📢 New Publication in Microbiology Spectrum!

We are delighted to present our latest article:
« A freely accessible, adaptable hollow-fiber setup to reproduce first-order absorption: illustration with linezolid cerebrospinal fluid pharmacokinetic data » 🔗

🔎 What’s new?

We developed and validated a novel hollow-fiber setup that enables in vitro simulation of mono-compartmental pharmacokinetics with an absorption phase, requiring only the addition of a programmable infusion pump to the traditional experimental setup.

✅ Key Result
We successfully replicated cerebrospinal fluid concentrations of linezolid observed in intensive care unit patients.

💡Why it matters ?

This tool supports optimization of antibiotic dosing regimens by accurately simulating:
• Drug concentrations at infection sites
• Plasma concentrations after oral or other extravascular administration

🔧 Try It Yourself
The algorithm and setup are available in an open-source web application to facilitate the design of hollow-fiber experimental protocols. 🔗 Click here!