William Couet

Professor of Clinical Pharmacy

William Couet
Research area: Pharmacokinetics

Key words: Microdialysis, PK-PD modeling, colistin, aerosol, transporters



tel: (33) 5 49 45 43 79

Address: INSERM U1070
Pôle Biologie Santé
1 rue Georges Bonnet
86022 Poitiers cedex

Main recent publications:

Colistin pharmacokinetics: the fog is lifting. Couet W, Grégoire N, Marchand S, Mimoz O. Clin Microbiol Infect. 2012 Jan;18(1):30-9.

Pharmacokinetics of colistin and colistimethate sodium after a single 80-mg intravenous dose of CMS in young healthy volunteers. Couet W, Grégoire N, Gobin P, Saulnier PJ, Frasca D, Marchand S, Mimoz O. Clin Pharmacol Ther. 2011 Jun;89(6):875-9.

Semimechanistic pharmacokinetic-pharmacodynamic model with adaptation development for time-kill experiments of ciprofloxacin against Pseudomonas aeruginosa. Grégoire N, Raherison S, Grignon C, Comets E, Marliat M, Ploy MC, Couet W. Antimicrob Agents Chemother. 2010 Jun;54(6):2379-84.

P-glycoprotein-mediated transport of moxifloxacin in a Calu-3 lung epithelial cell model. Brillault J, De Castro WV, Harnois T, Kitzis A, Olivier JC, Couet W. Antimicrob Agents Chemother. 2009 Apr;53(4):1457-62.

Application of basic pharmacokinetic concepts to analysis of microdialysis data: illustration with imipenem muscle distribution. Dahyot C, Marchand S, Bodin M, Debeane B, Mimoz O, Couet W. Clin Pharmacokinet. 2008;47(3):181-9.


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