Patrice Gobin


research area : Analytical Chemistry and Quality approach

Key words: Colistin; Liquid Chromatography-Tandem Mass Spectrometry; Pharmacokinetics


tel: (33) 5 49 45 49 69

Address: INSERM U1070 Pôle Biologie Santé 1 rue Georges Bonnet 86022 Poitiers cedex France

Main recent publications:

Colistin distribution in the peritoneal fluid of a patient with several peritonitis. Mimoz O, Petipas F, Gregoire N, Gobin P, Marchand S, Couet W.
Antimicrob Agents Chemother. 2012, jul; 56(7):4035-6.

Convulsions and apnoea in a patient infected with New Delhi metallo-ß-lactamase-1 Escheichia coli treated with colistin. Spapen HD, Honore PM, Gregoire N, Gobin P, de Regt J, Martens GA, Pierard D, Couet W. J Infect. 2011, Dec,63(6):468-70.

Assay of colistin and colistin methanesulfonate in plasma and urine by liquid chromatography-tandem mass spectrometry. Gobin P, Lemaître F, Marchand S, Couet W, Olivier JC. Antimicrob Agents Chemother. 2010 May;54(5):1941-8. doi: 10.1128/AAC.01367-09. Epub 2010 Feb 22.

Dose-ranging pharmacokinetics of colistin methanesulphonate (CMS) and colistin in rats following single intravenous CMS doses. Marchand S, Lamarche I, Gobin P, Couet W. J Antimicrob Chemother. 2010 Aug;65(8):1753-8. doi: 10.1093/jac/dkq183. Epub 2010 May 27.

Aerosol therapy with colistin methanesulfonate: a biopharmaceutical issue illustrated in rats. Marchand S, Gobin P, Brillault J, Baptista S, Adier C, Olivier JC, Mimoz O, Couet W. Antimicrob Agents Chemother. 2010 Sep;54(9):3702-7. doi: 10.1128/AAC.00411-10. Epub 2010 Jun 14.


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