Hélène Mirfendereski

Publications HAL

Mathilde Lacroix, Jérémy Moreau, Claudia Zampaloni, Caterina Bissantz, Hélène Mirfendereski, et al.. In vitro pharmacokinetic/pharmacodynamic modeling of the effect of mucin on polymyxin B activity against Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy, 2025, 69 (5), pp.112076. ⟨10.1128/aac.01535-24⟩. ⟨hal-05144888⟩
Maxime Vallée, Vincent Aranzana-Climent, Jérémy Moreau, Isabelle Lamarche, Théo Fontanier, et al.. Prediction of higher ceftazidime–avibactam concentrations in the human renal interstitium compared with unbound plasma using a minimal physiologically based pharmacokinetic model developed in rats and pigs through microdialysis. Antimicrobial Agents and Chemotherapy, 2025, ⟨10.1128/aac.01518-24⟩. ⟨hal-04950970⟩
Maxime Vallée, Jérémy Moreau, Théo Fontanier, Isabelle Lamarche, Hélène Mirfendereski, et al.. Étude de la distribution tissulaire du ceftazidime-avibactam dans le parenchyme rénal de rats et de porcs par technique de micro-dialyse. Progrès en Urologie - FMC, 2024, 34 (7), pp.S127-S128. ⟨10.1016/j.fpurol.2024.07.179⟩. ⟨hal-04906357⟩
Théo Fontanier, Isabelle Lamarche, Céline Barc, Vincent Aranzana-Climent, Hélène Mirfendereski, et al.. Distribution tissulaire du Meropeneme-Vaborbactam dans le rein et la prostate chez le rat et le cochon sain par micro-dialyse. Progrès en Urologie - FMC, 2024, 34 (7), pp.S134-S135. ⟨10.1016/j.fpurol.2024.07.188⟩. ⟨hal-04906538⟩
Maxime Vallée, Jérémy Moreau, Isabelle Lamarche, Céline Barc, Nathalie Kasal-Hoc, et al.. Tissue distribution of Ceftazidime-Avibactam in kidney tissue in healthy rats and pigs using a microdialysis technique. European Urology, 2024, Abstracts EAU24 - 39th Annual EAU Congress, 85 (Supplément 1), pp.S127-S128. ⟨hal-04913348⟩
Alexandre Maisterrena, Emmanuel Matas, Helene Mirfendereski, Anais Balbous, Sandrine Marchand, et al.. The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder. Biomolecules, 2022, 12 (11), pp.1691. ⟨10.3390/biom12111691⟩. ⟨hal-03906794⟩
Alexia Chauzy, Grace Akrong, Vincent Aranzana-Climent, Jérémy Moreau, Laure Prouvensier, et al.. PKPD Modeling of the Inoculum Effect of Acinetobacter baumannii on Polymyxin B in vivo. Frontiers in Pharmacology, 2022, 13, pp.842921. ⟨10.3389/fphar.2022.842921⟩. ⟨hal-03615739⟩
Jennifer Tardiveau, Lerica Leroux-Pullen, Ronette Gehring, Gaël Touchais, Marie-Pierre Chotard, et al.. A physiologically based pharmacokinetic (PBPK) model exploring the blood-milk barrier in lactating species - A case study with oxytetracycline administered to dairy cows and goats. Food and Chemical Toxicology, 2022, 161, pp.112848. ⟨10.1016/j.fct.2022.112848⟩. ⟨hal-03615752⟩
Mathieu Blot, Marine Jacquier, Laure-Anne Pauchard, Chloé Rebaud, Charline Marlin, et al.. Adverse Mechanical Ventilation and Pneumococcal Pneumonia Induce Immune and Mitochondrial Dysfunctions Mitigated by Mesenchymal Stem Cells in Rabbits. Anesthesiology, 2022, 136 (2), pp.293-313. ⟨10.1097/ALN.0000000000004083⟩. ⟨hal-03516221⟩
Efstratios Mainas, Olympia Apostolopoulou, Maria Siopi, Styliani Apostolidi, Efthymios Neroutsos, et al.. Comparative pharmacokinetics of the three echinocandins in ICU patients. Journal of Antimicrobial Chemotherapy, 2020, 75 (10), pp.2969-2976. ⟨10.1093/jac/dkaa265⟩. ⟨hal-03430259⟩
Stéphanie Badiou, Hélène Breton, Hélène Peyriere, Virginie Charasson, Arielle Crespel, et al.. Comparison of carbamazepine and oxcarbazepine effects on aminothiol levels. European Journal of Clinical Pharmacology, 2007, 64 (1), pp.83-87. ⟨10.1007/s00228-007-0388-z⟩. ⟨hal-05186811⟩
V Kontrimaviciute, H Breton, O Mathieu, J Mathieudaude, F Bressolle. Liquid chromatography–electrospray mass spectrometry determination of ibogaine and noribogaine in human plasma and whole bloodApplication to a poisoning involving Tabernanthe iboga root. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 2006, 843 (2), pp.131-141. ⟨10.1016/j.jchromb.2006.05.035⟩. ⟨hal-05186833⟩
Cédric Bès, Samuel Troadec, Myriam Chentouf, Hélène Breton, Anne Dominique Lajoix, et al.. PIN-bodies: a new class of antibody-like proteins with CD4 specificity derived from the protein inhibitor of neuronal nitric oxide synthase.. Biochemical and Biophysical Research Communications, 2006, 343 (1), pp.334-44. ⟨10.1016/j.bbrc.2006.02.126⟩. ⟨hal-00201221⟩
Dominique Hillaire-Buys, Jean-Pierre Blayac, Hélène Peyrière, Hélène Breton, Marylène Cociglio, et al.. Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms. British Journal of Dermatology, 2006, 155 (2), pp.422-428. ⟨10.1111/j.1365-2133.2006.07284.x⟩. ⟨hal-02910482⟩
Hélène Breton, Marylène Cociglio, Françoise Bressolle, Hélène Peyrière, Jean-Pierre Blayac, et al.. Liquid chromatography–electrospray mass spectrometry determination of carbamazepine, oxcarbazepine and eight of their metabolites in human plasma. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 2005, 828 (1-2), pp.80-90. ⟨10.1016/j.jchromb.2005.09.019⟩. ⟨hal-03061610⟩

Communication dans un congrès (4 documents)

Maxime Vallée, Jérémy Moreau, Théo Fontanier, Isabelle Lamarche, Hélène Mirfendereski, et al.. Étude de la distribution tissulaire du ceftazidime-avibactam dans le parenchyme rénal de rats et de porcs par technique de micro-dialyse. 118e Congrès français d’urologie, Association française d'urologie (AFU), Nov 2024, Paris, France. pp.S127-S128, ⟨10.1016/j.fpurol.2024.07.179⟩. ⟨hal-04906258⟩
Théo Fontanier, Isabelle Lamarche, Céline Barc, Vincent Aranzana-Climent, Hélène Mirfendereski, et al.. Distribution tissulaire du Meropeneme-Vaborbactam dans le rein et la prostate chez le rat et le cochon sain par micro-dialyse. 118e Congrès français d’urologie, Association française d'urologie (AFU), Nov 2024, Paris, France. pp.S134-S135. ⟨hal-04906501⟩
Alexia Chauzy, Fanny Bernard, Nicolas Grégoire, Hélène Mirfendereski, Nadia Imzi, et al.. Pkpop-LCR study: Pharmacokinetic and Pharmacodynamic of linezolid in neurointensive care patients with external ventricular drainage. 33rd ECCMID ; European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenaghen, Denmark. ⟨hal-04142302⟩
Helene Breton. New method LC/MS to indentify simultaneously carbamazepine and 8 of their metabolites in epileptic patient sera. Drug hypersensitivity meeting May, May 2004, Berne, Switzerland. ⟨hal-05186877⟩

Alexia Chauzy, William Couet, Isabelle Martin, Hélène Mirfendereski, Sandrine Marchand. In vitro evaluation of the inoculum effect of various β-lactamase-producing Klebsiella pneumoniae isolates on ceftazidime-avibactam. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain. ⟨hal-04571024⟩
Maxime Vallée, Céline Barc, Jérémy Moreau, Nathalie Kasal-Hoc, Isabelle Lamarche, et al.. Tissue distribution of Ceftazidime-Avibactam in kidney tissue in healthy rats and pigs using a microdialysis technique. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain. ⟨hal-04571042⟩
Maxime Vallée, Jérémy Moreau, Isabelle Lamarche, Céline Barc, Nathalie Kasal-Hoc, et al.. Tissue distribution of Ceftazidime-Avibactam in kidney tissue in healthy rats and pigs using a microdialysis technique. 39e Congrès de l'Association européenne d'urologie (EAU24), Apr 2024, Paris, France. , European Urology, 85 (Supplément 1), pp.S127-S128, Abstracts EAU24 - 39th Annual EAU Congress. ⟨10.1016/S0302-2838(24)00177-5⟩. ⟨hal-04906706⟩
Mathilde Lacroix, Alexia Chauzy, Claudia Zampaloni, Caterina Bissantz, Hélène Mirfendereski, et al.. In vitro PK/PD modelling of polymyxin B against resistant strain of A. baumannii in presence of mucin. 32nd ECCMID, Apr 2022, Lisabon, Portugal. ⟨hal-04016532⟩
Alexia Chauzy, Arthur Fourmy, Hélène Mirfendereski, William Couet, Sandrine Marchand. Comparison between pharmacokinetic-phramcodynamic modeling results of ceftaroline against methicillin-resistant Staphylococcus aureus after Time Kill and Hollow Fiber experiments. 32nd ECCMID, Apr 2022, Lisbonne, Portugal. ⟨hal-04014948⟩

Short CV:

Dr. Hélène Mirfendereski is a PhD-Engineer in Analytical Chemistry at the CHU of Poitiers. She has been hired in 2018 to performed HPLC-MS/MS method in biological matrices, before joining INSERM U1070, she had been working as Study director in Bioanalysis department at Galderma R&D for 11 years.

Research Area:

HPLC-MS/MS or conventional detector, samples preparations in biologic matrices, regulatory validations ( FDA, EMEA, GLP).

Research skills:

Bioanalysis: High performance liquid chromatography (HPLC) coupled to UV spectrometer and mass spectrometry (MS), Gaz chromatography (GC) coupled to mass spectrometer, samples preparation in biologic matrices, Analytical method validation

Software: Analayst 1.6.3; Mass lynx 4.1, Sciex OS

Knowledge: Nuclear Magnetic Resonance, IR Spectrometry, mass-mass, TOF, MALDI, drug study, Official guidelines (BPL, FDA).