distribution of aztreonam and avibactam in skeletal muscle and intraperitoneal fluid of rats with or without experimental peritonitis. the 27th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2017, Vienne, Austria. ⟨hal-02512109⟩
Alexia Chauzy, Nicolas Grégoire, Sandrine Marchand, Olivier Mimoz, Marc Paccalin, et al.. Appraisal of potential effect of subcutaneous administration on antibiotics pharmacokinetics-pharmacodynamics. the 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2015, Copenhague, Denmark. ⟨hal-02512083⟩

Communication dans un congrès (2 documents)

Zahyra Kaouah, Julien Buyck, Sandrine Marchand, Christophe Burucoa, Maxime Pichon, et al.. Concentration dependent effect of amoxicillin against clinical strains of Helicobacter pylori. 30ème Réunion du Groupe d'Études Français des Helicobacter (GEFH), Jun 2023, Lille, France. ⟨hal-04142680⟩
Alexia Chauzy, Fanny Bernard, Nicolas Grégoire, Hélène Mirfendereski, Nadia Imzi, et al.. Pkpop-LCR study: Pharmacokinetic and Pharmacodynamic of linezolid in neurointensive care patients with external ventricular drainage. 33rd ECCMID ; European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenaghen, Denmark. ⟨hal-04142302⟩

Short CV:

Dr. Nicolas Grégoire (born 20.11.1972, France) is Assistant Professor of Pharmacometrics at the University of Poitiers, School of Medicine and Pharmacy. He has joined the unit UMR 1070 « Pharmacology of Antimicrobial Agents » in 2008 in order to develop PK and PK/PD models for anti-infective drugs.
He is a recognized expert in pharmacometry with more than 50 peer-reviewed publications, 3 book chapters and 3 oral communications in international meetings. He is familiar with non-linear mixed effect models, population PK, non-compartmental PK analysis, PBPK models and PK/PD models. Before working in UMR 1070, he has worked as PK project manager at SGS life Science.
He has supervised 6 already defended PhD and is currently supervising 2 PHD students. Among other projects, he has been involved in a JPIAMR project (Co-Action) and 2 IMI projects (Combacte Care and AB-direct).

Main recent publications:

Find me on…

Accès directs

Menu principal

Nicolas Grégoire

Publications HAL