Julien Buyck

  • Julien Buyck
Fil d'ariane
    • Associate Professor in Microbiology
    • INSERM U1070 "Pharmacology of anti-infective agents"
      Pôle Biologie Santé
      1 rue Georges Bonnet
      86022 Poitiers cedex
      France
    • +33 (0)5 49 45 49 28
    • Research area: Microbiology

      Key words: Gram-negative, antibiotic resistance, molecular biology

    Publications HAL

    Poster (9 documents)
    • Julie Charles, Jonathan Clarhaut, Laure Prouvensier, Tom Collet, Lucas Keomany, et al.. Assessment of in vitro efficacy of three-antibiotics combinations against Mycobacterium abscessus. ESCMID Global 2025, Apr 2025, Vienna, Austria. . ⟨hal-05071423⟩
    • Vincent Aranzana-Climent, Laure Prouvensier, Tom Collet, Sandrine Marchand, Nicolas Grégoire, et al.. Spotting method as a high throughput alternative to the conventional spread plating method. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain. ⟨hal-04575530⟩
    • Vincent Aranzana-Climent, Laure Prouvensier, Tom Collet, Sandrine Marchand, Nicolas Grégoire, et al.. Spotting method as a high throughput alternative to the conventional spread plating method conventional spread plating method for bacterial time kill experiments. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain. ⟨hal-04571076⟩
    • Zahyra Kaouah, Julien Buyck, Sandrine Marchand, Christophe Burucoa, Maxime Pichon, et al.. In vitro bactericidal activity of amoxicillin combined to clarithromycin or levofloxacin on clinical strains of Helicobacter pylori. 33rd ECCMID 2023: European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenaghen, Denmark. ⟨hal-04141293⟩
    • Victor Luzarraga, Maxime Pichon, Julie Cremniter, Sandrine Marchand, Julien Buyck, et al.. Validation by site-directed mutagenesis of mutations described as associated with clarithromycin resistance in Helicobacter pylori. 33rd ECCMID :: European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenaghen, Denmark. ⟨hal-04141398⟩
    • Zahyra Kaouah, Julien Buyck, Sandrine Marchand, Christophe Burucoa, Maxime Pichon, et al.. In vitro efficacy of antibiotics used in clinical practice on clinical isolates of Helicobacter pylori. 33rd ECCMID 2023: European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenhagen, Denmark. ⟨hal-04141313⟩
    • Mathilde Lacroix, Alexia Chauzy, Claudia Zampaloni, Caterina Bissantz, Hélène Mirfendereski, et al.. In vitro PK/PD modelling of polymyxin B against resistant strain of A. baumannii in presence of mucin. 32nd ECCMID, Apr 2022, Lisabon, Portugal. ⟨hal-04016532⟩
    • Alexia Chauzy, Bruna Gaelzer Silva Torres, Julien Buyck, Boudewijn Jonge, Christophe Adier, et al.. Semi-mechanistic pharmacodynamics modeling of aztreonam- avibactam combination to understand its antimicrobial activity against multidrug-resistant Gram(-) bacteria. PAGE meeting, Jun 2019, Stockholm, Sweden. ⟨hal-02528382⟩
    • Alexia Chauzy, Bruna Gaelzer Silva Torres, Julien Buyck, Emma Marquizeau, Patrice Gobin, et al.. Semi-mechanistic pharmacokinetic/pharmacodynamics modeling of aztreonam-avibactam combination against multidrug resistant Gram(-) organisms. the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2018, Madrid, Spain. ⟨hal-02528294⟩
    Article dans une revue (36 documents)
    • Luc Deroche, Albane Rozenholc, François Arrivé, Jean-Philippe Martellosio, Gwenael Le Moal, et al.. Emergence of cefiderocol resistance during therapy in NDM-5–producing Klebsiella pneumoniae isolates harboring siderophore receptors mutations. International Journal of Infectious Diseases, 2025, 151, pp.107321. ⟨10.1016/j.ijid.2024.107321⟩. ⟨hal-05023898⟩
    • Rana Awad, Sandrine Marchand, William Couet, Mohamad Nasser, Julien Buyck, et al.. Assessment of inhaled cationic antibiotics in an in vitro model of Pseudomonas aeruginosa lung biofilm. Microbial Pathogenesis, 2024, 197, pp.107020. ⟨10.1016/j.micpath.2024.107020⟩. ⟨hal-04807257⟩
    • Carla Faivre, Farras Daffa Imtiyaz, Julien Buyck, Sandrine Marchand, Melissa Marcotte, et al.. (E, E)-farnesol and myristic acid-loaded lipid nanoparticles overcome colistin resistance in Acinetobacter baumannii. International Journal of Pharmaceutics, 2024, 667 (A), pp.124907. ⟨10.1016/j.ijpharm.2024.124907⟩. ⟨hal-04766832⟩
    • Zahyra Kaouah, Julien Buyck, Maxime Pichon, Christophe Burucoa, Laure Prouvensier, et al.. In vitro efficacy of combinations of antibiotics used in clinical practice on clinical isolates of Helicobacter pylori. Helicobacter, 2024, 29 (3), pp.e13081. ⟨10.1111/hel.13081⟩. ⟨hal-04642228⟩
    • Jérémy Moreau, Thierry Noël, Kévin Point, Frederic Tewes, Luc Deroche, et al.. Pan-azole-resistant Meyerozyma guilliermondii clonal isolates harbouring a double F126L and L505F mutation in Erg11.. Mycoses, 2024, 67 (3), pp.e13704. ⟨10.1111/myc.13704⟩. ⟨hal-04715648⟩
    • Zahyra Kaouah, Julien Buyck, Maxime Pichon, Christophe Burucoa, Laure Prouvensier, et al.. Concentration-dependent effect of amoxicillin against clinical strains of Helicobacter pylori. Helicobacter, 2024, 29 (1), ⟨10.1111/hel.13044⟩. ⟨hal-04729706⟩
    • Mandeep Kaur, Julien Buyck, Frédéric Goormaghtigh, Jean-Luc Décout, Negar Mozaheb, et al.. Deficient Pseudomonas aeruginosa in MlaA/VacJ outer membrane lipoprotein shows decrease in rhamnolipids secretion, motility, and biofilm formation, and increase in fluoroquinolones susceptibility and innate immune response. Research in Microbiology, 2023, 174 (8), pp.104132. ⟨10.1016/j.resmic.2023.104132⟩. ⟨hal-04815770⟩
    • Simone Tunesi, Adrian Zelazny, Zeina Awad, Faiza Mougari, Julien Buyck, et al.. Antimicrobial susceptibility of Mycobacterium abscessus and treatment of pulmonary and extra-pulmonary infections. Clinical Microbiology and Infection, 2023, 67 (1), ⟨10.1016/j.cmi.2023.09.019⟩. ⟨hal-04473905⟩
    • Romain Aubry, Julien Buyck, Laure Prouvensier, Jean-Winoc Decousser, Patrice Nordmann, et al.. An improved PKPD modeling approach to characterize the pharmacodynamic interaction over time between ceftazidime/avibactam and colistin from in vitro time-kill experiments against multidrug-resistant Klebsiella pneumoniae isolates. Antimicrobial Agents and Chemotherapy, 2023, 67 (10), pp.e0030123. ⟨10.1128/aac.00301-23⟩. ⟨hal-04227324⟩
    • Luc Deroche, Vincent Aranzana-Climent, Albane Rozenholc, Laure Prouvensier, Léa Darnaud, et al.. Characterization of Pseudomonas aeruginosa resistance to ceftolozane-tazobactam due to ampC and/or ampD mutations observed during treatment using semi-mechanistic PKPD modeling. Antimicrobial Agents and Chemotherapy, 2023, ⟨10.1128/aac.00480-23⟩. ⟨hal-04227340⟩
    • Luc Deroche, Julien Buyck, Estelle Cateau, Sandrine Marchand, Kévin Brunet. Draft genome sequence of the Rhinocladiella similis clinical isolate CBS 149759. Mycopathologia, 2023, ⟨10.1007/s11046-023-00715-3⟩. ⟨hal-04088324⟩
    • Miriam Pinilla, Raoul Mazars, Romain Vergé, Leana Gorse, Margaux Paradis, et al.. EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption. Journal of Experimental Medicine, 2023, 220 (10), pp.e20230104. ⟨10.1084/jem.20230104⟩. ⟨hal-04805977⟩
    • Luc Deroche, Julien Buyck, Estelle Cateau, Blandine Rammaert, Sandrine Marchand, et al.. Draft Genome Sequence of Kazachstania bovina Yeast Isolated from Human Infection. Mycopathologia, 2022, 187 (4), pp.413-415. ⟨10.1007/s11046-022-00639-4⟩. ⟨hal-03906830⟩
    • Karin Santoni, David Pericat, Leana Gorse, Julien Buyck, Miriam Pinilla, et al.. Caspase-1-driven neutrophil pyroptosis and its role in host susceptibility to Pseudomonas aeruginosa. PLoS Pathogens, 2022, 18 (7), pp.e1010305. ⟨10.1371/journal.ppat.1010305⟩. ⟨hal-03738417⟩
    • Alexia Chauzy, Grace Akrong, Vincent Aranzana-Climent, Jérémy Moreau, Laure Prouvensier, et al.. PKPD Modeling of the Inoculum Effect of Acinetobacter baumannii on Polymyxin B in vivo. Frontiers in Pharmacology, 2022, 13, pp.842921. ⟨10.3389/fphar.2022.842921⟩. ⟨hal-03615739⟩
    • Grace Akrong, Alexia Chauzy, Vincent Aranzana-Climent, Mathilde Lacroix, Luc Deroche, et al.. A New Pharmacokinetic-Pharmacodynamic Model To Characterize the Inoculum Effect of Acinetobacter baumannii on Polymyxin B In Vitro. Antimicrobial Agents and Chemotherapy, 2022, 66 (1), pp.e0178921. ⟨10.1128/AAC.01789-21⟩. ⟨hal-03615758⟩
    • Chantal Valcourt, Julien Buyck, Nicolas Grégoire, William Couet, Sandrine Marchand, et al.. Lipid Nanoparticles Loaded with Farnesol or Geraniol to Enhance the Susceptibility of E. coli MCR-1 to Colistin. Pharmaceutics, 2021, 13 (11), pp.1849. ⟨10.3390/pharmaceutics13111849⟩. ⟨hal-03626643⟩
    • Johanna Ude, Vishwachi Tripathi, Julien Buyck, Sandra Söderholm, Olivier Cunrath, et al.. Outer membrane permeability: Antimicrobials and diverse nutrients bypass porins in Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (31), ⟨10.1073/pnas.2107644118⟩. ⟨hal-03615786⟩
    • Nicolas Grégoire, Alexia Chauzy, Julien Buyck, Blandine Rammaert, William Couet, et al.. Clinical Pharmacokinetics of Daptomycin. Clinical Pharmacokinetics, 2020, ⟨10.1007/s40262-020-00968-x⟩. ⟨hal-03071620⟩
    • Vincent Aranzana-Climent, Julien Buyck, Younes Smani, Jerónimo Pachón-Diaz, Sandrine Marchand, et al.. Semi-mechanistic PK-PD modelling of combined polymyxin B and minocycline against a polymyxin-resistant strain of Acinetobacter baumannii. Clinical Microbiology and Infection, 2020, ⟨10.1016/j.cmi.2020.01.017⟩. ⟨hal-02482129⟩
    • Alexia Chauzy, Bruna Gaelzer Silva Torres, Julien Buyck, Boudewijn Jonge, Christophe Adier, et al.. Semimechanistic Pharmacodynamic Modeling of Aztreonam‐Avibactam Combination to Understand Its Antimicrobial Activity Against Multidrug‐Resistant Gram‐Negative Bacteria. CPT: Pharmacometrics and Systems Pharmacology, 2019, ⟨10.1002/psp4.12452⟩. ⟨hal-02320523⟩
    • Shachi Mehta, Vincent Aranzana-Climent, Blandine Rammaert, Nicolas Grégoire, Sandrine Marchand, et al.. Preclinical Pharmacokinetic and Pharmacodynamic Data To Support Cefoxitin Nebulization for the Treatment of Mycobacterium abscessus. Antimicrobial Agents and Chemotherapy, 2019, 63 (7), ⟨10.1128/AAC.02651-18⟩. ⟨hal-02477844⟩
    • Alexia Chauzy, Julien Buyck, B.L.M. de Jonge, Sandrine Marchand, N. Grégoire, et al.. Pharmacodynamic modelling of β-lactam/β-lactamase inhibitor checkerboard data: illustration with aztreonam–avibactam. Clinical Microbiology and Infection, 2019, 25 (4), pp.515.e1-515.e4. ⟨10.1016/j.cmi.2018.11.025⟩. ⟨hal-02321069⟩
    • Olivier Cunrath, Dominik Meinel, Pauline Maturana, Joseph Fanous, Julien Buyck, et al.. Quantitative contribution of efflux to multi-drug resistance of clinical Escherichia coli and Pseudomonas aeruginosa strains. EBioMedicine, 2019, 41, pp.479-487. ⟨10.1016/j.ebiom.2019.02.061⟩. ⟨hal-02490365⟩
    • Ahalieyah Anantharajah, Julien Buyck, Charlotta Sundin, Paul Tulkens, Marie-Paule Mingeot-Leclercq, et al.. Salicylidene Acylhydrazides and Hydroxyquinolines Act as Inhibitors of Type Three Secretion Systems in Pseudomonas aeruginosa by Distinct Mechanisms. Antimicrobial Agents and Chemotherapy, 2017, 61 (6), pp.515.e1-515.e4. ⟨10.1128/AAC.02566-16⟩. ⟨hal-02490371⟩
    • Julien Buyck, C. Luyckx, G. Muccioli, K. Krause, W. Nichols, et al.. Pharmacodynamics of ceftazidime/avibactam against extracellular and intracellular forms of Pseudomonas aeruginosa. Journal of Antimicrobial Chemotherapy, 2017, pp.dkw587. ⟨10.1093/jac/dkw587⟩. ⟨hal-02490439⟩
    • Ahalieyah Anantharajah, Emmanuel Faure, Julien Buyck, Charlotta Sundin, Tuulikki Lindmark, et al.. Inhibition of the Injectisome and Flagellar Type III Secretion Systems by INP1855 Impairs Pseudomonas aeruginosa Pathogenicity and Inflammasome Activation. Journal of Infectious Diseases, 2016, 214 (7), pp.1105-1116. ⟨10.1093/infdis/jiw295⟩. ⟨hal-02490442⟩
    • Ahalieyah Anantharajah, Julien Buyck, Emmanuel Faure, Youri Glupczynski, Hector Rodriguez-Villalobos, et al.. Correlation between cytotoxicity induced by Pseudomonas aeruginosa clinical isolates from acute infections and IL-1β secretion in a model of human THP-1 monocytes. Pathogens and Disease, 2015, 73 (7), pp.ftv049. ⟨10.1093/femspd/ftv049⟩. ⟨hal-02490454⟩
    • Julien Buyck, Frédéric Peyrusson, Paul Tulkens, Françoise van Bambeke. RX-P873, a Novel Protein Synthesis Inhibitor, Accumulates in Human THP-1 Monocytes and Is Active against Intracellular Infections by Gram-Positive (Staphylococcus aureus) and Gram-Negative (Pseudomonas aeruginosa) Bacteria. Antimicrobial Agents and Chemotherapy, 2015, 59 (8), pp.4750-4758. ⟨10.1128/AAC.00428-15⟩. ⟨hal-02490457⟩
    • Julien Buyck, Paul Tulkens, Françoise van Bambeke. Activities of Antibiotic Combinations against Resistant Strains of Pseudomonas aeruginosa in a Model of Infected THP-1 Monocytes. Antimicrobial Agents and Chemotherapy, 2014, 59 (1), pp.258-268. ⟨10.1128/AAC.04011-14⟩. ⟨hal-02490461⟩
    • Guillaume Sautrey, Louis Zimmermann, Magali Deleu, Alicia Delbar, Luiza Souza Machado, et al.. New Amphiphilic Neamine Derivatives Active against Resistant Pseudomonas aeruginosa and Their Interactions with Lipopolysaccharides. Antimicrobial Agents and Chemotherapy, 2014, 58 (8), pp.4420 - 4430. ⟨10.1128/AAC.02536-13⟩. ⟨hal-01696330⟩
    • Julien Buyck, Paul Tulkens, Françoise van Bambeke. Pharmacodynamic Evaluation of the Intracellular Activity of Antibiotics towards Pseudomonas aeruginosa PAO1 in a Model of THP-1 Human Monocytes. Antimicrobial Agents and Chemotherapy, 2013, 57 (5), pp.2310-2318. ⟨10.1128/AAC.02609-12⟩. ⟨hal-02490468⟩
    • Julien Buyck, J.M. Buyck, V. Verriere, R. Benmahdi, G. Higgins, et al.. P. aeruginosa LPS stimulates calcium signaling and chloride secretion via CFTR in human bronchial epithelial cells. Journal of Cystic Fibrosis, 2013, 12 (1), pp.60-67. ⟨10.1016/j.jcf.2012.06.007⟩. ⟨hal-02490481⟩
    • J.M. Buyck, V. Verriere, R. Benmahdi, G. Higgins, B. Guery, et al.. P. aeruginosa LPS stimulates calcium signaling and chloride secretion via CFTR in human bronchial epithelial cells. Journal of Cystic Fibrosis, 2013, 12 (1), pp.60-67. ⟨10.1016/j.jcf.2012.06.007⟩. ⟨hal-03110544⟩
    • Julien Buyck, Patrick Plesiat, H. Traore, F. Vanderbist, Paul Tulkens, et al.. Increased Susceptibility of Pseudomonas aeruginosa to Macrolides and Ketolides in Eukaryotic Cell Culture Media and Biological Fluids Due to Decreased Expression of oprM and Increased Outer-Membrane Permeability. Clinical Infectious Diseases, 2012, 55 (4), pp.534 - 542. ⟨10.1093/cid/cis473⟩. ⟨hal-01695413⟩
    • Julien Buyck, Sophie Guénard, Patrick Plesiat, Paul Tulkens, Françoise van Bambeke. Role of MexAB-OprM in intrinsic resistance of Pseudomonas aeruginosa to temocillin and impact on the susceptibility of strains isolated from patients suffering from cystic fibrosis. Journal of Antimicrobial Chemotherapy, 2012, 67 (3), pp.771 - 775. ⟨10.1093/jac/dkr543⟩. ⟨hal-01695421⟩
    Communication dans un congrès (2 documents)
    • Zahyra Kaouah, Julien Buyck, Sandrine Marchand, Christophe Burucoa, Maxime Pichon, et al.. Concentration dependent effect of amoxicillin against clinical strains of Helicobacter pylori. 30ème Réunion du Groupe d'Études Français des Helicobacter (GEFH), Jun 2023, Lille, France. ⟨hal-04142680⟩
    • Luc Deroche, François Arrivé, Jean-Philippe Martellosio, Sandrine Marchand, Julien M Buyck. Development of cefiderocol resistance during treatment in Klebsiella pneumoniae. 33rd ECCMID, Apr 2023, Copenaghen, Denmark. ⟨hal-04142293⟩
    Pré-publication, Document de travail (1 document)
    • Shachi Mehta, Hariyanto Ih, Blandine Rammaert, William Couet, Sandrine Marchand, et al.. In vitro evaluation of novel bi-or tri-antibiotic combination against clinical isolates of Mycobacterium abscessus. 2020. ⟨hal-03027657⟩
    Chapitre d'ouvrage (1 document)
    • Julien Buyck, Sandrine Lemaire, Cristina Seral, Ahalieyah Anantharajah, Frédéric Peyrusson, et al.. In Vitro Models for the Study of the Intracellular Activity of Antibiotics. Methods in molecular biology, pp.147-157, 2016, ⟨10.1007/978-1-4939-2854-5_13⟩. ⟨hal-02490448⟩
    Thèse (1 document)
    • Julien Buyck. Rôles du calcium et des transports ioniques de l'épithélium des voies aériennes dans la réponse à l'agression septique par Pseudomonas aeruginosa.. Physiologie [q-bio.TO]. Université du Droit et de la Santé - Lille II, 2008. Français. ⟨NNT : ⟩. ⟨tel-00386909⟩

    Short CV:

    Dr. Julien Buyck (born 22.05.1980, France) is an Associate Professor of Microbiology at the University of Poitiers, School of Medicine and Pharmacy. He has been hired in 2016 as Maître de Conférences on a Joint chair INSERM – university of Poitiers to develop the microbiology / molecular biology field of the unit UMR 1070 « Pharmacology of Antimicrobial Agents ».

    He is a recognized expert in the biology and resistance of Gram-negative bacteria to antibiotics with more than 32 peer-reviewed publications, 3 book chapters and 7 oral communications in international meetings. He is familiar with in vitro assessment of antibiotics activity and he has developed during his last Post-doctoral fellow in Bumann’s laboratory in Biozentrum of Basel, strong skills about molecular biology to generate in frame deletions in bacteria, fluorescent gene reporters and screening methods in proteomics.

    He is co-director of 4 PhD students and he is coordinator of a JPIAMR project (ACOMa) and is involved in several ANR and JPIAMR project of the unit.

    Main recent publications:

         

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    INSERM U1070

    UFR de Médecine et Pharmacie - Université de Poitiers - Pôle Biologie Santé - Bâtiment B36
    1 rue Georges Bonnet
    86022 POITIERS Cedex, France

    (33) (0)5 49 45 49 69
    (33) (0)5 49 45 43 78

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