• Associate Professor in Biopharmacy
  • INSERM U1070 "Pharmacology of anti-infective agents"
    Pôle Biologie Santé
    1 rue Georges Bonnet
    86022 Poitiers cedex
    France
  • (33) 5 49 36 49 29
  • Research area: Pharmaceutics – pharmaceutical technology

    Key words: Drug delivery – inhalation – aerosol- microparticle – nanoparticle

Publications HAL

  • Rana Awad, Sandrine Marchand, William Couet, Mohamad Nasser, Julien Buyck, et al.. Assessment of inhaled cationic antibiotics in an in vitro model of Pseudomonas aeruginosa lung biofilm. Microbial Pathogenesis, 2024, 197, pp.107020. ⟨10.1016/j.micpath.2024.107020⟩. ⟨hal-04807257⟩
  • Carla Faivre, Farras Daffa Imtiyaz, Julien Buyck, Sandrine Marchand, Melissa Marcotte, et al.. (E, E)-farnesol and myristic acid-loaded lipid nanoparticles overcome colistin resistance in Acinetobacter baumannii. International Journal of Pharmaceutics, 2024, 667 (A), pp.124907. ⟨10.1016/j.ijpharm.2024.124907⟩. ⟨hal-04766832⟩
  • Jérémy Moreau, Thierry Noël, Kévin Point, Frederic Tewes, Luc Deroche, et al.. Pan-azole-resistant Meyerozyma guilliermondii clonal isolates harbouring a double F126L and L505F mutation in Erg11.. Mycoses, 2024, 67 (3), pp.e13704. ⟨10.1111/myc.13704⟩. ⟨hal-04715648⟩
  • Guillaume Hamion, Willy Aucher, Anne Mercier, Frederic Tewes, Maëlenn Menard, et al.. Insights into betulinic acid as a promising molecule to fight the interkingdom biofilm Staphylococcus aureus-Candida albicans. International Journal of Antimicrobial Agents, 2024, 63 (6), pp.107166. ⟨10.1016/j.ijantimicag.2024.107166⟩. ⟨hal-04542854⟩
  • Frederic Tewes, Barbara Lamy, Julian Laroche, Isabelle Lamarche, Sandrine Marchand. PK-PD Evaluation of Inhaled Microparticles loaded with Ciprofloxacin-Copper complex in a Rat Model of Chronic Pseudomonas aeruginosa Lung Infection.. International Journal of Pharmaceutics: X, 2023, 5, pp.100178. ⟨10.1016/j.ijpx.2023.100178⟩. ⟨hal-04104592⟩
  • Guillermo Landa, Laura Miranda-Calderon, Alex Gomez, Marta Perez, Victor Sebastian, et al.. Real-time in vivo monitoring of the antimicrobial action of combination therapies in the management of infected topical wounds. International Journal of Pharmaceutics, 2023, 646, pp.123502. ⟨10.1016/j.ijpharm.2023.123502⟩. ⟨hal-04473922⟩
  • Guillermo Landa, Teresa Alejo, Theo Sauzet, Julian Laroche, Victor Sebastian, et al.. Colistin-loaded aerosolizable particles for the treatment of bacterial respiratory infections. International Journal of Pharmaceutics, 2023, 635, pp.122732. ⟨10.1016/j.ijpharm.2023.122732⟩. ⟨hal-04088066⟩
  • E. de Pablo, P. O'Connell, R. Fernández-García, S. Marchand, A. Chauzy, et al.. Targeting lung macrophages for fungal and parasitic pulmonary infections with innovative amphotericin B dry powder inhalers. International Journal of Pharmaceutics, 2023, 635, pp.122788. ⟨10.1016/j.ijpharm.2023.122788⟩. ⟨hal-04131635⟩
  • Kévin Brunet, Jean-Philippe Martellosio, Frederic Tewes, Sandrine Marchand, Blandine Rammaert. Inhaled Antifungal Agents for Treatment and Prophylaxis of Bronchopulmonary Invasive Mold Infections. Pharmaceutics, 2022, 14 (3), pp.641. ⟨10.3390/pharmaceutics14030641⟩. ⟨hal-03626610⟩
  • Kévin Brunet, Cheikh Diop, Alexia Chauzy, Noémie Prébonnaud, Sandrine Marchand, et al.. Improved In Vitro Anti-Mucorales Activity and Cytotoxicity of Amphotericin B with a Pegylated Surfactant. Journal of Fungi, 2022, 8 (2), pp.121. ⟨10.3390/jof8020121⟩. ⟨hal-03615762⟩
  • Chantal Valcourt, Julien Buyck, Nicolas Grégoire, William Couet, Sandrine Marchand, et al.. Lipid Nanoparticles Loaded with Farnesol or Geraniol to Enhance the Susceptibility of E. coli MCR-1 to Colistin. Pharmaceutics, 2021, 13 (11), pp.1849. ⟨10.3390/pharmaceutics13111849⟩. ⟨hal-03626643⟩
  • Frederic Tewes, Tania F Bahamondez-Canas, Daniel Moraga-Espinoza, Hugh D C Smyth, Alan B Watts. In vivo Efficacy of a Dry Powder Formulation of Ciprofloxacin-Copper Complex in a Chronic Lung Infection Model of Bioluminescent Pseudomonas aeruginosa. European Journal of Pharmaceutics and Biopharmaceutics, 2020, 152, pp.201-217. ⟨10.1016/j.ejpb.2020.05.014⟩. ⟨inserm-02615177⟩
  • Julien Brillault, Frederic Tewes. Control of the Lung Residence Time of Highly Permeable Molecules after Nebulization: Example of the Fluoroquinolones. Pharmaceutics, 2020, 12 (4), pp.E387. ⟨10.3390/pharmaceutics12040387⟩. ⟨inserm-02558855⟩
  • Frederic Tewes, Julien Brillault, Nicolas Grégoire, Jean-Christophe Olivier, Isabelle Lamarche, et al.. Comparison between Colistin Sulfate Dry Powder and Solution for Pulmonary Delivery. Pharmaceutics, 2020, 12 (6), pp.557. ⟨10.3390/pharmaceutics12060557⟩. ⟨hal-02875013⟩
  • Bruna Gaelzer Silva Torres, Rana Awad, Sandrine Marchand, William Couet, Frédéric Tewes. In vitro evaluation of Pseudomonas aeruginosa chronic lung infection models: Are agar and calcium-alginate beads interchangeable?. European Journal of Pharmaceutics and Biopharmaceutics, 2019, 143, pp.35-43. ⟨10.1016/j.ejpb.2019.08.006⟩. ⟨hal-02477575⟩
  • Siti Nani Nurbaeti, Julien Brillault, Frédéric Tewes, Jean-Christophe Olivier. Sustained-release microparticle dry powders of chloramphenicol palmitate or thiamphenicol palmitate prodrugs for lung delivery as aerosols. European Journal of Pharmaceutical Sciences, 2019, 138, pp.105028. ⟨10.1016/j.ejps.2019.105028⟩. ⟨hal-02477590⟩
  • Frédéric Tewes, Tania F Bahamondez-Canas, Hugh D C Smyth. Efficacy of Ciprofloxacin and Its Copper Complex against Pseudomonas aeruginosa Biofilms. AAPS PharmSciTech, 2019, 20 (5), pp.205. ⟨10.1208/s12249-019-1417-9⟩. ⟨hal-02477817⟩
  • Barbara Lamy, Dolores Remedios Serrano, Peter O’connell, William Couet, Sandrine Marchand, et al.. Use of leucine to improve aerodynamic properties of ciprofloxacin-loaded maltose microparticles for inhalation. European Journal of Pharmaceutical Research, 2019, 1 (1), pp.2-11. ⟨10.34154/2019-EJPR.01(01).pp-02-11/euraass⟩. ⟨hal-02493122⟩
  • Tania F Bahamondez-Canas, Hairui Zhang, Frederic Tewes, Jasmim Leal, Hugh D C Smyth. PEGylation of Tobramycin Improves Mucus Penetration and Antimicrobial Activity against Pseudomonas aeruginosa Biofilms in Vitro. Molecular Pharmaceutics, 2018, 15 (4), pp.1643-1652. ⟨10.1021/acs.molpharmaceut.8b00011⟩. ⟨inserm-02379306⟩
  • Barbara Lamy, Dolores Remedios Serrano, Isabelle Lamarche, Patrice Gobin, William Couet, et al.. New aerosol formulation to control ciprofloxacin pulmonary concentration. Journal of Controlled Release, 2017, 271, pp.118-126. ⟨10.1016/j.jconrel.2017.12.021⟩. ⟨inserm-02379277⟩
  • Julien Brillault, Frédéric Tewes, William Couet, Jean-Christophe Olivier. In vitro biopharmaceutical evaluation of ciprofloxacin/metal cation complexes for pulmonary administration.. European Journal of Pharmaceutical Sciences, 2017, 97, pp.92-98. ⟨10.1016/j.ejps.2016.11.011⟩. ⟨inserm-01416565⟩
  • Frederic Tewes, Oliviero L Gobbo, Carsten Ehrhardt, Anne Marie Healy. Amorphous calcium carbonate based-microparticles for peptide pulmonary delivery. ACS Applied Materials & Interfaces, 2015, 8 (2), pp.1164-1175. ⟨10.1021/acsami.5b09023⟩. ⟨inserm-01375596⟩
  • Frédéric Tewes, Oliviero L Gobbo, Carsten Ehrhardt, Anne Marie Healy. Amorphous Calcium Carbonate Based-Microparticles for Peptide Pulmonary Delivery. ACS Applied Materials & Interfaces, 2015, 2016, 8 (2), pp.1164-1175. ⟨10.1021/acsami.5b09023⟩. ⟨hal-02484982⟩
  • Frederic Tewes, Julien Brillault, Barbara Lamy, Peter O 'Connell, Jean-Christophe Olivier, et al.. Ciprofloxacin-Loaded Inorganic–Organic Composite Microparticles To Treat Bacterial Lung Infection. Molecular Pharmaceutics, 2015, 13 ((1)), pp.100-112. ⟨10.1021/acs.molpharmaceut.5b00543⟩. ⟨inserm-01373710⟩
  • Marisa Gaspar, João J.S. Sousa, Alberto A.C.C. Pais, Olga Cardoso, Dina Murtinho, et al.. Optimization of levofloxacin-loaded crosslinked chitosan microspheres for inhaled aerosol therapy. European Journal of Pharmaceutics and Biopharmaceutics, 2015, 96, pp.65-75. ⟨10.1016/j.ejpb.2015.07.010⟩. ⟨hal-02478056⟩
  • Maria Inês Amaro, Frédéric Tewes, Oliviero L Gobbo, Lidia Tajber, Owen I Corrigan, et al.. Formulation, stability and pharmacokinetics of sugar-based salmon calcitonin-loaded nanoporous/nanoparticulate microparticles (NPMPs) for inhalation. International Journal of Pharmaceutics, 2015, 483 (1-2), pp.6-18. ⟨10.1016/j.ijpharm.2015.02.003⟩. ⟨hal-02484990⟩
  • Ahmad S Barham, Frédéric Tewes, Anne Marie Healy. Moisture diffusion and permeability characteristics of hydroxypropylmethylcellulose and hard gelatin capsules. International Journal of Pharmaceutics, 2015, 478 (2), pp.796-803. ⟨10.1016/j.ijpharm.2014.12.029⟩. ⟨inserm-02379337⟩
  • M.-K. Tran, L.N. Hassani, B. Calvignac, Thomas Beuvier, Frédéric Tewes, et al.. Corrigendum to “Lysozyme encapsulation within PLGA and CaCO3 microparticles using supercritical CO2 medium” [J. Supercrit. Fluids 79 (2013) 159–169]. Journal of Supercritical Fluids, 2014, 88, pp.142. ⟨10.1016/j.supflu.2014.02.018⟩. ⟨hal-02484969⟩
  • Janani Swaminathan, Oliviero L Gobbo, Frédéric Tewes, Anne Marie Healy, Carsten Ehrhardt. Encapsulation into PEG-Liposomes Does Not Improve the Bioavailability of Pulmonary Delivered Salmon Calcitonin. JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 2014, 27 (1), pp.1-11. ⟨10.1089/jamp.2013.1049⟩. ⟨hal-02484995⟩
  • Frederic Tewes, Carsten Ehrhardt, Anne Marie Healy. Superparamagnetic iron oxide nanoparticles (SPIONs)-loaded Trojan microparticles for targeted aerosol delivery to the lung. European Journal of Pharmaceutics and Biopharmaceutics, 2014, 86, pp.98 - 104. ⟨10.1016/j.ejpb.2013.09.004⟩. ⟨inserm-01102561⟩
  • Frederic Tewes, Krzysztof J. Paluch, Lidia Tajber, Karan Gulati, Devesh Kalantri, et al.. Steroid/mucokinetic hybrid nanoporous microparticles for pulmonary drug delivery. European Journal of Pharmaceutics and Biopharmaceutics, 2013, 85 (3), pp.604-613. ⟨10.1016/j.ejpb.2013.03.020⟩. ⟨inserm-01102852⟩
  • Stefano Bianco, Frederic Tewes, Lidia Tajber, Vincent Caron, Owen I. Corrigan, et al.. Bulk, surface properties and water uptake mechanisms of salt/acid amorphous composite systems. International Journal of Pharmaceutics, 2013, 456 (1), pp.143-152. ⟨10.1016/j.ijpharm.2013.07.076⟩. ⟨inserm-01102838⟩
  • Oliviero L Gobbo, Magdalena Zurek, Frédéric Tewes, Carsten Ehrhardt, Yannick Crémillieux. Manganese: a new contrast agent for lung imaging?. Contrast Media and Molecular Imaging, 2012, 7 (6), pp.542-546. ⟨10.1002/cmmi.1483⟩. ⟨hal-02485025⟩
  • Leonie Baginski, Oliviero L Gobbo, Frédéric Tewes, Johanna Salomon, Anne Marie Healy, et al.. In Vitro and In Vivo Characterisation of PEG-Lipid-Based Micellar Complexes of Salmon Calcitonin for Pulmonary Delivery. Pharmaceutical Research, 2012, 29 (6), pp.1425-1434. ⟨10.1007/s11095-012-0688-6⟩. ⟨hal-02485022⟩
  • Leonie Baginski, Frédéric Tewes, Stephen Buckley, Anne Marie Healy, Udo Bakowsky, et al.. Investigations into the Fate of Inhaled Salmon Calcitonin at the Respiratory Epithelial Barrier. Pharmaceutical Research, 2012, 29 (1), pp.332-341. ⟨10.1007/s11095-011-0553-z⟩. ⟨hal-02474502⟩
  • Frédéric Tewes, Oliviero L Gobbo, Maria Amaro, Lidia Tajber, Owen I Corrigan, et al.. Evaluation of HPβCD–PEG Microparticles for Salmon Calcitonin Administration via Pulmonary Delivery. Molecular Pharmaceutics, 2011, 8 (5), pp.1887-1898. ⟨10.1021/mp200231c⟩. ⟨hal-02472878⟩
  • Frédéric Tewes, Marie Pierre Krafft, Frank Boury. Dynamical and Rheological Properties of Fluorinated Surfactant Films Adsorbed at the Pressurized CO 2 –H 2 O Interface. Langmuir, 2011, 27 (13), pp.8144-8152. ⟨10.1021/la201009z⟩. ⟨hal-02472902⟩
  • Frédéric Tewes, Lidia Tajber, Owen I Corrigan, Carsten Ehrhardt, Anne-Marie Healy. Development and characterisation of soluble polymeric particles for pulmonary peptide delivery. European Journal of Pharmaceutical Sciences, 2010, 41 (2), pp.337-352. ⟨10.1016/j.ejps.2010.07.001⟩. ⟨inserm-01102826⟩
  • F. Tewes, L. Tajber, O.I. Corrigan, C. Ehrhardt, A.M. Healy. Development and characterisation of soluble polymeric particles for pulmonary peptide delivery. European Journal of Pharmaceutical Sciences, 2010, 41 (2), pp.337-352. ⟨10.1016/j.ejps.2010.07.001⟩. ⟨hal-02485033⟩
  • Frederic Tewes, Julien Brillault, William Couet, Jean-Christophe Olivier. Formulation of rifampicin–cyclodextrin complexes for lung nebulization. Journal of Controlled Release, 2008, 129, pp.93 - 99. ⟨10.1016/j.jconrel.2008.04.007⟩. ⟨inserm-01102812⟩
  • Emilie Munnier, Frédéric Tewes, Simone Cohen-Jonathan, Claude Linassier, Laurence Douziech-Eyrolles, et al.. On the interaction of doxorubicin with oleate ions: fluorescence spectroscopy and liquid-liquid extraction study.. Chemical and Pharmaceutical Bulletin, 2007, 55 (7), pp.1006-10. ⟨10.1248/cpb.55.1006⟩. ⟨inserm-00264631⟩
  • F. Tewes, E. Munnier, B. Antoon, L. Ngaboni Okassa, S. Cohen-Jonathan, et al.. Comparative study of doxorubicin-loaded poly(lactide-co-glycolide) nanoparticles prepared by single and double emulsion methods. European Journal of Pharmaceutics and Biopharmaceutics, 2007, 66 (3), pp.488-492. ⟨10.1016/j.ejpb.2007.02.016⟩. ⟨hal-02485037⟩
  • Frédéric Tewes, Emilie Munnier, B. Antoon, L. Ngaboni Okassa, Simone Cohen-Jonathan, et al.. Comparative study of doxorubicin-loaded poly(lactide-co-glycolide) nanoparticles prepared by single and double emulsion methods.. European Journal of Pharmaceutics and Biopharmaceutics, 2007, 66 (3), pp.488-92. ⟨10.1016/j.ejpb.2007.02.016⟩. ⟨inserm-00264615⟩
  • Emilie Munnier, Frédéric Tewes, Simone Cohen-Jonathan, Claude Linassier, Laurence Douziech-Eyrolles, et al.. On the Interaction of Doxorubicin with Oleate Ions: Fluorescence Spectroscopy and Liquid–Liquid Extraction Study. Chemical and Pharmaceutical Bulletin, 2007, 55 (7), pp.1006-1010. ⟨10.1248/cpb.55.1006⟩. ⟨hal-02485040⟩
  • Frédéric Tewes, Frank Boury. Dynamic and rheological properties of classic and macromolecular surfactant at the supercritical CO2-H2O interface. Journal of Supercritical Fluids, 2006, 37 (3), pp.375-383. ⟨10.1016/j.supflu.2006.02.005⟩. ⟨inserm-00264738⟩
  • Frédéric Tewes, Frank Boury. Formation and rheological properties of the supercritical CO2-water pure interface.. Journal of Physical Chemistry B, 2005, 109 (9), pp.3990-7. ⟨10.1021/jp046019w⟩. ⟨inserm-00264721⟩
  • Frédéric Tewes, Frank Boury. Effect of H(2)O-CO(2) organization on ovalbumin adsorption at the supercritical CO(2)-water interface.. Journal of Physical Chemistry B, 2005, 109 (5), pp.1874-81. ⟨10.1021/jp046940d⟩. ⟨inserm-00264601⟩
  • Frédéric Tewes, Frank Boury. Thermodynamic and dynamic interfacial properties of binary carbon dioxide-water systems. Journal of Physical Chemistry B, 2004, 108 (7), pp.2405-2412. ⟨10.1021/jp030895c⟩. ⟨inserm-00264730⟩
  • Kévin Brunet, Jonathan Clarhaut, Adrien Baillod, Sandrine Marchand, Frederic Tewes. Enhancement of amphotericin B activity against Cryptococcus neoformans using lipid nanoparticles. 33rd ECCMID : European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenaghen, Denmark. ⟨hal-04142666⟩
  • Hugh D.C. Smyth, Tania F Bahamondez-Canas, Frederic Tewes, Lara Ashley Heersema. Antibiofilm formulations and use thereof. United States, Patent n° : WO2019104213A1. 2018. ⟨hal-02490735⟩
  • Frédéric Tewes, Julien Brillault, Hugh D.C. Smyth. Inhalable microparticles loaded with a fluoroquinolone/metal cation complex for the treatment of respiratory diseases. France, Patent n° : WO2018104759A1. 2018. ⟨hal-02485017⟩
  • Frank Boury, Jean-Pierre Benoit, Olivier Thomas, Frédéric Tewes. Method for preparing particles from an emulsion in supercritical or liquid CO2. France, Patent n° : US12/158,492. 2005. ⟨hal-02490765⟩
  • Frédéric Tewes, O.I. Corrigan, Anne Marie Healy. Surfactants in Pharmaceutical Products and Systems. Encyclopedia of Pharmaceutical Science and Technology, Six Volume, 2013. ⟨hal-02490781⟩
  • Frédéric Tewes, Frank Boury, Jean-Pierre Benoit. Biodegradable microspheres: Advances in production technology. Microencapsulation: Methods and Industrial Applications, Second Edition, 2005. ⟨hal-02490782⟩
  • Frederic Tewes, Gobbo Ol, Lidia Tajber, Owen I Corrigan, Carsten Ehrhardt, et al.. sCT loaded HPbCD/PEG particles : Physicochemical properties and sCT pharmacokinetics after pulmonary delivery. AAPS 2010, 2010, New Orleans, United States. ⟨inserm-01103116⟩

Dr. Frédéric Tewes is an associate professor at the University of Poitiers and is affiliated with the INSERM U1070 research unit « Pharmacology of antimicrobial agents » since 2005.

He is (co-)author of 35 articles, 4 patents, and 2 book chapters. His research activities focus on antimicrobial delivery, formulation science, inhalation and development of in vitro and in vivo infectious models. Through his 4-year post-doc position in Anne Marie Healy’s laboratory at Trinity College Dublin, he has acquired a good expertise in the field of spray-dried powders for inhalation and solid-state characterization. In 2016, he spent 7 months at the Smyth Lab at the University of Texas at Austin as a visiting professor, where he expanded his research on Pseudomonas aeruginosa lung biofilms, evaluation of in vivo models of chronic lung infection using an IVIS system, and animal dosing using a nose-only inhalation system.

He has received funding from various agencies to progress his research (Euroregion grant, the French National Research Agency (ANR)). 

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