Christophe Adier

  • Christophe Adier
Fil d'ariane
    • Engineer in Analytical Chemistry and Quality Control
    • Responsible for Quality
    • INSERM U1070 "Pharmacology of anti-infective agents"
      Pôle Biologie Santé
      1 rue Georges Bonnet
      86022 Poitiers cedex
      France
    • +33 (0)5 49 45 49 69

    Publications HAL

    Article dans une revue (12 documents)
    • Noémie Prébonnaud, Alexia Chauzy, Nicolas Grégoire, Claire Dahyot-Fizelier, Christophe Adier, et al.. A freely accessible, adaptable hollow-fiber setup to reproduce first-order absorption: illustration with linezolid cerebrospinal fluid pharmacokinetic data. Microbiology Spectrum, 2025, ⟨10.1128/spectrum.00051-25⟩. ⟨hal-05085650⟩
    • Alexia Chauzy, Salim Bouchène, Vincent Aranzana-Climent, Jonathan Clarhaut, Christophe Adier, et al.. A Minimal Physiologically Based Pharmacokinetic Model to Characterize CNS Distribution of Metronidazole in Neuro Care ICU Patients. Antibiotics, 2022, 11 (10), pp.1293. ⟨10.3390/antibiotics11101293⟩. ⟨hal-03906712⟩
    • Frederic Tewes, Julien Brillault, Nicolas Grégoire, Jean-Christophe Olivier, Isabelle Lamarche, et al.. Comparison between Colistin Sulfate Dry Powder and Solution for Pulmonary Delivery. Pharmaceutics, 2020, 12 (6), pp.557. ⟨10.3390/pharmaceutics12060557⟩. ⟨hal-02875013⟩
    • Alexia Chauzy, Bruna Gaelzer Silva Torres, Julien Buyck, Boudewijn Jonge, Christophe Adier, et al.. Semimechanistic Pharmacodynamic Modeling of Aztreonam‐Avibactam Combination to Understand Its Antimicrobial Activity Against Multidrug‐Resistant Gram‐Negative Bacteria. CPT: Pharmacometrics and Systems Pharmacology, 2019, ⟨10.1002/psp4.12452⟩. ⟨hal-02320523⟩
    • Sandrine Marchand, Matthieu Boisson, Shachi Mehta, Christophe Adier, Olivier Mimoz, et al.. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 6. Aminoglycosides. Antimicrobial Agents and Chemotherapy, 2018, 62 (10), ⟨10.1128/AAC.01261-18⟩. ⟨hal-02481204⟩
    • Alexia Chauzy, Isabelle Lamarche, Christophe Adier, William Couet, Sandrine Marchand. Microdialysis Study of Aztreonam-Avibactam Distribution in Peritoneal Fluid and Muscle of Rats with or without Experimental Peritonitis. Antimicrobial Agents and Chemotherapy, 2018, 62 (10), ⟨10.1128/AAC.01228-18⟩. ⟨hal-02321070⟩
    • Matthieu Boisson, Olivier Mimoz, Mirza Hadzic, Sandrine Marchand, Christophe Adier, et al.. Pharmacokinetics of intravenous and nebulized gentamicin in critically ill patients. Journal of Antimicrobial Chemotherapy, 2018, 73 (10), pp.2830-2837. ⟨10.1093/jac/dky239⟩. ⟨hal-02481185⟩
    • Siti Nurbaeti, Jean-Christophe Olivier, Christophe Adier, Sandrine Marchand, William Couet, et al.. Active Mediated Transport of Chloramphenicol and Thiamphenicol in a Calu-3 Lung Epithelial Cell Model. Journal of Pharmaceutical Sciences, 2018, 107 (4), pp.1178-1184. ⟨10.1016/j.xphs.2017.11.021⟩. ⟨hal-02481308⟩
    • Denis Frasca, Claire Dahyot-Fizelier, Christophe Adier, Olivier Mimoz, Bertrand Debaene, et al.. Metronidazole and Hydroxymetronidazole Central Nervous System Distribution: 2. Cerebrospinal Fluid Concentration Measurements in Patients with External Ventricular Drain. Antimicrobial Agents and Chemotherapy, 2014, 58 (2), pp.1024-1027. ⟨10.1128/AAC.01762-13⟩. ⟨hal-02477611⟩
    • Denis Frasca, Claire Dahyot-Fizelier, Christophe Adier, Olivier Mimoz, Bertrand Debaene, et al.. Metronidazole and Hydroxymetronidazole Central Nervous System Distribution: 1. Microdialysis Assessment of Brain Extracellular Fluid Concentrations in Patients with Acute Brain Injury. Antimicrobial Agents and Chemotherapy, 2014, 58 (2), pp.1019-1023. ⟨10.1128/AAC.01760-13⟩. ⟨hal-02477606⟩
    • Claire Dahyot-Fizelier, Denis Frasca, Nicolas Grégoire, Christophe Adier, Olivier Mimoz, et al.. Microdialysis Study of Cefotaxime Cerebral Distribution in Patients with Acute Brain Injury. Antimicrobial Agents and Chemotherapy, 2013, 57 (6), pp.2738-2742. ⟨10.1128/AAC.02570-12⟩. ⟨hal-02474273⟩
    • Oudy Semoun, Sandrine Marchand, Nicolas Grégoire, Isabelle Lamarche, Christophe Adier, et al.. Modeling Approach To Characterize Intraocular Doripenem Pharmacokinetics after Intravenous Administration to Rabbits, with Tentative Extrapolation to Humans. Antimicrobial Agents and Chemotherapy, 2012, 56 (7), pp.3531-3534. ⟨10.1128/AAC.06329-11⟩. ⟨hal-02474348⟩
    Pré-publication, Document de travail (1 document)
    • Noémie Prébonnaud, Alexia Chauzy, Nicolas Grégoire, Claire Dahyot-Fizelier, Christophe Adier, et al.. A freely accessible, adaptable hollow-fiber setup to reproduce first-order absorption: illustration with linezolid cerebrospinal fluid pharmacokinetic data. 2025. ⟨hal-05030769⟩
    Poster (2 documents)
    • Noémie Prébonnaud, Alexia Chauzy, Christophe Adier, Isabelle Martin, Claire Dahyot-Fizelier, et al.. Impact of in vitro use of artificial cerebrospinal fluid compared to Mueller-Hinton broth on the efficacy of linezolid against Staphylococcus aureus in a hollow-fiber model. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain. ⟨hal-04571091⟩
    • Alexia Chauzy, Bruna Gaelzer Silva Torres, Julien Buyck, Boudewijn Jonge, Christophe Adier, et al.. Semi-mechanistic pharmacodynamics modeling of aztreonam- avibactam combination to understand its antimicrobial activity against multidrug-resistant Gram(-) bacteria. PAGE meeting, Jun 2019, Stockholm, Sweden. ⟨hal-02528382⟩

    Short CV:

    Graduated in 1998, Christophe ADIER (born 11.091971, France) started his career by short experiences (2 years in Namibia, 1 year in Clermont-Ferrand) in the field of vegetal biology.

    After a 5 years’ experience as a Research and Development Engineer for formulation development of active substances based on cyclodextrin technology (SAS BIOCYDEX, France), he joined the INSERM U1070 unit as an Engineer of the CHU of Poitiers in 2009 to work on development and validation of analytical methods in order to optimize antibiotics dosages in various biological matrixes. He is also in charge with the quality politic of the unit through ISO 9001 certification and follow up.

    Technical skills:

    Analytic: Development, validation and routine use of dosage methods for various antibiotics in different matrixes (blood, urines, CSF, BAL, tissues, etc.) and different species (mouse, rat, human, etc.) by HPLC or LC-MS/MS.

    Quality: establishment of quality criteria, development of evaluation tools, and implementation of Quality Assurance System in order to comply with ISO requirements and to obtain ISO 9001 certification.

    Research Area: Analytic: HPLC, LC-MS/MS, Quality according to ISO 9001.

     

    Main recent publications:

    • Find us on

    INSERM U1070

    UFR de Médecine et Pharmacie - Université de Poitiers - Pôle Biologie Santé - Bâtiment B36
    1 rue Georges Bonnet
    86022 POITIERS Cedex, France

    (33) (0)5 49 45 49 69
    (33) (0)5 49 45 43 78

    Envoyer un mail