2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008


Magréault S, Mankikian J, Marchand S, Diot P, Couet W, Flament T, Grégoire N.  Pharmacokinetics of colistin after nebulization or intravenous administration of colistin methansulphonate (Colimycin) to cystic fibrosis patients. Journal of Cystic Fibrosis september 2019.

Fantin B, Poujade J, Grégoire N, Chau F, Roujansky A, Kieffer N, Berleur M, Couet W, Nordmann P. The inoculum effect of Escherichia coli expressing mcr-1 or not on colistin activity in a murine model of peritonitis. Clin Microbiol Infect. 2019 Sep 5. pii: S1198-743X(19)30484-7. doi: 10.1016/j.cmi.2019.08.021. PMID:31494253

Chauzy A, Gaelzer Silva Torres B, Buyck J, de Jonge B, Adier C, Marchand S, Couet W, Grégoire N. Semimechanistic Pharmacodynamic Modeling of Aztreonam-Avibactam Combination to Understand Its Antimicrobial Activity Against Multidrug-Resistant Gram-Negative Bacteria. CPT Pharmacometrics Syst Pharmacol. 2019 Aug 16. doi: 10.1002/psp4.12452. PMID: 31420947

Barbara LamyDolores Remedios Serrano, Peter O’Connell, William CouetSandrine Marchand, Anne Marie Healy, Frederic Tewes. Use of leucine to improve aerodynamic properties of ciprofloxacin-loaded maltose microparticles for inhalation. Eur. J. Pharm. Res. 2019, Vol. 1, Issue 1, p. 2-11. doi: 10.34154/2019-EJPR.01(01).pp-02-11/euraass

BGS Torres, R Awad, S Marchand, W Couet, F Tewes. In vitro evaluation of Pseudomonas aeruginosa chronic lung infection models: Are agar and calcium-alginate beads interchangeable? European Journal of Pharmaceutics and Biopharmaceutics 2019, 143, 35-43.

Nurbaeti SN, Brillault J, Tewes F, Olivier JC. Sustained-release microparticle dry powders of chloramphenicol palmitate or thiamphenicol palmitate prodrugs for lung delivery as aerosols. Eur J Pharm Sci. 2019 Aug 1:105028. doi: 10.1016/j.ejps.2019.105028.PMID: 31377132

Marchand S, Grégoire N, Couet W. Pharmacokinetics of Polymyxins in Animals. Adv Exp Med Biol. 2019;1145:89-103. doi: 10.1007/978-3-030-16373-0_7. PMID:31364073

Boisson M, Torres BGS, Yani S, Couet W, Mimoz O, Dahyot-Fizelier C, Marchand S, Grégoire N. Reassessing the dosing of cefoxitin prophylaxis during major abdominal surgery: insights from microdialysis and population pharmacokinetic modelling.J Antimicrob Chemother. 2019 Jul 1;74(7):1975-1983. doi: 10.1093/jac/dkz139. PMID: 31220258

Boisson M, Corbi P, Kerforne T, Camilleri L, Debauchez M, Demondion P, Eljezi V, Flecher E, Lepelletier D, Leprince P, Nesseler N, Nizou JY, Roussel JC, Rozec B, Ruckly S, Lucet JC, Timsit JF, Mimoz O. Multicentre, open-label, randomised, controlled clinical trial comparing 2% chlorhexidine-70% isopropanol and 5% povidone iodine-69% ethanol for skin antisepsis in reducing surgical-site infection after cardiac surgery: the CLEAN 2 study protocol. BMJ Open. 2019 Jun 17;9(6):e026929. doi: 10.1136/bmjopen-2018-026929.

Tewes F, Bahamondez-Canas TF, Smyth HDC. Efficacy of Ciprofloxacin and Its Copper Complex against Pseudomonas aeruginosa Biofilms. AAPS PharmSciTech. 2019 May 29;20(5):205. doi: 10.1208/s12249-019-1417-9. PMID:31144198

Brunet T, Brunet K, Jouvion G, Cateau E, Marchand S, Rammaert B. Lichtheimia corymbifera colonization leading to pulmonary infection can be prevented with liposomal Amphotericin B in a new murine model. Antimicrob Agents Chemother. 2019 May 28. pii: AAC.02544-18. doi: 10.1128/AAC.02544-18. PMID: 31138564

Mehta S, Aranzana-Climent V, Rammaert B, Grégoire N, Marchand S, Couet W, Buyck JM. Pre-clinical pharmacokinetic and pharmacodynamic data to support cefoxitin nebulization for the treatment of Mycobacterium abscessus. Antimicrob Agents Chemother. 2019 May 6. pii: AAC.02651-18. doi: 10.1128/AAC.02651-18. PMID: 31061149

Carrez R, Brillault J, Grégoire N, Lamarche I, Laroche J, Couet W, Marchand S. Pulmonary Pharmacokinetics of Oseltamivir Carboxylate in Rats after Nebulization or Intravenous Administration of its Prodrug Oseltamivir Phosphate. Antimicrob Agents Chemother. 2019 Apr 8. pii: AAC.00074-19. doi: 10.1128/AAC.00074-19. PMID:30962337

Chauzy A, Buyck J, de Jonge BLM, Marchand S, Grégoire N, Couet W. Pharmacodynamic modelling of β-lactam/β-lactamase inhibitor checkerboard data: illustration with aztreonam-avibactam. Clin Microbiol Infect. 2019 Apr;25(4):515.e1-515.e4. doi: 10.1016/j.cmi.2018.11.025.  PMID:30543853

Martin C, Auboyer C, Boisson M, Dupont H, Gauzit R, Kitzis M, Leone M, Lepape A, Mimoz O, Montravers P, Pourriat JL; Steering committee of the French Society of Anaesthesia and Intensive Care Medicine (SFAR) responsible for the establishment of the guidelines. Antibioprophylaxis in surgery and interventional medicine (adult patients). Update 2017.  Anaesth Crit Care Pain Med. 2019 Mar 2. pii: S2352-5568(19)30085-2. doi: 10.1016/j.accpm.2019.02.017. [Epub ahead of print] PMID: 30836191

Chauzy A, Nadji A, Combes JC, Defrance N, Bouhemad B, Couet W, Chavanet P. Cerebrospinal fluid pharmacokinetics of ceftaroline in neurosurgical patients with an external ventricular drain. J Antimicrob Chemother. 2019 Mar 1;74(3):675-681. doi: 10.1093/jac/dky489. PMID:30535190

Grégoire N, Marchand S, Ferrandière M, Lasocki S, Seguin P, Vourc’h M, Barbaz M, Gaillard T, Launey Y, Asehnoune K, Couet W, Mimoz O. Population pharmacokinetics of daptomycin in critically ill patients with various degrees of renal impairment. J Antimicrob Chemother. 2019 Jan 1;74(1):117-125. doi: 10.1093/jac/dky374. PMID:30295740


Brunet K, Alanio A, Lortholary O, Rammaert B. Reactivation of dormant/latent fungal infection.  J Infect. 2018 Dec;77(6):463-468. doi: 10.1016/j.jinf.2018.06.016. Epub 2018 Jul 6.

Boisson M, Mimoz O, Hadzic M, Marchand S, Adier C, Couet W, Gregoire N. Pharmacokinetics of intravenous and nebulized gentamicin in critically ill patients. J Antimicrob Chemother. 2018 Oct

Marchand S, Boisson M, Mehta S, Adier C, Mimoz O,  Grégoire N, and Couet W. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 6. Aminoglycosides. Antimicrob Agents Chemother. 2018 Sep.

Chauzy A., Nadji A., Combes J.C., Defrance N., Bouhemad B., Couet W., Chavanet P. Cerebrospinal fluid pharmacokinetics of ceftaroline in neurosurgical patients with an external ventricular drain. J Antimicrob Chemother. 2018.

Chauzy A., Buyck J., de Jonge B.L.M., Marchand S., Grégoire N., Couet W. Pharmacodynamic modeling of β-lactam/β-lactamase inhibitor checkerboard data: illustration with aztreonam-avibactam. Clin Microbiol Infect. 2018.

Chauzy A, Lamarche I, Adier C, Couet W, Marchand S. Microdialysis Study of Aztreonam-Avibactam Distribution in Peritoneal Fluid and Muscle of Rats with or without Experimental Peritonitis. Antimicrob Agents Chemother. 2018 Jul

TF Bahamondez-Canas, H Zhang, F Tewes, J Leal, HDC Smyth. PEGylation of Tobramycin Improves Mucus Penetration and Antimicrobial Activity against Pseudomonas aeruginosa Biofilms in Vitro. Mol Pharm. 2018 Apr

Etienne M, Simon S, Antoine E, Etienne C, Blandine R, Matthieu M, Didier R, France R. Osteoarticular manifestations of Q fever: a case series and literature review. Clin Microbiol Infect. 2018 Mar

Viel A, Henri J, Bouchène S, Laroche J, Rolland JG, Manceau J, Laurentie M, Couet W, Grégoire N. A Population WB-PBPK Model of Colistin and its Prodrug CMS in Pigs: Focus on the Renal Distribution and Excretion. Pharm Res. 2018 Mar

Grégoire M, Libois JB, Waast D, Gaborit B, Dauty M, Deslandes G, Dailly E, Touchais S, Boutoille D, Grégoire N, Couet W. Pharmacokinetics of Tedizolid in an Obese Patient after Bariatric Surgery. Antimicrob Agents Chemother. 2018 Mar

Dahyot-Fizelier C, Marchand S, Lipman J. Is augmented renal clearance the Holy Grail of antibiotic therapy failure in ventilator-acquired pneumonia? Anaesth Crit Care Pain Med. 2018 Feb

Lamy B, Tewes F, Serrano DR, Lamarche I, Gobin P, Couet W, Healy AM, Marchand S. New aerosol formulation to control ciprofloxacin pulmonary concentration. J Control Release. 2018 Feb

Nurbaeti SN, Olivier JC, Adier C, Marchand S, Couet W, Brillault J. Active Mediated Transport of Chloramphenicol and Thiamphenicol in a Calu-3 Lung Epithelial Cell Model. J Pharm Sci. 2018 Apr

Sophie Magréault, Nicolas Grégoire, Sandrine Marchand, William Couet. Colistin Pharmacokinetics in Pediatrics. Clinical Infectious Diseases, Volume 66, Issue 5, 10 February 2018


Alexis Viel, Jérôme Henri, Agnès Perrin-Guyomard, Julian Laroche, William Couet, Nicolas Grégoire, Michel Laurentie. Lack of experimental evidence to support positive  strain selection during oral administration of colistin at recommended and higher dose given by gavage in weaned piglets. International Journal of Antimicrobial Agents, 2017.

Ehrhardt C, Bäckman P, Couet W, Edwards C, Forbes B, Fridén M, Gumbleton M, Hosoya KI, Kato Y, Nakanishi T, Takano M, Terasaki T, Yumoto R. Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs. J Pharm Sci. 2017 Sep;106(9):2234-2244. doi: 10.1016/j.xphs.2017.04.011. Epub 2017 Apr 15. Review. PMID: 28416418

Boisson M, Grégoire N, Cormier M, Gobin P, Marchand S, Couet W, Mimoz O. Pharmacokinetics of nebulized colistin methanesulfonate in critically ill patients.J Antimicrob Chemother. 2017 Jun 1. doi: 10.1093/jac/dkx167.

Grégoire N, Aranzana-Climent V, Magréault S, Marchand S, Couet W.Clinical Pharmacokinetics and Pharmacodynamics of Colistin.Clin Pharmacokinet. 2017 May 26. doi: 10.1007/s40262-017-0561-1.

Yamamoto Y, Välitalo PA, van den Berg DJ, Hartman R, van den Brink W, Wong YC, Huntjens DR, Proost JH, Vermeulen A, Krauwinkel W, Bakshi S, Aranzana-Climent V, Marchand S, Dahyot-Fizelier C, Couet W, Danhof M, van Hasselt JG, de Lange EC. A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations.Pharm Res. 2017 Feb;34(2):333-351.

J Brillault, F Tewes, W Couet, JC Olivier. In vitro biopharmaceutical evaluation of ciprofloxacin/metal cation complexes for pulmonary administration.Eur J Pharm Sci. 2017 Jan


Tewes F, Brillault J, Lamy B, O’Connell P, Olivier JC, Couet W, Healy AM. Ciprofloxacin-Loaded Inorganic-Organic Composite Microparticles To Treat Bacterial Lung Infection. Mol Pharm. 2016 Jan 4;13(1):100-12.

Jacobs M, Grégoire N, Mégarbane B, Gobin P, Balayn D, Marchand S, Mimoz O, Couet W. Population Pharmacokinetics of Colistin Methanesulfonate and Colistin in Critically Ill Patients with Acute Renal Failure Requiring Intermittent Hemodialysis. Antimicrob Agents Chemother. 2016 Jan 4;60(3):1788-93.

Tewes F, Gobbo OL, Ehrhardt C, Healy AM. Amorphous Calcium Carbonate Based-Microparticles for Peptide Pulmonary Delivery. ACS Appl Mater Interfaces. 2016 Jan 20;8(2):1164-75.

Roblot F, Robin S, Chubilleau C, Giraud J, Bouffard B, Ingrand P. Vaccination coverage in French 17-year-old young adults: an assessment of mandatory and recommended vaccination statuses. Epidemiol Infect. 2016 Feb;144(3):612-7.

Loupec T, Frasca D, Rousseau N, Faure JP, Mimoz O, Debaene B. Appropriate dosing of sugammadex to reverse deep rocuronium-induced neuromuscular blockade in morbidly obese patients. Anaesthesia. 2016 Mar;71(3):265-72.

Jacobs M, Grégoire N, Couet W, Bulitta JB. Distinguishing Antimicrobial Models with Different Resistance Mechanisms via Population Pharmacodynamic Modeling. PLoS Comput Biol. 2016 Mar 11;12(3):e1004782. doi: 10.1371/journal.pcbi.1004782.

Marchand S, Grégoire N, Brillault J, Lamarche I, Gobin P, Couet W. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats. 4. Aztreonam. Antimicrob Agents Chemother. 2016 Apr 22;60(5):3196-8.

Lemaire X, Bonnet E, Castan B, Forestier E, Lescure FX, Roblot F, Pulcini C. Management of non-necrotizing cellulitis in France. Med Mal Infect. 2016 May 26. pii: S0399

Fillâtre P, Revest M, Belaz S, Robert-Gangneux F, Zahar JR, Roblot F, Tattevin P. [Pneumocystosis in non-HIV-infected immunocompromised patients]. Rev Med Interne. 2016 May;37(5):327-36.

Garcia M, Le Moal G, Godet C, Beraud G, Chagneau-Derrode C, Roblot F. First case report of renal improvement on tenofovir alafenamide in an HIV/hepatitis B virus-coinfected patient with adefovir-induced Fanconi’s syndrome. AIDS. 2016 Jun 1;30(9):1487-8.

Marchand S, Chauzy A, Dahyot-Fizelier C, Couet W. Microdialysis as a way to measure antibiotics concentration in tissues. Pharmacol Res. 2016 Sep;111:201-207. doi: 10.1016/j.phrs.2016.06.001. Epub 2016 Jun 11. Review

Galindo Bedor DC, Marchand S, Lamarche I, Laroche J, Pereira de Santana D, Couet W. BBiopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 5. Oseltamivir Carboxylate. Antimicrob Agents Chemother. 2016 Jul 22;60(8):5085-7. doi: 10.1128/AAC.00909-16.

Maiguy-Foinard A, Genay S, Lannoy D, Barthélémy C, Lebuffe G, Debaene B, Odou P, Décaudin B. Criteria for choosing an intravenous infusion line intended for multidrug infusion in anaesthesia and intensive care units. Anaesth Crit Care Pain Med. 2016 Jun 20. pii: S2352-5568(16)30056-X.

Loupec T, Frasca D, Debaene B. Dose of sugammadex in morbidly obese patients – a reply. Anaesthesia. 2016 Jun;71(6):731-2.

Le Coz P, Carlet J, Roblot F, Pulcini C. Human resources needed to perform antimicrobial stewardship teams’ activities in French hospitals. Med Mal Infect. 2016 Jun;46(4):200-6.

Godet C, Laurent F, Bergeron A, Ingrand P, Beigelman-Aubry C, Camara B, Cottin V, Germaud P, Philippe B, Pison C, Toper C, Carette MF, Frat JP, Béraud G, Roblot F, Cadranel J; ACHROSCAN Study Group. CT Imaging Assessment of Response to Treatment in Chronic Pulmonary Aspergillosis. Chest. 2016 Jul;150(1):139-47.

Gaspar MC, Grégoire N, Sousa JJ, Pais AA, Lamarche I, Gobin P, Olivier JC, Marchand S, Couet W. Pulmonary pharmacokinetics of levofloxacin in rats after aerosolization of immediate-release chitosan or sustained-release PLGA microspheres. Eur J Pharm Sci. 2016 Oct 10;93:184-91. doi: 10.1016/j.ejps.2016.08.024. Epub 2016 Aug 13.

Le Devendec L, Mourand G, Bougeard S, Léaustic J, Jouy E, Keita A, Couet W, Rousset N, Kempf I. Impact of colistin sulfate treatment of broilers on the presence of resistant bacteria and resistance genes in stored or composted manure. Vet Microbiol. 2016 Oct 15;194:98-106. doi: 10.1016/j.vetmic.2015.11.012.

Couet W. Pharmacokinetic/pharmacodynamic studies in the CMI. Clin Microbiol Infect. 2016 Oct;22(10):821. doi: 10.1016/j.cmi.2016.08.005. Epub 2016 Aug 20.

Fleury MA, Jouy E, Eono F, Cariolet R, Couet W, Gobin P, Le Goff O, Blanquet-Diot S, Alric M, Kempf I. Impact of two different colistin dosing strategies on healthy piglet fecal microbiota.  Res Vet Sci. 2016 Aug;107:152-160. doi: 10.1016/j.rvsc.2016.06.003. Epub 2016 Jun 8.


Ratajczak-Enselme M, Gregoire N, Estebe J-P, Dollo G, Chevanne F, Bec D, Ecoffey C, Couet W, Le Corre P. Population Pharmacokinetics of Amitriptyline After Intrathecal, Epidural, and Intravenous Administration in Sheep. Reg Anesth Pain Med. 2015 Dec;40(6):681–6.

Guechi Y, Pichot A, Frasca D, Rayeh-Pelardy F, Lardeur J-Y, Mimoz O. Assessment of noninvasive acoustic respiration rate monitoring in patients admitted to an Emergency Department for drug or alcoholic poisoning. J Clin Monit Comput. 2015 Dec;29(6):721–6.

Mimoz O, Lucet J-C, Kerforne T, Pascal J, Souweine B, Goudet V, Mercat A, Bouadma L, Lasocki S, Alfandari S, Friggeri A, Wallet F, Allou N, Ruckly S, Balayn D, Lepape A, Timsit J-F. Skin antisepsis with chlorhexidine-alcohol versus povidone iodine-alcohol, with and without skin scrubbing, for prevention of intravascular-catheter-related infection (CLEAN): an open-label, multicentre, randomised, controlled, two-by-two factorial trial. Lancet. 2015 Nov 21;386(10008):2069–77.

Godet C, Laurent F, Beraud G, Toper C, Camara B, Philippe B, Germaud P, Cottin V, Beigelman-Aubry C, Khalil A, Blouin P, Pouriel M, Roblot F, Bergeron A, Cadranel J. Phenotyping chronic pulmonary aspergillosis by cluster analysis. Eur Respir J. 2015 Nov;46(5):1509–12.

Marchand S, Gregoire N, Brillault J, Lamarche I, Gobin P, Couet W. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 3. Tobramycin. Antimicrob Agents Chemother. 2015 Oct;59(10):6646–7.

Marchand S, Bouchene S, de Monte M, Guilleminault L, Montharu J, Cabrera M, Gregoire N, Gobin P, Diot P, Couet W, Vecellio L. Pharmacokinetics of Colistin Methansulphonate (CMS) and Colistin after CMS Nebulisation in Baboon Monkeys. Pharm Res. 2015 Oct;32(10):3403–14.

Gaspar MC, Sousa JJS, Pais AACC, Cardoso O, Murtinho D, Serra MES, Tewes F, Olivier J-C. Optimization of levofloxacin-loaded crosslinked chitosan microspheres for inhaled aerosol therapy. Eur J Pharm Biopharm. 2015 Oct;96:65–75.

Hutchinson PJ, Jalloh I, Helmy A, Carpenter KLH, Rostami E, Bellander B-M, Boutelle MG, Chen JW, Claassen J, Dahyot-Fizelier C, Enblad P, Gallagher CN, Helbok R, Hillered L, Le Roux PD, Magnoni S, Mangat HS, Menon DK, Nordstrom C-H, O’Phelan KH, Oddo M, Perez Barcena J, Robertson C, Ronne-Engstrom E, Sahuquillo J, Smith M, Stocchetti N, Belli A, Carpenter TA, Coles JP, Czosnyka M, Dizdar N, Goodman JC, Gupta AK, Nielsen TH, Marklund N, Montcriol A, O’Connell MT, Poca MA, Sarrafzadeh A, Shannon RJ, Skjoth-Rasmussen J, Smielewski P, Stover JF, Timofeev I, Vespa P, Zavala E, Ungerstedt U. Consensus statement from the 2014 International Microdialysis Forum. Intensive Care Med. 2015 Sep;41(9):1517–28.

Pham D-D, Gregoire N, Couet W, Gueutin C, Fattal E, Tsapis N. Pulmonary delivery of pyrazinamide-loaded large porous particles. Eur J Pharm Biopharm. 2015 Aug;94:241–50.

Drouet M, Chai F, Barthelemy C, Lebuffe G, Debaene B, Decaudin B, Odou P. Endothelial Cell Toxicity of Vancomycin Infusion Combined with Other Antibiotics. Antimicrob Agents Chemother. 2015 Aug;59(8):4901–6.

Payen DM, Guilhot J, Launey Y, Lukaszewicz AC, Kaaki M, Veber B, Pottecher J, Joannes-Boyau O, Martin-Lefevre L, Jabaudon M, Mimoz O, Coudroy R, Ferrandiere M, Kipnis E, Vela C, Chevallier S, Mallat J, Robert R. Early use of polymyxin B hemoperfusion in patients with septic shock due to peritonitis: a multicenter randomized control trial. Intensive Care Med. 2015 Jun;41(6):975–84.

Leone M, Bechis C, Baumstarck K, Ouattara A, Collange O, Augustin P, Annane D, Arbelot C, Asehnoune K, Baldesi O, Bourcier S, Delapierre L, Demory D, Hengy B, Ichai C, Kipnis E, Brasdefer E, Lasocki S, Legrand M, Mimoz O, Rimmele T, Aliane J, Bertrand P-M, Bruder N, Klasen F, Friou E, Levy B, Martinez O, Peytel E, Piton A, Richter E, Kamel T, Vogler M-C, Wallet F, Boufi M, Allaouchiche B, Constantin J-M, Martin C, Jaber S, Lefrant J-Y. Erratum to: Outcome of acute mesenteric ischemia in the intensive care unit: a retrospective, multicenter study of 780 cases. Intensive Care Med. 2015 May;41(5):966–8.

Amaro MI, Tewes F, Gobbo O, Tajber L, Corrigan OI, Ehrhardt C, Healy AM. Formulation, stability and pharmacokinetics of sugar-based salmon calcitonin-loaded nanoporous/nanoparticulate microparticles (NPMPs) for inhalation. Int J Pharm. 2015 Apr 10;483(1–2):6–18.

Perez M, Decaudin B, Foinard A, Barthelemy C, Debaene B, Lebuffe G, Odou P. Compatibility of medications during multi-infusion therapy: A controlled in vitro study on a multilumen infusion device. Anaesth Crit Care Pain Med. 2015 Apr;34(2):83–8.

Matzneller P, Gobin P, Lackner E, Zeitlinger M. Feasibility of microdialysis for determination of protein binding and target site pharmacokinetics of colistin in vivo. J Clin Pharmacol. 2015 Apr;55(4):431–7.

Leone M, Bechis C, Baumstarck K, Ouattara A, Collange O, Augustin P, Annane D, Arbelot C, Asehnoune K, Baldesi O, Bourcier S, Delapierre L, Demory D, Hengy B, Ichai C, Kipnis E, Brasdefer E, Lasocki S, Legrand M, Mimoz O, Rimmele T, Aliane J, Bertrand P-M, Bruder N, Klasen F, Friou E, Levy B, Martinez O, Peytel E, Piton A, Richter E, Toufik K, Vogler M-C, Wallet F, Boufi M, Allaouchiche B, Constantin J-M, Martin C, Jaber S, Lefrant J-Y. Outcome of acute mesenteric ischemia in the intensive care unit: a retrospective, multicenter study of 780 cases. Intensive Care Med. 2015 Apr;41(4):667–76.

Godet C, Goudet V, Laurent F, Le Moal G, Gounant V, Frat J-P, Cateau E, Roblot F, Cadranel J. Nebulised liposomal amphotericin B for Aspergillus lung diseases: case series and literature review. Mycoses. 2015 Mar;58(3):173–80.

Nation RL, Li J, Cars O, Couet W, Dudley MN, Kaye KS, Mouton JW, Paterson DL, Tam VH, Theuretzbacher U, Tsuji BT, Turnidge JD. Framework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus. Lancet Infect Dis. 2015 Feb;15(2):225–34.

Drouet M, Chai F, Barthelemy C, Lebuffe G, Debaene B, Decaudin B, Odou P. Influence of vancomycin infusion methods on endothelial cell toxicity. Antimicrob Agents Chemother. 2015 Feb;59(2):930–4.

Barham AS, Tewes F, Healy AM. Moisture diffusion and permeability characteristics of hydroxypropylmethylcellulose and hard gelatin capsules. Int J Pharm. 2015 Jan 30;478(2):796–803.

Mimoz O, Montravers P, Paiva J-A. Continuous administration of linezolid in pneumonia: what is the level of proof? Intensive Care Med. 2015 Jan;41(1):157–9.

Jayle CPM, Allain G, Ingrand P, Laksiri L, Bonnin E, Hajj-Chahine J, Mimoz O, Corbi P. Flail chest in polytraumatized patients: surgical fixation using Stracos reduces ventilator time and hospital stay. Biomed Res Int. 2015;2015:624723.


Godet C, Le Goff J, Beby-Defaux A, Robin M, Raffoux E, Arnulf B, Roblot F, Frat JP, Maillard N, Tazi A, Bergeron A. Human metapneumovirus pneumonia in patients with hematological malignancies. J Clin Virol. 2014 Dec;61(4):593–6.

Boisson M, Jacobs M, Gregoire N, Gobin P, Marchand S, Couet W, Mimoz O. Comparison of intrapulmonary and systemic pharmacokinetics of colistin methanesulfonate (CMS) and colistin after aerosol delivery and intravenous administration of CMS in critically ill patients. Antimicrob Agents Chemother. 2014 Dec;58(12):7331–9.

Mercier T, Tissot F, Gardiol C, Corti N, Wehrli S, Guidi M, Csajka C, Buclin T, Couet W, Marchetti O, Decosterd LA. High-throughput hydrophilic interaction chromatography coupled to tandem mass spectrometry for the optimized quantification of the anti-Gram-negatives antibiotic colistin A/B and its pro-drug colistimethate. J Chromatogr A. 2014 Nov 21;1369:52–63.

Lasocki S, Chudeau N, Papet T, Tartiere D, Roquilly A, Carlier L, Mimoz O, Seguin P, Malledant Y, Asehnoune K, Hamel JF. Prevalence of iron deficiency on ICU discharge and its relation with fatigue: a multicenter prospective study. Crit Care. 2014 Sep 30;18(5):542.

Asehnoune K, Seguin P, Allary J, Feuillet F, Lasocki S, Cook F, Floch H, Chabanne R, Geeraerts T, Roger C, Perrigault PF, Hanouz JL, Lukaszewicz AC, Biais M, Boucheix P, Dahyot-Fizelier C, Capdevila X, Mahe PJ, Le Maguet P, Paugam-Burtz C, Gergaud S, Plaud B, Constantin JM, Malledant Y, Flet L, Sebille V, Roquilly A. Hydrocortisone and fludrocortisone for prevention of hospital-acquired pneumonia in patients with severe traumatic brain injury (Corti-TC): a double-blind, multicentre phase 3, randomised placebo-controlled trial. Lancet Respir Med. 2014 Sep;2(9):706–16.

Garcia M, Le Moal G, Dupuis A, Rochette N, Roblot F, Venisse N. Plasma exchange significantly affects darunavir exposure. J Antimicrob Chemother. 2014 Aug;69(8):2296–7.

Million M, Roblot F, Carles D, D’Amato F, Protopopescu C, Carrieri MP, Raoult D. Reevaluation of the risk of fetal death and malformation after Q Fever. Clin Infect Dis. 2014 Jul 15;59(2):256–60.

Gontijo AVL, Gregoire N, Lamarche I, Gobin P, Couet W, Marchand S. Biopharmaceutical characterization of nebulized antimicrobial agents in rats: 2. Colistin. Antimicrob Agents Chemother. 2014 Jul;58(7):3950–6.

Gontijo AVL, Brillault J, Gregoire N, Lamarche I, Gobin P, Couet W, Marchand S. Biopharmaceutical characterization of nebulized antimicrobial agents in rats: 1. Ciprofloxacin, moxifloxacin, and grepafloxacin. Antimicrob Agents Chemother. 2014 Jul;58(7):3942–9.

Conte B, Zoric L, Bonada G, Debaene B, Ripart J. Reversal of a rocuronium-induced grade IV anaphylaxis via early injection of a large dose of sugammadex. Can J Anaesth. 2014 Jun;61(6):558–62.

Le Maguet P, Roquilly A, Lasocki S, Asehnoune K, Carise E, Saint Martin M, Mimoz O, Le Gac G, Somme D, Cattenoz C, Feuillet F, Malledant Y, Seguin P. Prevalence and impact of frailty on mortality in elderly ICU patients: a prospective, multicenter, observational study. Intensive Care Med. 2014 May;40(5):674–82.

Roquilly A, Seguin P, Mimoz O, Feuillet F, Rosenczweig E, Chevalier F, Loutrel O, Malledant Y, Sebille V, Asehnoune K. Risk factors for prolonged duration of mechanical ventilation in acute traumatic tetraplegic patients–a retrospective cohort study. J Crit Care. 2014 Apr;29(2):313.e7-13.

Laribi S, Kansao J, Borderie D, Collet C, Deschamps P, Ababsa R, Mouniam L, Got L, Leon A, Thoannes H, Santin A, Kouyoumdjian J-C, Dahyot-Fizelier C, Millet C, Golmard J-L, Beaudeux J-L. S100B blood level measurement to exclude cerebral lesions after minor head injury: the multicenter STIC-S100 French study. Clin Chem Lab Med. 2014 Apr;52(4):527–36.

Roblot F, Le Moal G, Kauffmann-Lacroix C, Bastides F, Boutoille D, Verdon R, Godet C, Tattevin P. Pneumocystis jirovecii pneumonia in HIV-negative patients: a prospective study with focus on immunosuppressive drugs and markers of immune impairment. Scand J Infect Dis. 2014 Mar;46(3):210–4.

Vitorino C, Almeida A, Sousa J, Lamarche I, Gobin P, Marchand S, Couet W, Olivier J-C, Pais A. Passive and active strategies for transdermal delivery using co-encapsulating nanostructured lipid carriers: in vitro vs. in vivo studies. Eur J Pharm Biopharm. 2014 Feb;86(2):133–44.

Swaminathan J, Gobbo OL, Tewes F, Healy AM, Ehrhardt C. Encapsulation into PEG-liposomes does not improve the bioavailability of pulmonary delivered salmon calcitonin. J Aerosol Med Pulm Drug Deliv. 2014 Feb;27(1):1–11.

de Castro WV, Marchand S, Lamarche I, Couet W. Effect of experimentally induced hypovolemia on ertapenem tissue distribution using microdialysis in rats. Eur J Pharm Sci. 2014 Jan 23;51:45–50.

Tewes F, Ehrhardt C, Healy AM. Superparamagnetic iron oxide nanoparticles (SPIONs)-loaded Trojan microparticles for targeted aerosol delivery to the lung. Eur J Pharm Biopharm. 2014 Jan;86(1):98–104.

Seguin P, Laviolle B, Dahyot-Fizelier C, Dumont R, Veber B, Gergaud S, Asehnoune K, Mimoz O, Donnio P-Y, Bellissant E, Malledant Y. Effect of oropharyngeal povidone-iodine preventive oral care on ventilator-associated pneumonia in severely brain-injured or cerebral hemorrhage patients: a multicenter, randomized controlled trial. Crit Care Med. 2014 Jan;42(1):1–8.

Nation RL, Li J, Cars O, Couet W, Dudley MN, Kaye KS, Mouton JW, Paterson DL, Tam VH, Theuretzbacher U, Tsuji BT, Turnidge JD. Consistent global approach on reporting of colistin doses to promote safe and effective use. Clin Infect Dis. 2014 Jan;58(1):139–41.

Salama A, Fichou N, Allard M, Dubreil L, De Beaurepaire L, Viel A, Jegou D, Bosch S, Bach J-M. MicroRNA-29b modulates innate and antigen-specific immune responses in mouse models of autoimmunity. PLoS One. 2014;9(9):e106153.

Frasca D, Dahyot-Fizelier C, Adier C, Mimoz O, Debaene B, Couet W, Marchand S. Metronidazole and hydroxymetronidazole central nervous system distribution: 2. cerebrospinal fluid concentration measurements in patients with external ventricular drain. Antimicrob Agents Chemother. 2014;58(2):1024–7.

Frasca D, Dahyot-Fizelier C, Adier C, Mimoz O, Debaene B, Couet W, Marchand S. Metronidazole and hydroxymetronidazole central nervous system distribution: 1. microdialysis assessment of brain extracellular fluid concentrations in patients with acute brain injury. Antimicrob Agents Chemother. 2014;58(2):1019–23.


Loupec T, Petitpas F, Kalfon P, Mimoz O. Subglottic secretion drainage in prevention of ventilator-associated pneumonia: mind the gap between studies and reality. Crit Care. 2013 Dec 9;17(6):R286.

Timsit J-F, Bouadma L, Mimoz O, Parienti J-J, Garrouste-Orgeas M, Alfandari S, Plantefeve G, Bronchard R, Troche G, Gauzit R, Antona M, Canet E, Bohe J, Herrault M-C, Schwebel C, Ruckly S, Souweine B, Lucet J-C. Jugular versus femoral short-term catheterization and risk of infection in intensive care unit patients. Causal analysis of two randomized trials. Am J Respir Crit Care Med. 2013 Nov 15;188(10):1232–9.

Bianco S, Tewes F, Tajber L, Caron V, Corrigan OI, Healy AM. Bulk, surface properties and water uptake mechanisms of salt/acid amorphous composite systems. Int J Pharm. 2013 Nov 1;456(1):143–52.

Tewes F, Paluch KJ, Tajber L, Gulati K, Kalantri D, Ehrhardt C, Healy AM. Steroid/mucokinetic hybrid nanoporous microparticles for pulmonary drug delivery. Eur J Pharm Biopharm. 2013 Nov;85(3 Pt A):604–13.

Payen J-F, Genty C, Mimoz O, Mantz J, Bosson J-L, Chanques G. Prescribing nonopioids in mechanically ventilated critically ill patients. J Crit Care. 2013 Aug;28(4):534.e7-12.

Marchand S, Lauda M, Le Moal G, Gobin P, Couet W, Roblot F. Pharmacokinetics of daptomycin in a patient with severe renal failure not receiving dialysis. Antimicrob Agents Chemother. 2013 Jun;57(6):2898–9.

Jacolot A, Judel C, Louchahi K, Tod M, Marchand S, Petitjean O, Mimoz O. How to solve the problem of spontaneous bacterial clearance when testing new antibiotic treatment: results on experimental pneumonia due to a derepressed cephalosporinase-producing Enterobacter cloacae. Fundam Clin Pharmacol. 2013 Jun;27(3):239–43.

Dahyot-Fizelier C, Frasca D, Gregoire N, Adier C, Mimoz O, Debaene B, Couet W, Marchand S. Microdialysis study of cefotaxime cerebral distribution in patients with acute brain injury. Antimicrob Agents Chemother. 2013 Jun;57(6):2738–42.

Goudet V, Timsit J-F, Lucet J-C, Lepape A, Balayn D, Seguin S, Mimoz O. Comparison of four skin preparation strategies to prevent catheter-related infection in intensive care unit (CLEAN trial): a study protocol for a randomized controlled trial. Trials. 2013 Apr 27;14:114.

Foinard A, Decaudin B, Barthelemy C, Debaene B, Odou P. The impact of multilumen infusion devices on the occurrence of known physical drug incompatibility: a controlled in vitro study. Anesth Analg. 2013 Jan;116(1):101–6.


Timsit J-F, Mimoz O, Mourvillier B, Souweine B, Garrouste-Orgeas M, Alfandari S, Plantefeve G, Bronchard R, Troche G, Gauzit R, Antona M, Canet E, Bohe J, Lepape A, Vesin A, Arrault X, Schwebel C, Adrie C, Zahar J-R, Ruckly S, Tournegros C, Lucet J-C. Randomized controlled trial of chlorhexidine dressing and highly adhesive dressing for preventing catheter-related infections in critically ill adults. Am J Respir Crit Care Med. 2012 Dec 15;186(12):1272–8.

Gobbo OL, Zurek M, Tewes F, Ehrhardt C, Cremillieux Y. Manganese: a new contrast agent for lung imaging? Contrast Media Mol Imaging. 2012 Dec;7(6):542–6.

Mimoz O. Chlorhexidine is better than aqueous povidone iodine as skin antiseptic for preventing surgical site infections. Infect Control Hosp Epidemiol. 2012 Sep;33(9):961–2.

Robert R, Mehaud J-E, Timricht N, Goudet V, Mimoz O, Debaene B. Benefits of an early cooling phase in continuous renal replacement therapy for ICU patients. Ann Intensive Care. 2012 Aug 23;2(1):40.

Seguin P, Roquilly A, Mimoz O, Le Maguet P, Asehnoune K, Biederman S, Carise E, Malledant Y. Risk factors and outcomes for prolonged versus brief fever: a prospective cohort study. Crit Care. 2012 Aug 13;16(4):R150.

Foinard A, Decaudin B, Barthelemy C, Debaene B, Odou P. Impact of physical incompatibility on drug mass flow rates: example of furosemide-midazolam incompatibility. Ann Intensive Care. 2012 Jul 13;2(1):28.

Semoun O, Marchand S, Gregoire N, Lamarche I, Adier C, Laroche L, Goldschmidt P, Couet W. Modeling approach to characterize intraocular doripenem pharmacokinetics after intravenous administration to rabbits, with tentative extrapolation to humans. Antimicrob Agents Chemother. 2012 Jul;56(7):3531–4.

Motamed C, Devys J-M, Debaene B, Billard V. Influence of real-time Bayesian forecasting of pharmacokinetic parameters on the precision of a rocuronium target-controlled infusion. Eur J Clin Pharmacol. 2012 Jul;68(7):1025–31.

Mimoz O, Petitpas F, Gregoire N, Gobin P, Marchand S, Couet W. Colistin distribution in the peritoneal fluid of a patient with severe peritonitis. Antimicrob Agents Chemother. 2012 Jul;56(7):4035–6.

Baginski L, Gobbo OL, Tewes F, Salomon JJ, Healy AM, Bakowsky U, Ehrhardt C. In vitro and in vivo characterisation of PEG-lipid-based micellar complexes of salmon calcitonin for pulmonary delivery. Pharm Res. 2012 Jun;29(6):1425–34.

Petitpas F, Kerforne T, Lacroix C, Mimoz O. Comment on ‘a novel approach to confirming nasogastric tube placement in the ED’. Am J Emerg Med. 2012 May;30(4):631–2.

Parienti J-J, du Cheyron D, Timsit J-F, Traore O, Kalfon P, Mimoz O, Mermel LA. Meta-analysis of subclavian insertion and nontunneled central venous catheter-associated infection risk reduction in critically ill adults. Crit Care Med. 2012 May;40(5):1627–34.

Mimoz O, Gregoire N, Poirel L, Marliat M, Couet W, Nordmann P. Broad-spectrum beta-lactam antibiotics for treating experimental peritonitis in mice due to Klebsiella pneumoniae producing the carbapenemase OXA-48. Antimicrob Agents Chemother. 2012 May;56(5):2759–60.

Godet C, Meurice J-C, Roblot F, Kauffmann-Lacroix C, Verdaguer M, Frat J-P, Cadranel J. Efficacy of nebulised liposomal amphotericin B in the attack and maintenance treatment of ABPA. Eur Respir J. 2012 May;39(5):1261–3.

Veinstein A, Debouverie O, Gregoire N, Goudet V, Adier C, Robert R, Couet W. Lack of effect of extracorporeal membrane oxygenation on tigecycline pharmacokinetics. J Antimicrob Chemother. 2012 Apr;67(4):1047–8.

Quenot J-P, Milesi C, Cravoisy A, Capellier G, Mimoz O, Fourcade O, Gueugniaud P-Y. Intrahospital transport of critically ill patients (excluding newborns) recommendations of the Societe de Reanimation de Langue Francaise (SRLF), the Societe Francaise d’Anesthesie et de Reanimation (SFAR), and the Societe Francaise de Medecine d’Urgence (SFMU). Ann Intensive Care. 2012 Feb 3;2(1):1.

Lannoy D, Decaudin B, Simon N, Barthelemy C, Debaene B, Odou P. The impact on drug mass flow rate of interrupting and resuming carrier fluid flow: an in vitro study on a very low dead-space volume infusion set. Anesth Analg. 2012 Feb;114(2):328–32.

Pichereau S, Pantrangi M, Couet W, Badiou C, Lina G, Shukla SK, Rose WE. Simulated antibiotic exposures in an in vitro hollow-fiber infection model influence toxin gene expression and production in community-associated methicillin-resistant Staphylococcus aureus strain MW2. Antimicrob Agents Chemother. 2012 Jan;56(1):140–7.

Kerforne T, Petitpas F, Frasca D, Goudet V, Robert R, Mimoz O. Ultrasound-guided peripheral venous access in severely ill patients with suspected difficult vascular puncture. Chest. 2012 Jan;141(1):279–80.

Baginski L, Tewes F, Buckley ST, Healy AM, Bakowsky U, Ehrhardt C. Investigations into the fate of inhaled salmon calcitonin at the respiratory epithelial barrier. Pharm Res. 2012 Jan;29(1):332–41.

Jacolot A, Judel C, Chaumais M-C, Louchahi K, Nicolas P, Marchand S, Petitjean O, Mimoz O. Animal model methodology: immunocompetent or leucopenic rats, which is the best? Results from a model of experimental pneumonia due to derepressed cephalosporinase-producing Enterobacter cloacae. Chemotherapy. 2012;58(2):129–33.


Spapen HD, Honore PM, Gregoire N, Gobin P, de Regt J, Martens GA, Pierard D, Couet W. Convulsions and apnoea in a patient infected with New Delhi metallo-beta-lactamase-1 Escherichia coli treated with colistin. J Infect. 2011 Dec;63(6):468–70.

Elsendoorn A, Agius G, Le Moal G, Aajaji F, Favier A-L, Wierzbicka-Hainault E, Beraud G, Flusin O, Crance J-M, Roblot F. Severe ear chondritis due to cowpox virus transmitted by a pet rat. J Infect. 2011 Nov;63(5):391–3.

Tewes F, Gobbo OL, Amaro MI, Tajber L, Corrigan OI, Ehrhardt C, Healy AM. Evaluation of HPbetaCD-PEG microparticles for salmon calcitonin administration via pulmonary delivery. Mol Pharm. 2011 Oct 3;8(5):1887–98.

Frasca D, Dahyot-Fizelier C, Catherine K, Levrat Q, Debaene B, Mimoz O. Accuracy of a continuous noninvasive hemoglobin monitor in intensive care unit patients. Crit Care Med. 2011 Oct;39(10):2277–82.

Tod M, Goutelle S, Clavel-Grabit F, Nicolas G, Charpiat B. Quantitative prediction of cytochrome P450 (CYP) 2D6-mediated drug interactions. Clin Pharmacokinet. 2011 Aug;50(8):519–30.

Tewes F, Krafft MP, Boury F. Dynamical and rheological properties of fluorinated surfactant films adsorbed at the pressurized CO2-H2O interface. Langmuir. 2011 Jul 5;27(13):8144–52.

Elsendoorn A, Robert R, Culos A, Roblot F, Burucoa C. Catabacter hongkongensis Bacteremia with fatal septic shock. Emerg Infect Dis. 2011 Jul;17(7):1330–1.

Renauld V, Goudet V, Mouton-Faivre C, Debaene B, Dewachter P. Case Report: perioperative immediate hypersensitivity involves not only allergy but also mastocytosis. Can J Anaesth. 2011 May;58(5):456–9.

Loupec T, Nanadoumgar H, Frasca D, Petitpas F, Laksiri L, Baudouin D, Debaene B, Dahyot-Fizelier C, Mimoz O. Pleth variability index predicts fluid responsiveness in critically ill patients. Crit Care Med. 2011 Feb;39(2):294–9.



Lannoy D, Decaudin B, Dewulf S, Simon N, Secq A, Barthelemy C, Debaene B, Odou P. Infusion set characteristics such as antireflux valve and dead-space volume affect drug delivery: an experimental study designed to enhance infusion sets. Anesth Analg. 2010 Dec;111(6):1427–31.

Mimoz O, Chauvet S, Gregoire N, Marchand S, Le Guern M-E, Saleh A, Couet W, Debaene B, Levy RH. Nefopam pharmacokinetics in patients with end-stage renal disease. Anesth Analg. 2010 Nov;111(5):1146–53.

Kalfon P, Mimoz O, Auquier P, Loundou A, Gauzit R, Lepape A, Laurens J, Garrigues B, Pottecher T, Malledant Y. Development and validation of a questionnaire for quantitative assessment of perceived discomforts in critically ill patients. Intensive Care Med. 2010 Oct;36(10):1751–8.

Marchand S, Gobin P, Brillault J, Baptista S, Adier C, Olivier J-C, Mimoz O, Couet W. Aerosol therapy with colistin methanesulfonate: a biopharmaceutical issue illustrated in rats. Antimicrob Agents Chemother. 2010 Sep;54(9):3702–7.

Marchand S, Lamarche I, Gobin P, Couet W. Dose-ranging pharmacokinetics of colistin methanesulphonate (CMS) and colistin in rats following single intravenous CMS doses. J Antimicrob Chemother. 2010 Aug;65(8):1753–8.

Marchand S, Frat J-P, Petitpas F, Lemaitre F, Gobin P, Robert R, Mimoz O, Couet W. Removal of colistin during intermittent haemodialysis in two critically ill patients. J Antimicrob Chemother. 2010 Aug;65(8):1836–7.

Dahyot-Fizelier C, Timofeev I, Marchand S, Hutchinson P, Debaene B, Menon D, Mimoz O, Gupta A, Couet W. Brain microdialysis study of meropenem in two patients with acute brain injury. Antimicrob Agents Chemother. 2010 Aug;54(8):3502–4.

Gregoire N, Raherison S, Grignon C, Comets E, Marliat M, Ploy M-C, Couet W. Semimechanistic pharmacokinetic-pharmacodynamic model with adaptation development for time-kill experiments of ciprofloxacin against Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2010 Jun;54(6):2379–84.

Gobin P, Lemaitre F, Marchand S, Couet W, Olivier J-C. Assay of colistin and colistin methanesulfonate in plasma and urine by liquid chromatography-tandem mass spectrometry. Antimicrob Agents Chemother. 2010 May;54(5):1941–8.

Dahyot-Fizelier C, Lefeuvre S, Laksiri L, Marchand S, Sawchuk RJ, Couet W, Mimoz O. Kinetics of imipenem distribution into the peritoneal fluid of patients with severe peritonitis studied by microdialysis. Clin Pharmacokinet. 2010 May;49(5):323–34.

Plaud B, Debaene B, Donati F, Marty J. Residual paralysis after emergence from anesthesia. Anesthesiology. 2010 Apr;112(4):1013–22.

Mimoz O. Preoperative skin cleansing with chlorhexidine-alcohol reduces surgical site infection after clean-contaminated surgery compared with povidone-iodine. Evid Based Nurs. 2010 Apr;13(2):36–7.

Frasca D, Marchand S, Petitpas F, Dahyot-Fizelier C, Couet W, Mimoz O. Pharmacokinetics of ertapenem following intravenous and subcutaneous infusions in patients. Antimicrob Agents Chemother. 2010 Feb;54(2):924–6.

Duvaldestin P, Kuizenga K, Saldien V, Claudius C, Servin F, Klein J, Debaene B, Heeringa M. A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia. Anesth Analg. 2010 Jan 1;110(1):74–82.

Brillault J, De Castro WV, Couet W. Relative contributions of active mediated transport and passive diffusion of fluoroquinolones with various lipophilicities in a Calu-3 lung epithelial cell model. Antimicrob Agents Chemother. 2010 Jan;54(1):543–5.

Frasca D, Dahyot-Fizelier C, Mimoz O. Prevention of central venous catheter-related infection in the intensive care unit. Crit Care. 2010;14(2):212.


Decaudin B, Dewulf S, Lannoy D, Simon N, Secq A, Barthelemy C, Debaene B, Odou P. Impact of multiaccess infusion devices on in vitro drug delivery during multi-infusion therapy. Anesth Analg. 2009 Oct;109(4):1147–55.

Brillault J, De Castro WV, Harnois T, Kitzis A, Olivier J-C, Couet W. P-glycoprotein-mediated transport of moxifloxacin in a Calu-3 lung epithelial cell model. Antimicrob Agents Chemother. 2009 Apr;53(4):1457–62.


Khalifa R, Dahyot-Fizelier C, Laksiri L, Ragot S, Petitpas F, Nanadoumgar H, Debaene B, Mimoz O. Indwelling time and risk of colonization of peripheral arterial catheters in critically ill patients. Intensive Care Med. 2008 Oct;34(10):1820–6.

Marchand S, Frasca D, Dahyot-Fizelier C, Breheret C, Mimoz O, Couet W. Lung microdialysis study of levofloxacin in rats following intravenous infusion at steady state. Antimicrob Agents Chemother. 2008 Sep;52(9):3074–7.

Leyre P, Desurmont T, Lacoste L, Odasso C, Bouche G, Beaulieu A, Valagier A, Charalambous C, Gibelin H, Debaene B, Kraimps J-L. Does the risk of compressive hematoma after thyroidectomy authorize 1-day surgery? Langenbecks Arch Surg. 2008 Sep;393(5):733–7.

Tewes F, Brillault J, Couet W, Olivier J-C. Formulation of rifampicin-cyclodextrin complexes for lung nebulization. J Control Release. 2008 Jul 14;129(2):93–9.

Tod M, Lagneau F, Jullien V, Mimoz O. A physiological model to evaluate drug kinetics in patients with hemorrhagic shock followed by fluid resuscitation. Application to amoxicillin-clavulanate. Pharm Res. 2008 Jun;25(6):1431–9.

Lefeuvre S, Marchand S, Pariat C, Lamarche I, Couet W. Microdialysis study of imipenem distribution in the peritoneal fluid of rats with experimental acute pancreatitis. Antimicrob Agents Chemother. 2008 Apr;52(4):1516–8.

Venisse N, Gregoire N, Marliat M, Couet W. Mechanism-based pharmacokinetic-pharmacodynamic models of in vitro fungistatic and fungicidal effects against Candida albicans. Antimicrob Agents Chemother. 2008 Mar;52(3):937–43.

Lefeuvre S, Venisse N, Marchand S, Bachelet M, Couet W. A simple and sensitive liquid chromatography-tandem mass spectrometry assay for the quantification of ertapenem in microdialysate. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 1;862(1–2):242–5.

Brillault J, Lam TI, Rutkowsky JM, Foroutan S, O’Donnell ME. Hypoxia effects on cell volume and ion uptake of cerebral microvascular endothelial cells. Am J Physiol Cell Physiol. 2008 Jan;294(1):C88-96.

Dahyot C, Marchand S, Bodin M, Debeane B, Mimoz O, Couet W. Application of basic pharmacokinetic concepts to analysis of microdialysis data: illustration with imipenem muscle distribution. Clin Pharmacokinet. 2008;47(3):181–9.


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