Julien Brillault

Assistant Professor

Research area: Cell biology

Key words: Cell culture, In vitro drug transport, physiological barrier, efflux pumps



tel: (33) 5 49 45 49 44

Address: INSERM U1070
Pôle Biologie Santé
1 rue Georges Bonnet
86022 Poitiers cedex

Main recent publications:

In vitro biopharmaceutical evaluation of ciprofloxacin/metal cation complexes for pulmonary administration.
Brillault J, Tewes F, Couet W, Olivier JC.
Eur J Pharm Sci. 2017 Jan 15;97:92-98. doi: 10.1016/j.ejps.2016.11.011. Epub 2016 Nov 15.

Ciprofloxacin-Loaded Inorganic-Organic Composite Microparticles To Treat Bacterial Lung Infection.
Tewes F, Brillault J, Lamy B, O’Connell P, Olivier JC, Couet W, Healy AM.
Mol Pharm. 2016 Jan 4;13(1):100-12. doi: 10.1021/acs.molpharmaceut.5b00543. Epub 2015 Dec 19.

Biopharmaceutical characterization of nebulized antimicrobial agents in rats: 1. Ciprofloxacin, moxifloxacin, and grepafloxacin.
Gontijo AV, Brillault J, Grégoire N, Lamarche I, Gobin P, Couet W, Marchand S.
Antimicrob Agents Chemother. 2014 Jul;58(7):3942-9. doi: 10.1128/AAC.02818-14. Epub 2014 May 5

Formulation and in vitro characterization of inhalable polyvinyl alcohol-free rifampicin-loaded PLGA microspheres prepared with sucrose palmitate as stabilizer: efficiency for ex vivo alveolar macrophage targeting.
Diab R, Brillault J, Bardy A, Gontijo AV, Olivier JC.
Int J Pharm. 2012 Oct 15;436(1-2):833-9. doi: 10.1016/j.ijpharm.2012.07.036. Epub 2012 Jul 28.

Relative contributions of active mediated transport and passive diffusion of fluoroquinolones with various lipophilicities in a Calu-3 lung epithelial cell model.
Brillault J, De Castro WV, Couet W.
Antimicrob Agents Chemother. 2010 Jan;54(1):543-5. doi: 10.1128/AAC.00733-09. Epub 2009 Oct 12.

P-glycoprotein-mediated transport of moxifloxacin in a Calu-3 lung epithelial cell model.
Brillault J, De Castro WV, Harnois T, Kitzis A, Olivier JC, Couet W.
Antimicrob Agents Chemother. 2009 Apr;53(4):1457-62. doi: 10.1128/AAC.01253-08. Epub 2009 Feb 2.

Formulation of rifampicin-cyclodextrin complexes for lung nebulization.
Tewes F, Brillault J, Couet W, Olivier JC.
J Control Release. 2008 Jul 14;129(2):93-9. doi: 10.1016/j.jconrel.2008.04.007. Epub 2008 Apr 20.



Menu principal

Haut de page