• Associate Professor in Biopharmacy
  • INSERM U1070 "Pharmacology of anti-infective agents"
    Pôle Biologie Santé
    1 rue Georges Bonnet
    86022 Poitiers cedex
    France
  • (33) 5 49 36 49 29
  • Research area: Pharmaceutics – pharmaceutical technology

    Key words: Drug delivery – inhalation – aerosol- microparticle – nanoparticle

Publications HAL

  • Kévin Brunet, Jean-Philippe Martellosio, Frederic Tewes, Sandrine Marchand, Blandine Rammaert. Inhaled Antifungal Agents for Treatment and Prophylaxis of Bronchopulmonary Invasive Mold Infections. Pharmaceutics, MDPI, 2022, 14 (3), pp.641. ⟨10.3390/pharmaceutics14030641⟩. ⟨hal-03626610⟩
  • Kévin Brunet, Cheikh Diop, Alexia Chauzy, Noémie Prébonnaud, Sandrine Marchand, et al.. Improved In Vitro Anti-Mucorales Activity and Cytotoxicity of Amphotericin B with a Pegylated Surfactant. Journal of Fungi, MDPI, 2022, 8 (2), pp.121. ⟨10.3390/jof8020121⟩. ⟨hal-03615762⟩
  • Chantal Valcourt, Julien Buyck, Nicolas Grégoire, William Couet, Sandrine Marchand, et al.. Lipid Nanoparticles Loaded with Farnesol or Geraniol to Enhance the Susceptibility of E. coli MCR-1 to Colistin. Pharmaceutics, MDPI, 2021, 13 (11), pp.1849. ⟨10.3390/pharmaceutics13111849⟩. ⟨hal-03626643⟩
  • Julien Brillault, Frederic Tewes. Control of the Lung Residence Time of Highly Permeable Molecules after Nebulization: Example of the Fluoroquinolones. Pharmaceutics, MDPI, 2020, 12 (4), pp.E387. ⟨10.3390/pharmaceutics12040387⟩. ⟨inserm-02558855⟩
  • Frederic Tewes, Julien Brillault, Nicolas Grégoire, Jean-Christophe Olivier, Isabelle Lamarche, et al.. Comparison between Colistin Sulfate Dry Powder and Solution for Pulmonary Delivery. Pharmaceutics, MDPI, 2020, 12 (6), pp.557. ⟨10.3390/pharmaceutics12060557⟩. ⟨hal-02875013⟩
  • Bruna Gaelzer Silva Torres, Rana Awad, Sandrine Marchand, William Couet, Frédéric Tewes. In vitro evaluation of Pseudomonas aeruginosa chronic lung infection models: Are agar and calcium-alginate beads interchangeable?. European Journal of Pharmaceutics and Biopharmaceutics, Elsevier, 2019, 143, pp.35-43. ⟨10.1016/j.ejpb.2019.08.006⟩. ⟨hal-02477575⟩
  • Siti Nani Nurbaeti, Julien Brillault, Frédéric Tewes, Jean-Christophe Olivier. Sustained-release microparticle dry powders of chloramphenicol palmitate or thiamphenicol palmitate prodrugs for lung delivery as aerosols. European Journal of Pharmaceutical Sciences, Elsevier, 2019, 138, pp.105028. ⟨10.1016/j.ejps.2019.105028⟩. ⟨hal-02477590⟩
  • Frédéric Tewes, Tania Bahamondez-Canas, Hugh Smyth. Efficacy of Ciprofloxacin and Its Copper Complex against Pseudomonas aeruginosa Biofilms. AAPS PharmSciTech, American Association of Pharmaceutical Scientists, 2019, 20 (5), pp.205. ⟨10.1208/s12249-019-1417-9⟩. ⟨hal-02477817⟩
  • Barbara Lamy, Dolores Remedios Serrano, Peter O’connell, William Couet, Sandrine Marchand, et al.. Use of leucine to improve aerodynamic properties of ciprofloxacin-loaded maltose microparticles for inhalation. European Journal of Pharmaceutical Research, European Academy of Applied and Social Sciences, 2019, 1 (1), pp.2-11. ⟨10.34154/2019-EJPR.01(01).pp-02-11/euraass⟩. ⟨hal-02493122⟩
  • Tania Bahamondez-Canas, Hairui Zhang, Frederic Tewes, Jasmim Leal, Hugh Smyth. PEGylation of Tobramycin Improves Mucus Penetration and Antimicrobial Activity against Pseudomonas aeruginosa Biofilms in Vitro. Molecular Pharmaceutics, American Chemical Society, 2018, 15 (4), pp.1643-1652. ⟨10.1021/acs.molpharmaceut.8b00011⟩. ⟨inserm-02379306⟩
  • Barbara Lamy, Dolores Serrano, Isabelle Lamarche, Patrice Gobin, William Couet, et al.. New aerosol formulation to control ciprofloxacin pulmonary concentration. Journal of Controlled Release, Elsevier, 2017, 271, pp.118-126. ⟨10.1016/j.jconrel.2017.12.021⟩. ⟨inserm-02379277⟩
  • Julien Brillault, Frédéric Tewes, William Couet, Jean-Christophe Olivier. In vitro biopharmaceutical evaluation of ciprofloxacin/metal cation complexes for pulmonary administration.. European Journal of Pharmaceutical Sciences, Elsevier, 2017, 97, pp.92-98. ⟨10.1016/j.ejps.2016.11.011⟩. ⟨inserm-01416565⟩
  • Frederic Tewes, Oliviero Gobbo, Carsten Ehrhardt, Anne Healy. Amorphous calcium carbonate based-microparticles for peptide pulmonary delivery. ACS Applied Materials & Interfaces, Washington, D.C. : American Chemical Society, 2015, 8 (2), pp.1164-1175. ⟨10.1021/acsami.5b09023⟩. ⟨inserm-01375596⟩
  • Frédéric Tewes, Oliviero Gobbo, Carsten Ehrhardt, Anne Healy. Amorphous Calcium Carbonate Based-Microparticles for Peptide Pulmonary Delivery. ACS Applied Materials & Interfaces, Washington, D.C. : American Chemical Society, 2015, 2016, 8 (2), pp.1164-1175. ⟨10.1021/acsami.5b09023⟩. ⟨hal-02484982⟩
  • Frederic Tewes, Julien Brillault, Barbara Lamy, Peter O 'Connell, Jean-Christophe Olivier, et al.. Ciprofloxacin-Loaded Inorganic–Organic Composite Microparticles To Treat Bacterial Lung Infection. Molecular Pharmaceutics, American Chemical Society, 2015, 13 ((1)), pp.100-112. ⟨10.1021/acs.molpharmaceut.5b00543⟩. ⟨inserm-01373710⟩
  • Marisa Gaspar, João J.S. Sousa, Alberto A.C.C. Pais, Olga Cardoso, Dina Murtinho, et al.. Optimization of levofloxacin-loaded crosslinked chitosan microspheres for inhaled aerosol therapy. European Journal of Pharmaceutics and Biopharmaceutics, Elsevier, 2015, 96, pp.65-75. ⟨10.1016/j.ejpb.2015.07.010⟩. ⟨hal-02478056⟩
  • Maria Inês Amaro, Frédéric Tewes, Oliviero Gobbo, Lidia Tajber, Owen Corrigan, et al.. Formulation, stability and pharmacokinetics of sugar-based salmon calcitonin-loaded nanoporous/nanoparticulate microparticles (NPMPs) for inhalation. International Journal of Pharmaceutics, Elsevier, 2015, 483 (1-2), pp.6-18. ⟨10.1016/j.ijpharm.2015.02.003⟩. ⟨hal-02484990⟩
  • M.-K. Tran, L.N. Hassani, B. Calvignac, Thomas Beuvier, Frédéric Tewes, et al.. Corrigendum to “Lysozyme encapsulation within PLGA and CaCO3 microparticles using supercritical CO2 medium” [J. Supercrit. Fluids 79 (2013) 159–169]. Journal of Supercritical Fluids, Elsevier, 2014, 88, pp.142. ⟨10.1016/j.supflu.2014.02.018⟩. ⟨hal-02484969⟩
  • Janani Swaminathan, Oliviero Gobbo, Frédéric Tewes, Anne Marie Healy, Carsten Ehrhardt. Encapsulation into PEG-Liposomes Does Not Improve the Bioavailability of Pulmonary Delivered Salmon Calcitonin. JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 2014, 27 (1), pp.1-11. ⟨10.1089/jamp.2013.1049⟩. ⟨hal-02484995⟩
  • Frederic Tewes, Carsten Ehrhardt, Anne Marie Healy. Superparamagnetic iron oxide nanoparticles (SPIONs)-loaded Trojan microparticles for targeted aerosol delivery to the lung. European Journal of Pharmaceutics and Biopharmaceutics, Elsevier, 2014, 86, pp.98 - 104. ⟨10.1016/j.ejpb.2013.09.004⟩. ⟨inserm-01102561⟩
  • Frederic Tewes, Krzysztof Paluch, Lidia Tajber, Karan Gulati, Devesh Kalantri, et al.. Steroid/mucokinetic hybrid nanoporous microparticles for pulmonary drug delivery. European Journal of Pharmaceutics and Biopharmaceutics, Elsevier, 2013, 85 (3), pp.604-613. ⟨10.1016/j.ejpb.2013.03.020⟩. ⟨inserm-01102852⟩
  • Stefano Bianco, Frederic Tewes, Lidia Tajber, Vincent Caron, Owen Corrigan, et al.. Bulk, surface properties and water uptake mechanisms of salt/acid amorphous composite systems. International Journal of Pharmaceutics, Elsevier, 2013, 456 (1), pp.143-152. ⟨10.1016/j.ijpharm.2013.07.076⟩. ⟨inserm-01102838⟩
  • Oliviero Gobbo, Magdalena Zurek, Frédéric Tewes, Carsten Ehrhardt, Yannick Crémillieux. Manganese: a new contrast agent for lung imaging?. Contrast Media & Molecular Imaging, 2012, 7 (6), pp.542-546. ⟨10.1002/cmmi.1483⟩. ⟨hal-02485025⟩
  • Leonie Baginski, Oliviero Gobbo, Frédéric Tewes, Johanna Salomon, Anne Marie Healy, et al.. In Vitro and In Vivo Characterisation of PEG-Lipid-Based Micellar Complexes of Salmon Calcitonin for Pulmonary Delivery. Pharmaceutical Research, American Association of Pharmaceutical Scientists, 2012, 29 (6), pp.1425-1434. ⟨10.1007/s11095-012-0688-6⟩. ⟨hal-02485022⟩
  • Leonie Baginski, Frédéric Tewes, Stephen Buckley, Anne Marie Healy, Udo Bakowsky, et al.. Investigations into the Fate of Inhaled Salmon Calcitonin at the Respiratory Epithelial Barrier. Pharmaceutical Research, American Association of Pharmaceutical Scientists, 2012, 29 (1), pp.332-341. ⟨10.1007/s11095-011-0553-z⟩. ⟨hal-02474502⟩
  • Frédéric Tewes, Oliviero Gobbo, Maria Amaro, Lidia Tajber, Owen Corrigan, et al.. Evaluation of HPβCD–PEG Microparticles for Salmon Calcitonin Administration via Pulmonary Delivery. Molecular Pharmaceutics, American Chemical Society, 2011, 8 (5), pp.1887-1898. ⟨10.1021/mp200231c⟩. ⟨hal-02472878⟩
  • Frédéric Tewes, Marie Pierre Krafft, Frank Boury. Dynamical and Rheological Properties of Fluorinated Surfactant Films Adsorbed at the Pressurized CO 2 –H 2 O Interface. Langmuir, American Chemical Society, 2011, 27 (13), pp.8144-8152. ⟨10.1021/la201009z⟩. ⟨hal-02472902⟩
  • Frederic Tewes, Julien Brillault, William Couet, Jean-Christophe Olivier. Formulation of rifampicin–cyclodextrin complexes for lung nebulization. Journal of Controlled Release, Elsevier, 2008, 129, pp.93 - 99. ⟨10.1016/j.jconrel.2008.04.007⟩. ⟨inserm-01102812⟩
  • Emilie Munnier, Frédéric Tewes, Simone Cohen-Jonathan, Claude Linassier, Laurence Douziech-Eyrolles, et al.. On the interaction of doxorubicin with oleate ions: fluorescence spectroscopy and liquid-liquid extraction study.. Chemical and Pharmaceutical Bulletin, Pharmaceutical Society of Japan, 2007, 55 (7), pp.1006-10. ⟨10.1248/cpb.55.1006⟩. ⟨inserm-00264631⟩
  • Frédéric Tewes, Emilie Munnier, B. Antoon, L. Ngaboni Okassa, Simone Cohen-Jonathan, et al.. Comparative study of doxorubicin-loaded poly(lactide-co-glycolide) nanoparticles prepared by single and double emulsion methods.. European Journal of Pharmaceutics and Biopharmaceutics, Elsevier, 2007, 66 (3), pp.488-92. ⟨10.1016/j.ejpb.2007.02.016⟩. ⟨inserm-00264615⟩
  • Emilie Munnier, Frédéric Tewes, Simone Cohen-Jonathan, Claude Linassier, Laurence Douziech-Eyrolles, et al.. On the Interaction of Doxorubicin with Oleate Ions: Fluorescence Spectroscopy and Liquid–Liquid Extraction Study. Chemical and Pharmaceutical Bulletin, Pharmaceutical Society of Japan, 2007, 55 (7), pp.1006-1010. ⟨10.1248/cpb.55.1006⟩. ⟨hal-02485040⟩
  • Frédéric Tewes, Frank Boury. Dynamic and rheological properties of classic and macromolecular surfactant at the supercritical CO2-H2O interface. Journal of Supercritical Fluids, Elsevier, 2006, 37 (3), pp.375-383. ⟨10.1016/j.supflu.2006.02.005⟩. ⟨inserm-00264738⟩
  • Frédéric Tewes, Frank Boury. Dynamic and rheological properties of classic and macromolecular surfactant at the supercritical CO2–H2O interface. Journal of Supercritical Fluids, Elsevier, 2006, 37 (3), pp.375-383. ⟨10.1016/j.supflu.2006.02.005⟩. ⟨hal-02485042⟩
  • Frédéric Tewes, Frank Boury. Formation and rheological properties of the supercritical CO2-water pure interface.. Journal of Physical Chemistry B, American Chemical Society, 2005, 109 (9), pp.3990-7. ⟨10.1021/jp046019w⟩. ⟨inserm-00264721⟩
  • Frédéric Tewes, Frank Boury. Formation and Rheological Properties of the Supercritical CO 2 −Water Pure Interface. Journal of Physical Chemistry B, American Chemical Society, 2005, 109 (9), pp.3990-3997. ⟨10.1021/jp046019w⟩. ⟨hal-02485043⟩
  • Frédéric Tewes, Frank Boury. Effect of H(2)O-CO(2) organization on ovalbumin adsorption at the supercritical CO(2)-water interface.. Journal of Physical Chemistry B, American Chemical Society, 2005, 109 (5), pp.1874-81. ⟨10.1021/jp046940d⟩. ⟨inserm-00264601⟩
  • Frédéric Tewes, Frank Boury. Effect of H 2 O−CO 2 Organization on Ovalbumin Adsorption at the Supercritical CO 2 −Water Interface. Journal of Physical Chemistry B, American Chemical Society, 2005, 109 (5), pp.1874-1881. ⟨10.1021/jp046940d⟩. ⟨hal-02485044⟩
  • Frédéric Tewes, Frank Boury. Thermodynamic and dynamic interfacial properties of binary carbon dioxide-water systems. Journal of Physical Chemistry B, American Chemical Society, 2004, 108 (7), pp.2405-2412. ⟨10.1021/jp030895c⟩. ⟨inserm-00264730⟩
  • Frédéric Tewes, Frank Boury. Thermodynamic and Dynamic Interfacial Properties of Binary Carbon Dioxide−Water Systems. Journal of Physical Chemistry B, American Chemical Society, 2004, 108 (7), pp.2405-2412. ⟨10.1021/jp030895c⟩. ⟨hal-02485045⟩
  • Hugh D.C. Smyth, Tania Bahamondez-Canas, Frederic Tewes, Lara Ashley Heersema. Antibiofilm formulations and use thereof. United States, Patent n° : WO2019104213A1. 2018. ⟨hal-02490735⟩
  • Frédéric Tewes, Julien Brillault, Hugh D.C. Smyth. Inhalable microparticles loaded with a fluoroquinolone/metal cation complex for the treatment of respiratory diseases. France, Patent n° : WO2018104759A1. 2018. ⟨hal-02485017⟩
  • Frank Boury, Jean-Pierre Benoit, Olivier Thomas, Frédéric Tewes. Method for preparing particles from an emulsion in supercritical or liquid CO2. France, Patent n° : US12/158,492. 2005. ⟨hal-02490765⟩
  • Frédéric Tewes, O.I. Corrigan, Anne Marie Healy. Surfactants in Pharmaceutical Products and Systems. Encyclopedia of Pharmaceutical Science and Technology, Six Volume, 2013. ⟨hal-02490781⟩
  • Frédéric Tewes, Frank Boury, Jean-Pierre Benoit. Biodegradable microspheres: Advances in production technology. Microencapsulation: Methods and Industrial Applications, Second Edition, 2005. ⟨hal-02490782⟩

Dr. Frédéric Tewes is an associate professor at the University of Poitiers and is affiliated with the INSERM U1070 research unit « Pharmacology of antimicrobial agents » since 2005. He is (co-)author of 35 articles, 4 patents, and 2 book chapters. His research activities focus on antimicrobial delivery, formulation science, inhalation and development of in vitro and in vivo infectious models. Through his 4-year post-doc position in Anne Marie Healy’s laboratory at Trinity College Dublin, he has acquired a good expertise in the field of spray-dried powders for inhalation and solid-state characterization. In 2016, he spent 7 months at the Smyth Lab at the University of Texas at Austin as a visiting professor, where he expanded his research on Pseudomonas aeruginosa lung biofilms, evaluation of in vivo models of chronic lung infection using an IVIS system, and animal dosing using a nose-only inhalation system. He has received funding from various agencies to progress his research (Euroregion grant, the French National Research Agency (ANR)). 

 

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