Inserm U1070 presents a strong activity in analytics to measure drug concentrations in various biological fluids (plasma, urine, broncho-alveoalar lavage, sputum, feces, …).

The platform is composed of 2 HPLC (High Performance Liquid Chromatography) with UV or fluorescence detectors and 2 Liquid Chromatography coupled with mass spectometers in tandem (LC-MS/MS quattro Micro Api, Waters France and TQ 3500, Apllied Biosystems, France).

HPLC with UV and fluorescence detectors

 

Liquid Chromatography coupled with tandem mass spectometers

 

All samples are treated in an extraction room  which provides all materials necessary to perform samples extraction (solvent cabinet, chemical hood, 2 systems for solid-liquid extraction, …).

 

We are able to dose more than 50 molecules among different matrix (like plasma, urine, feces, LCR, LBA and tissue) and different species (human, murines, porc, cows, goat, rabbit and monkey)

Analytes are :

Antibiotics:
Aminogycosides	β-lactams	Fluoroquinolones	Macrolides
Amikacin Gentamicin Kanamycin Tobramycin	Ampicillin Amoxicilin Aztreonam Cefotaxime Cefoxitin Ceftaroline Ceftazidime Ceftolozane Ceftriaxone Doripenem Ertapenem Meropenem Piperacillin Imipenem	Ciproflaxacin Grepafloxacin Levofloxacin Marbofloxacin Moxifloxacin Norfloxacin Pelfoxacin	Clarithromycin Clindamycin Streptomycin
Polymixins	Tetracyclines	Other antibioitics	β-lactamases inhibitors
Colistin Colistin Methanesulfonate Polymyxin B	Doxocycline Minocycline Oxytetracycline Tigecycline	Chloramphenicol Daptomycine Ethambutol Hydroxymetronidazole Isoniazid Linezolid Metronidazole Pyrazinamide Rifampicin Sulfamethoxazole Tedizolid Thiamphénicol Trimethoprim Vancomycin	Clavulanic acid Avibactam
Antifungal drugs	Antiviral drugs	Other drugs
Amphotericin B Anidulafungin Caspofungin Micafungin Voriconazole	Oseltamivir	Antipyrin Bromazepam Caffeine Cyclosporin Dopamine Fluticazone propionate Imatinib Mitotane Nicotine Olanzapine Acetaminophen Sinvastatin Sucrose Tacrolimus Urea Zosuquidar