Denis Frasca

Assitant Professor of Anesthesiology

Research area: Pharmacokinetics

Key words: Intensive care, Microdialysis, PK-PD modeling


tel: (33) 5 49 44 38 95

Address: C. H. U. de Poitiers
Service d’Anesthésie-Réanimation
2 rue de la Milétrie
86000 Poitiers

Main recent publications:

Brain microdialysis distribution study of cefotaxime in a patient with traumatic brain injury.
Frasca D, Dahyot-Fizelier C, Couet W, Debaene B, Mimoz O, Marchand S.
Br J Anaesth. 2012 Nov;109(5):830-1. doi: 10.1093/bja/aes369.

Pharmacokinetics of colistin and colistimethate sodium after a single 80-mg intravenous dose of CMS in young healthy volunteers.
Couet W, Grégoire N, Gobin P, Saulnier PJ, Frasca D, Marchand S, Mimoz O.
Clin Pharmacol Ther. 2011 Jun;89(6):875-9. doi: 10.1038/clpt.2011.48. Epub 2011 May 4.

Accuracy of a continuous noninvasive hemoglobin monitor in intensive care unit patients.
Frasca D, Dahyot-Fizelier C, Catherine K, Levrat Q, Debaene B, Mimoz O.
Crit Care Med. 2011 Oct;39(10):2277-82. doi: 10.1097/CCM.0b013e3182227e2d.

Pharmacokinetics of ertapenem following intravenous and subcutaneous infusions in patients.
Frasca D, Marchand S, Petitpas F, Dahyot-Fizelier C, Couet W, Mimoz O.
Antimicrob Agents Chemother. 2010 Feb;54(2):924-6. doi: 10.1128/AAC.00836-09. Epub 2009 Nov 23.


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