📢 New Publication in Antimicrobial Agents and Chemotherapy!

We are thrilled to share our last article:

« PKPD modeling of the inoculum effect of combined ceftazidime/avibactam and colistin against KPC-3 Klebsiella pneumoniae« 
🔗 https://doi.org/10.1128/aac.01797-24

🔬 What’s new?
We used pharmacokinetic/pharmacodynamic (PKPD) modeling to explore how bacterial load influences the efficacy of the ceftazidime/avibactam + colistin combo—key agents against multidrug-resistant Klebsiella pneumoniae.

👨‍🔬 Key findings:

• The inoculum effect (IE) significantly reduced drug efficacy at high bacterial loads (10⁸ CFU/mL)

• CZA’s max killing effect (Emax) dropped with increasing inoculum

• CST required higher concentrations (↑ EC50) to maintain effect

• No synergistic modulation of the IE between drugs

💡 Takeaway:
Infections with high bacterial burden may limit the effectiveness of this antibiotic combo—highlighting the importance of integrating IE in treatment simulations.

Thanks to our amazing collaborators across Poitiers, Fribourg, Paris, Hamburg & beyond! 🙌
Funded by the ANR (Co-Protect project) 🇫🇷