Inserm U1070 presents a strong activity in analytics to measure drug concentrations in various biological fluids (plasma, urine, broncho-alveoalar lavage, sputum, feces, …).

Consequently, a platform was developed in the lab which is run according to quality management rules and is awarded ISO 9001 certification since January 2014 (ongoing renewal october 2020).

(ongoing renewal october 2020)

The platfrom is composed of 2 HPLC (High Performance Liquid Chromatography) with UV ans fluorescence detectors and 2 Liquid Chromatography coupled with mass spectometers in tandem (LC-MS/MS quattro Micro Api, Waters France and TQ 3500, Apllied Biosystems, France).

HPLC with UV and fluorescence detectors

 

Liquid Chromatography coupled with tandem mass spectometers

 

All samples are treated in an extraction room (MSW 137) which provides all materials necessary to perform samples extraction (solvent cabinet, chemical hood, 2 systems for solid-liquid extraction, …).

 

We are able to dose more than 50 molecules among different matrix (like plasma, urine, feces, LCR, LBA and tissue) and different species (human, murines, porc, cows, goat, rabbit and monkey)

Analytes are :

Antibiotics:
Aminoglycosides β-lactams Fluoroquinolones Macrolides Polymyxins
amikacin
gentamicin
kanamycin
tobramycin
ampicillin
amoxicilin
aztreonam
cefotaxime
cefoxitin
ceftaroline
ceftazidime
ceftolozane
ceftriaxone
doripenem
ertapenem
meropenem
piperacillin
imipenem
ciprofloxacin
grepafloxacin
levofloxacin
marbofloxacin
moxifloxacin
norfloxacin
pelfoxacin
clarithromycin
clindamycin
streptomycin
colistin
colistimethate sulfonate
polymyxin B
Tetracyclines Other antibiotics β-lactamases inhibitors  Antifungal drugs
Antiviral drugs
doxocycline
minocycline
oxytetracycline
tigecycline
chloramphenicol
daptomycine
ethambutol
hydroxymetronidazole
isoniazid
linezolid
metronidazole
pyrazinamide
rifampicin
sulfamethoxazole
tedizolid
thiamphénicol
trimethoprim
vancomycin
clavulanic acid
avibactam
amphotericin B
anidulafungin
caspofungin
micafungin
voriconazole
oseltamivir
Other drugs
antipyrin
bromazepam
caffeine
cyclosporin
dopamine
fluticazone propionate
imatinib
mitotane
nicotine
olanzapine
acetaminophen
simvastatin
sucrose
tacrolimus
urea
zosuquidar

 

 

 

 


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