Isabelle Lamarche


research area : Pharmacokinetics

Key words: Small animal experimentation, microdialysis, HPLC


tel: (33) 5 49 45 49 69

Address: INSERM U1070 Pôle Biologie Santé 1 rue Georges Bonnet 86022 Poitiers cedex France

Main recent publications:

A preclinical pharmacokinetic modeling approach to the biopharmaceutical characterization of immediate and microsphere-based sustained release pulmonary formulations of rifampicin. Doan TV, Grégoire N, Lamarche I, Gobin P, Marchand S, Couet W, Olivier JC. Eur J Pharm Sci. 2012 Nov 16;48(1-2):223-230. doi: 10.1016/j.ejps.2012.10.024.

Modeling approach to characterize intraocular doripenem pharmacokinetics after intravenous administration to rabbits, with tentative extrapolation to humans. Semoun O, Marchand S, Grégoire N, Lamarche I, Adier C, Laroche L, Goldschmidt P, Couet W. Antimicrob Agents Chemother. 2012 Jul;56(7):3531-4. doi: 10.1128/AAC.06329-11. Epub 2012 Apr 23.

Dose-ranging pharmacokinetics of colistin methanesulphonate (CMS) and colistin in rats following single intravenous CMS doses. Marchand S, Lamarche I, Gobin P, Couet W. J Antimicrob Chemother. 2010 Aug;65(8):1753-8. doi: 10.1093/jac/dkq183. Epub 2010 May 27.

Microdialysis study of imipenem distribution in the peritoneal fluid of rats with experimental acute pancreatitis. Lefeuvre S, Marchand S, Pariat C, Lamarche I, Couet W. Antimicrob Agents Chemother. 2008 Apr;52(4):1516-8. doi: 10.1128/AAC.01474-07. Epub 2008 Jan 14.

Microdialysis study of imipenem distribution in the intraperitoneal fluid of rats with or without experimental peritonitis. Lefeuvre S, Marchand S, Lamarche I, Mimoz O, Couet W. Antimicrob Agents Chemother. 2006 Jan;50(1):34-7.


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