Nicolas Grégoire

Assitant Professor

Nicolas Grégoire
Research area: Modelling of pharmacokinetics and phamacodynamics

Key words: Modelling, Pharmacokinetics, Pharmacodynamics, anti-infective drugs.


tel: (33) 5 49 36 64 36

Address: INSERM U1070
Pôle Biologie Santé
1 rue Georges Bonnet
86022 Poitiers cedex

Main recent publications:

A preclinical pharmacokinetic modeling approach to the biopharmaceutical characterization of immediate and microsphere-based sustained release pulmonary formulations of rifampicin.
Doan TV, Grégoire N, Lamarche I, Gobin P, Marchand S, Couet W, Olivier JC.
Eur J Pharm Sci. 2012 Nov 16;48(1-2):223-230. [Epub ahead of print]

Colistin pharmacokinetics: the fog is lifting.
Couet W, Grégoire N, Marchand S, Mimoz O.
Clin Microbiol Infect. 2012 Jan;18(1):30-9.

Broad-Spectrum ss-Lactam Antibiotics for Treating Experimental Peritonitis in Mice Due a Klebsiella pneumoniae Producing the Carbapenemase OXA-48.
Mimoz O, Grégoire N, Poirel L, Marliat M, Couet W, Nordmann P.
Antimicrob Agents Chemother. 2012 May;56(5):2759-60..

Pharmacokinetics of colistin and colistimethate sodium after a single 80-mg intravenous dose of CMS in young healthy volunteers.
Couet W, Grégoire N, Gobin P, Saulnier PJ, Frasca D, Marchand S, Mimoz O.
Clin Pharmacol Ther. 2011 Jun;89(6):875-9.

Semimechanistic pharmacokinetic-pharmacodynamic model with adaptation development for time-kill experiments of ciprofloxacin against Pseudomonas aeruginosa.
Grégoire N, Raherison S, Grignon C, Comets E, Marliat M, Ploy MC, Couet W.
Antimicrob Agents Chemother. 2010 Jun;54(6):2379-84.



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