Alexia Chauzy

  • Alexia Chauzy
Fil d'ariane
    • Associate Professor in Pharmacokinetics
    • INSERM U1070 "Pharmacology of anti-infective agents"
      Pôle Biologie Santé
      1 rue Georges Bonnet
      86022 Poitiers cedex
      France
    • +33 (0)5 49 45 49 28
    • Research area: Pharmacokinetics

      Key-words: PK-PD modeling, Hollow fiber, antibiotic combination

    Publications HAL

    Article dans une revue (15 documents)
    • Noémie Prébonnaud, Alexia Chauzy, Nicolas Grégoire, Claire Dahyot-Fizelier, Christophe Adier, et al.. A freely accessible, adaptable hollow-fiber setup to reproduce first-order absorption: illustration with linezolid cerebrospinal fluid pharmacokinetic data. Microbiology Spectrum, 2025, ⟨10.1128/spectrum.00051-25⟩. ⟨hal-05085650⟩
    • Mathilde Lacroix, Jérémy Moreau, Claudia Zampaloni, Caterina Bissantz, Hamasseh Shirvani, et al.. Impact of nutritional factors on in vitro PK/PD modelling of polymyxin B against various strains of Acinetobacter baumannii. International Journal of Antimicrobial Agents, 2024, 64 (1), pp.107189. ⟨10.1016/j.ijantimicag.2024.107189⟩. ⟨hal-04643050⟩
    • E. de Pablo, P. O'Connell, R. Fernández-García, S. Marchand, A. Chauzy, et al.. Targeting lung macrophages for fungal and parasitic pulmonary infections with innovative amphotericin B dry powder inhalers. International Journal of Pharmaceutics, 2023, 635, pp.122788. ⟨10.1016/j.ijpharm.2023.122788⟩. ⟨hal-04131635⟩
    • Alexia Chauzy, Nicolas Grégoire, Martine Ferrandière, Sigismond Lasocki, Karim Ashenoune, et al.. Population pharmacokinetic/pharmacodynamic study suggests continuous infusion of ceftaroline daily dose in ventilated critical care patients with early-onset pneumonia and augmented renal clearance. Journal of Antimicrobial Chemotherapy, 2022, 77 (11), pp.3173-3179. ⟨10.1093/jac/dkac299⟩. ⟨hal-03906736⟩
    • Alexia Chauzy, Salim Bouchène, Vincent Aranzana-Climent, Jonathan Clarhaut, Christophe Adier, et al.. A Minimal Physiologically Based Pharmacokinetic Model to Characterize CNS Distribution of Metronidazole in Neuro Care ICU Patients. Antibiotics, 2022, 11 (10), pp.1293. ⟨10.3390/antibiotics11101293⟩. ⟨hal-03906712⟩
    • Alexia Chauzy, Grace Akrong, Vincent Aranzana-Climent, Jérémy Moreau, Laure Prouvensier, et al.. PKPD Modeling of the Inoculum Effect of Acinetobacter baumannii on Polymyxin B in vivo. Frontiers in Pharmacology, 2022, 13, pp.842921. ⟨10.3389/fphar.2022.842921⟩. ⟨hal-03615739⟩
    • Kévin Brunet, Cheikh Diop, Alexia Chauzy, Noémie Prébonnaud, Sandrine Marchand, et al.. Improved In Vitro Anti-Mucorales Activity and Cytotoxicity of Amphotericin B with a Pegylated Surfactant. Journal of Fungi, 2022, 8 (2), pp.121. ⟨10.3390/jof8020121⟩. ⟨hal-03615762⟩
    • Grace Akrong, Alexia Chauzy, Vincent Aranzana-Climent, Mathilde Lacroix, Luc Deroche, et al.. A New Pharmacokinetic-Pharmacodynamic Model To Characterize the Inoculum Effect of Acinetobacter baumannii on Polymyxin B In Vitro. Antimicrobial Agents and Chemotherapy, 2022, 66 (1), pp.e0178921. ⟨10.1128/AAC.01789-21⟩. ⟨hal-03615758⟩
    • Nicolas Grégoire, Alexia Chauzy, Julien Buyck, Blandine Rammaert, William Couet, et al.. Clinical Pharmacokinetics of Daptomycin. Clinical Pharmacokinetics, 2020, ⟨10.1007/s40262-020-00968-x⟩. ⟨hal-03071620⟩
    • Alexia Chauzy, H Ih, M Jacobs, S Marchand, N Grégoire, et al.. Sequential time-kill: a simple experimental trick to discriminate between PK/PD models with distinct heterogeneous sub-populations versus homogenous population with adaptive resistance. Antimicrobial Agents and Chemotherapy, 2020, ⟨10.1128/AAC.00788-20⟩. ⟨hal-02888859⟩
    • Alexia Chauzy, Bruna Gaelzer Silva Torres, Julien Buyck, Boudewijn Jonge, Christophe Adier, et al.. Semimechanistic Pharmacodynamic Modeling of Aztreonam‐Avibactam Combination to Understand Its Antimicrobial Activity Against Multidrug‐Resistant Gram‐Negative Bacteria. CPT: Pharmacometrics and Systems Pharmacology, 2019, ⟨10.1002/psp4.12452⟩. ⟨hal-02320523⟩
    • Alexia Chauzy, Julien Buyck, B.L.M. de Jonge, Sandrine Marchand, N. Grégoire, et al.. Pharmacodynamic modelling of β-lactam/β-lactamase inhibitor checkerboard data: illustration with aztreonam–avibactam. Clinical Microbiology and Infection, 2019, 25 (4), pp.515.e1-515.e4. ⟨10.1016/j.cmi.2018.11.025⟩. ⟨hal-02321069⟩
    • Alexia Chauzy, Abdelouaïd Nadji, Jean-Christophe Combes, Nadine Defrance, Belaid Bouhemad, et al.. Cerebrospinal fluid pharmacokinetics of ceftaroline in neurosurgical patients with an external ventricular drain. Journal of Antimicrobial Chemotherapy, 2019, 74 (3), pp.675-681. ⟨10.1093/jac/dky489⟩. ⟨hal-01957116⟩
    • Alexia Chauzy, Isabelle Lamarche, Christophe Adier, William Couet, Sandrine Marchand. Microdialysis Study of Aztreonam-Avibactam Distribution in Peritoneal Fluid and Muscle of Rats with or without Experimental Peritonitis. Antimicrobial Agents and Chemotherapy, 2018, 62 (10), ⟨10.1128/AAC.01228-18⟩. ⟨hal-02321070⟩
    • Sandrine Marchand, Alexia Chauzy, Claire Dahyot-Fizelier, William Couet. Microdialysis as a way to measure antibiotics concentration in tissues. Pharmacological Research, 2016, 111, pp.201-207. ⟨10.1016/j.phrs.2016.06.001⟩. ⟨hal-02321071⟩
    Pré-publication, Document de travail (1 document)
    • Noémie Prébonnaud, Alexia Chauzy, Nicolas Grégoire, Claire Dahyot-Fizelier, Christophe Adier, et al.. A freely accessible, adaptable hollow-fiber setup to reproduce first-order absorption: illustration with linezolid cerebrospinal fluid pharmacokinetic data. 2025. ⟨hal-05030769⟩
    Poster (11 documents)
    • Noémie Prébonnaud, Alexia Chauzy, Christophe Adier, Isabelle Martin, Claire Dahyot-Fizelier, et al.. Impact of in vitro use of artificial cerebrospinal fluid compared to Mueller-Hinton broth on the efficacy of linezolid against Staphylococcus aureus in a hollow-fiber model. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain. ⟨hal-04571091⟩
    • Alexia Chauzy, William Couet, Isabelle Martin, Hélène Mirfendereski, Sandrine Marchand. In vitro evaluation of the inoculum effect of various β-lactamase-producing Klebsiella pneumoniae isolates on ceftazidime-avibactam. 34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain. ⟨hal-04571024⟩
    • Mathilde Lacroix, Jérémy Moreau, Claudia Zampaloni, Caterina Bissantz, Hamasseh Shirvani, et al.. PK/PD modelling of the CAMHB nutrients concentrations effect on polymyxin B antimicrobial activity against Acinetobacter baumannii. 33rd ECCMID : European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenaghen, Denmark. ⟨hal-04141371⟩
    • Mathilde Lacroix, Alexia Chauzy, Claudia Zampaloni, Caterina Bissantz, Hélène Mirfendereski, et al.. In vitro PK/PD modelling of polymyxin B against resistant strain of A. baumannii in presence of mucin. 32nd ECCMID, Apr 2022, Lisabon, Portugal. ⟨hal-04016532⟩
    • Alexia Chauzy, Arthur Fourmy, Hélène Mirfendereski, William Couet, Sandrine Marchand. Comparison between pharmacokinetic-phramcodynamic modeling results of ceftaroline against methicillin-resistant Staphylococcus aureus after Time Kill and Hollow Fiber experiments. 32nd ECCMID, Apr 2022, Lisbonne, Portugal. ⟨hal-04014948⟩
    • Alexia Chauzy, Salim Bouchène, Nicolas Grégoire, William Couet, Olivier Mimoz, et al.. A minimal physiologically-based pharmacokinetic model to investigate CNS distribution of metronidazole in ICU patients. 39ème Réunion Interdisciplinaire de Chimiothérapie Anti-Infectieuse (RICAI), Dec 2019, Paris, France. ⟨hal-02528416⟩
    • Alexia Chauzy, Bruna Gaelzer Silva Torres, Julien Buyck, Boudewijn Jonge, Christophe Adier, et al.. Semi-mechanistic pharmacodynamics modeling of aztreonam- avibactam combination to understand its antimicrobial activity against multidrug-resistant Gram(-) bacteria. PAGE meeting, Jun 2019, Stockholm, Sweden. ⟨hal-02528382⟩
    • Alexia Chauzy, Bruna Gaelzer Silva Torres, Julien Buyck, Emma Marquizeau, Patrice Gobin, et al.. Semi-mechanistic pharmacokinetic/pharmacodynamics modeling of aztreonam-avibactam combination against multidrug resistant Gram(-) organisms. the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2018, Madrid, Spain. ⟨hal-02528294⟩
    • Pascal Chavanet, Alexia Chauzy, Nadine Defrance, Abdelouaïd Nadji, Jean-Christophe Combes, et al.. Cerebrospinal fluid pharmacokinetics of ceftaroline in neurosurgical patients with external ventricular drain. the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2018, Madrid, Spain. ⟨hal-02528340⟩
    • Alexia Chauzy, Nicolas Grégoire, Isabelle Lamarche, Patrice Gobin, William Couet, et al.. Microdialysis study distribution of aztreonam and avibactam in skeletal muscle and intraperitoneal fluid of rats with or without experimental peritonitis. the 27th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2017, Vienne, Austria. ⟨hal-02512109⟩
    • Alexia Chauzy, Nicolas Grégoire, Sandrine Marchand, Olivier Mimoz, Marc Paccalin, et al.. Appraisal of potential effect of subcutaneous administration on antibiotics pharmacokinetics-pharmacodynamics. the 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2015, Copenhague, Denmark. ⟨hal-02512083⟩
    Communication dans un congrès (4 documents)
    • Mathilde Lacroix, Andrej Trauner, Claudia Zampaloni, Caterina Bissantz, Hamasseh Shirvani, et al.. Transcriptomic data to support in vitro semimechanistic PK/PD modelling of Polymyxin B against Acinetobacter baumannii. 33rd ECCMID, Apr 2023, Copenaghen, Denmark. ⟨hal-04142283⟩
    • Noémie Prebonnaud, Alexia Chauzy, Claire Dahyot-Fizelier, Sandrine Marchand. Predicting antibacterial efficacy of linezolid on Staphylococcus aureus in cerebral infections using in vitro hollow fiber model and pharmacokinetic-pharmacodynamic modeling. 33rd ECCMID : : European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenaghen, Denmark. ⟨hal-04142287⟩
    • Alexia Chauzy, Fanny Bernard, Nicolas Grégoire, Hélène Mirfendereski, Nadia Imzi, et al.. Pkpop-LCR study: Pharmacokinetic and Pharmacodynamic of linezolid in neurointensive care patients with external ventricular drainage. 33rd ECCMID ; European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenaghen, Denmark. ⟨hal-04142302⟩
    • Alexia Chauzy. Pharmacodynamic modeling of checkerboard data obtained with β-lactam- β-lactamases inhibitor combination: aztreonam-avibactam. ISAP/EPASG Scientific Meeting, Apr 2017, Vienne, Austria. ⟨hal-02512124⟩
    Thèse (1 document)
    • Alexia Chauzy. Evaluation pharmacocinétique/pharmacodynamique in vitro et in vivo de l'association aztréonam-avibactam. Sciences du Vivant [q-bio]. Université de poitiers, 2018. Français. ⟨NNT : ⟩. ⟨tel-02533170⟩

    Short CV:

    Dr. Alexia Chauzy (born 06.08.1989, France) is Assistant Professor of Pharmacology at the University of Poitiers, School of Medicine and Pharmacy. She studied Pharmacy at the University of Poitiers and joined the unit UMR 1070 « Pharmacology of Antimicrobial Agents » in 2014 in order to perform her PhD, during which she investigated in vitro and in vivo pharmacokinetic-pharmacodynamic (PK-PD) of aztreonam-avibactam, in the context of an IMI project (Combacte-Care).

    She is mostly interested in population PK, PK-PD and PBPK modeling of antibiotics. She is also familiar with in vivo (microdialysis) and in vitro (time-kill curves, checkerboard) experiments to characterize the tissue distribution and efficacy of antibiotics alone or in combination. She recently developed an in-house hollow fiber infection model to study the in vitro efficacy of antibiotics by mimicking their pharmacokinetics in a patient.

    She is currently co-director of 2 PhD students.

    Main recent publications:

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    • Find us on

    INSERM U1070

    UFR de Médecine et Pharmacie - Université de Poitiers - Pôle Biologie Santé - Bâtiment B36
    1 rue Georges Bonnet
    86022 POITIERS Cedex, France

    (33) (0)5 49 45 49 69
    (33) (0)5 49 45 43 78

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